Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1
ABSTRACTThe highly mutated BA.2.86, with over 30 spike protein mutations in comparison to Omicron BA.2 and XBB.1.5 variants, has raised concerns about its potential to evade COVID-19 vaccination or prior SARS-CoV-2 infection-elicited immunity. In this study, we employ a live SARS-CoV-2 neutralizatio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2271089 |
| _version_ | 1797257033883320320 |
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| author | Yanping Hu Jing Zou Chaitanya Kurhade Xiangxue Deng Hope C. Chang Debora K. Kim Pei-Yong Shi Ping Ren Xuping Xie |
| author_facet | Yanping Hu Jing Zou Chaitanya Kurhade Xiangxue Deng Hope C. Chang Debora K. Kim Pei-Yong Shi Ping Ren Xuping Xie |
| author_sort | Yanping Hu |
| collection | DOAJ |
| description | ABSTRACTThe highly mutated BA.2.86, with over 30 spike protein mutations in comparison to Omicron BA.2 and XBB.1.5 variants, has raised concerns about its potential to evade COVID-19 vaccination or prior SARS-CoV-2 infection-elicited immunity. In this study, we employ a live SARS-CoV-2 neutralization assay to compare the neutralization evasion ability of BA.2.86 with other emerged SARS-CoV-2 subvariants, including BA.2-derived CH.1.1, Delta-Omicron recombinant XBC.1.6, and XBB descendants XBB.1.5, XBB.1.16, XBB.2.3, EG.5.1 and FL.1.5.1. Our results show that BA.2.86 is less neutralization evasive than XBB sublineages. XBB descendants XBB.1.16, EG.5.1, and FL.1.5.1 continue to significantly evade neutralization induced by the parental COVID-19 mRNA vaccine and a BA.5 Bivalent booster. Notably, when compared to XBB.1.5, the more recent XBB descendants, particularly EG.5.1, display increased resistance to neutralization. Among all the tested variants, CH.1.1 exhibits the greatest neutralization evasion. In contrast, XBC.1.6 shows a slight reduction but remains comparably sensitive to neutralization when compared to BA.5. Furthermore, a recent XBB.1.5-breakthrough infection significantly enhances the breadth and potency of cross-neutralization. These findings reinforce the expectation that the upcoming XBB.1.5 mRNA vaccine would likely boost the neutralization of currently circulating variants, while also underscoring the critical importance of ongoing surveillance to monitor the evolution and immune evasion potential of SARS-CoV-2 variants. |
| first_indexed | 2024-03-08T11:52:03Z |
| format | Article |
| id | doaj.art-1701d36387e84cb1888a7ae518cbfd78 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-24T22:31:13Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-1701d36387e84cb1888a7ae518cbfd782024-03-19T19:34:17ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2271089Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1Yanping Hu0Jing Zou1Chaitanya Kurhade2Xiangxue Deng3Hope C. Chang4Debora K. Kim5Pei-Yong Shi6Ping Ren7Xuping Xie8Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USADepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USADepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USADepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USADepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USAABSTRACTThe highly mutated BA.2.86, with over 30 spike protein mutations in comparison to Omicron BA.2 and XBB.1.5 variants, has raised concerns about its potential to evade COVID-19 vaccination or prior SARS-CoV-2 infection-elicited immunity. In this study, we employ a live SARS-CoV-2 neutralization assay to compare the neutralization evasion ability of BA.2.86 with other emerged SARS-CoV-2 subvariants, including BA.2-derived CH.1.1, Delta-Omicron recombinant XBC.1.6, and XBB descendants XBB.1.5, XBB.1.16, XBB.2.3, EG.5.1 and FL.1.5.1. Our results show that BA.2.86 is less neutralization evasive than XBB sublineages. XBB descendants XBB.1.16, EG.5.1, and FL.1.5.1 continue to significantly evade neutralization induced by the parental COVID-19 mRNA vaccine and a BA.5 Bivalent booster. Notably, when compared to XBB.1.5, the more recent XBB descendants, particularly EG.5.1, display increased resistance to neutralization. Among all the tested variants, CH.1.1 exhibits the greatest neutralization evasion. In contrast, XBC.1.6 shows a slight reduction but remains comparably sensitive to neutralization when compared to BA.5. Furthermore, a recent XBB.1.5-breakthrough infection significantly enhances the breadth and potency of cross-neutralization. These findings reinforce the expectation that the upcoming XBB.1.5 mRNA vaccine would likely boost the neutralization of currently circulating variants, while also underscoring the critical importance of ongoing surveillance to monitor the evolution and immune evasion potential of SARS-CoV-2 variants.https://www.tandfonline.com/doi/10.1080/22221751.2023.2271089SARS-CoV-2neutralizationvariantsBA.2.86mRNA vaccine |
| spellingShingle | Yanping Hu Jing Zou Chaitanya Kurhade Xiangxue Deng Hope C. Chang Debora K. Kim Pei-Yong Shi Ping Ren Xuping Xie Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1 Emerging Microbes and Infections SARS-CoV-2 neutralization variants BA.2.86 mRNA vaccine |
| title | Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1 |
| title_full | Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1 |
| title_fullStr | Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1 |
| title_full_unstemmed | Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1 |
| title_short | Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1 |
| title_sort | less neutralization evasion of sars cov 2 ba 2 86 than xbb sublineages and ch 1 1 |
| topic | SARS-CoV-2 neutralization variants BA.2.86 mRNA vaccine |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2271089 |
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