Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes
Since early times, being overweight and obesity have been associated with impaired glucose metabolism and type 2 diabetes (T2D). Similarly, a less frequent adult-onset diabetes in low body mass index (BMI) people has been known for many decades. This form is mainly found in developing countries, whe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/658 |
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| author | Teresa Salvatore Raffaele Galiero Alfredo Caturano Luca Rinaldi Livio Criscuolo Anna Di Martino Gaetana Albanese Erica Vetrano Christian Catalini Celestino Sardu Giovanni Docimo Raffaele Marfella Ferdinando Carlo Sasso |
| author_facet | Teresa Salvatore Raffaele Galiero Alfredo Caturano Luca Rinaldi Livio Criscuolo Anna Di Martino Gaetana Albanese Erica Vetrano Christian Catalini Celestino Sardu Giovanni Docimo Raffaele Marfella Ferdinando Carlo Sasso |
| author_sort | Teresa Salvatore |
| collection | DOAJ |
| description | Since early times, being overweight and obesity have been associated with impaired glucose metabolism and type 2 diabetes (T2D). Similarly, a less frequent adult-onset diabetes in low body mass index (BMI) people has been known for many decades. This form is mainly found in developing countries, whereby the largest increase in diabetes incidence is expected in coming years. The number of non-obese patients with T2D is also on the rise among non-white ethnic minorities living in high-income Western countries due to growing migratory flows. A great deal of energy has been spent on understanding the mechanisms that bind obesity to T2D. Conversely, the pathophysiologic features and factors driving the risk of T2D development in non-obese people are still much debated. To reduce the global burden of diabetes, we need to understand why not all obese people develop T2D and not all those with T2D are obese. Moreover, through both an effective prevention and the implementation of an individualized clinical management in all people with diabetes, it is hoped that this will help to reduce this global burden. The purpose of this review is to take stock of current knowledge about the pathophysiology of diabetes not associated to obesity and to highlight which aspects are worthy of future studies. |
| first_indexed | 2024-03-11T09:58:34Z |
| format | Article |
| id | doaj.art-170187d7fb3a43e88534c5dcb26bdc17 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:58:34Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-170187d7fb3a43e88534c5dcb26bdc172023-11-16T15:36:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124165810.3390/ijms24010658Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 DiabetesTeresa Salvatore0Raffaele Galiero1Alfredo Caturano2Luca Rinaldi3Livio Criscuolo4Anna Di Martino5Gaetana Albanese6Erica Vetrano7Christian Catalini8Celestino Sardu9Giovanni Docimo10Raffaele Marfella11Ferdinando Carlo Sasso12Department of Precision Medicine, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I–80138 Naples, ItalySince early times, being overweight and obesity have been associated with impaired glucose metabolism and type 2 diabetes (T2D). Similarly, a less frequent adult-onset diabetes in low body mass index (BMI) people has been known for many decades. This form is mainly found in developing countries, whereby the largest increase in diabetes incidence is expected in coming years. The number of non-obese patients with T2D is also on the rise among non-white ethnic minorities living in high-income Western countries due to growing migratory flows. A great deal of energy has been spent on understanding the mechanisms that bind obesity to T2D. Conversely, the pathophysiologic features and factors driving the risk of T2D development in non-obese people are still much debated. To reduce the global burden of diabetes, we need to understand why not all obese people develop T2D and not all those with T2D are obese. Moreover, through both an effective prevention and the implementation of an individualized clinical management in all people with diabetes, it is hoped that this will help to reduce this global burden. The purpose of this review is to take stock of current knowledge about the pathophysiology of diabetes not associated to obesity and to highlight which aspects are worthy of future studies.https://www.mdpi.com/1422-0067/24/1/658type 2 diabetes mellitusnormal-weightpathophysiology |
| spellingShingle | Teresa Salvatore Raffaele Galiero Alfredo Caturano Luca Rinaldi Livio Criscuolo Anna Di Martino Gaetana Albanese Erica Vetrano Christian Catalini Celestino Sardu Giovanni Docimo Raffaele Marfella Ferdinando Carlo Sasso Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes International Journal of Molecular Sciences type 2 diabetes mellitus normal-weight pathophysiology |
| title | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
| title_full | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
| title_fullStr | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
| title_full_unstemmed | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
| title_short | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
| title_sort | current knowledge on the pathophysiology of lean normal weight type 2 diabetes |
| topic | type 2 diabetes mellitus normal-weight pathophysiology |
| url | https://www.mdpi.com/1422-0067/24/1/658 |
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