Norovirus: Facts and Reflections from Past, Present, and Future
Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and dis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/12/2399 |
| _version_ | 1797499949971144704 |
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| author | Yalda Lucero David O. Matson Shai Ashkenazi Sergio George Miguel O’Ryan |
| author_facet | Yalda Lucero David O. Matson Shai Ashkenazi Sergio George Miguel O’Ryan |
| author_sort | Yalda Lucero |
| collection | DOAJ |
| description | Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral–host–microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease. |
| first_indexed | 2024-03-10T03:54:49Z |
| format | Article |
| id | doaj.art-1700638a911945c9915fb8d37c0eb3f3 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T03:54:49Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1700638a911945c9915fb8d37c0eb3f32023-11-23T10:57:22ZengMDPI AGViruses1999-49152021-11-011312239910.3390/v13122399Norovirus: Facts and Reflections from Past, Present, and FutureYalda Lucero0David O. Matson1Shai Ashkenazi2Sergio George3Miguel O’Ryan4Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileEastern Shore Health Department, Virginia Department of Public Health, Accomack County, VA 23301, USAAdelson School of Medicine, Ariel University, Ariel 40700, IsraelMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileHuman Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral–host–microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease.https://www.mdpi.com/1999-4915/13/12/2399Norovirusepidemiologypreventionvaccine |
| spellingShingle | Yalda Lucero David O. Matson Shai Ashkenazi Sergio George Miguel O’Ryan Norovirus: Facts and Reflections from Past, Present, and Future Viruses Norovirus epidemiology prevention vaccine |
| title | Norovirus: Facts and Reflections from Past, Present, and Future |
| title_full | Norovirus: Facts and Reflections from Past, Present, and Future |
| title_fullStr | Norovirus: Facts and Reflections from Past, Present, and Future |
| title_full_unstemmed | Norovirus: Facts and Reflections from Past, Present, and Future |
| title_short | Norovirus: Facts and Reflections from Past, Present, and Future |
| title_sort | norovirus facts and reflections from past present and future |
| topic | Norovirus epidemiology prevention vaccine |
| url | https://www.mdpi.com/1999-4915/13/12/2399 |
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