Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8

Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8

Patients treated with paclitaxel (PTX) or other antineoplastic agents can experience chemotherapy-induced peripheral neuropathy (CIPN), a debilitating side effect characterized by numbness and pain. PTX interferes with microtubule-based transport, which inhibits tumor growth via cell cycle arrest bu...

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Bibliographic Details
Main Authors: Christopher A. Baker, Sidharth Tyagi, Grant P. Higerd-Rusli, Shujun Liu, Peng Zhao, Fadia B. Dib-Hajj, Stephen G. Waxman, Sulayman D. Dib-Hajj
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
paclitaxel
chemotherapy
neuropathy
pain
sodium channels
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1130123/full

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