Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity
Although treatment outcomes of glioblastoma, the most malignant central nervous system (CNS) tumor, has improved in the past decades, it is still incurable, and survival has only slightly improved. Advances in molecular biology and genetics have completely transformed our understanding of glioblasto...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/18/10005 |
| _version_ | 1797518870376873984 |
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| author | Gábor Hutóczki József Virga Zsuzsanna Birkó Almos Klekner |
| author_facet | Gábor Hutóczki József Virga Zsuzsanna Birkó Almos Klekner |
| author_sort | Gábor Hutóczki |
| collection | DOAJ |
| description | Although treatment outcomes of glioblastoma, the most malignant central nervous system (CNS) tumor, has improved in the past decades, it is still incurable, and survival has only slightly improved. Advances in molecular biology and genetics have completely transformed our understanding of glioblastoma. Multiple classifications and different diagnostic methods were made according to novel molecular markers. Discovering tumor heterogeneity only partially explains the ineffectiveness of current anti-proliferative therapies. Dynamic heterogeneity secures resistance to combined oncotherapy. As tumor growth proceeds, new therapy-resistant sub clones emerge. Liquid biopsy is a new and promising diagnostic tool that can step up with the dynamic genetic change. Getting a ’real-time’ picture of a specific tumor, anti-invasion and multi-target treatment can be designed. During invasion to the peri-tumoral brain tissue, glioma cells interact with the extracellular matrix components. The expressional levels of these matrix molecules give a characteristic pattern, the invasion spectrum, which possess vast diagnostical, predictive and prognostic information. It is a huge leap forward combating tumor heterogeneity and searching for novel therapies. Using the invasion spectrum of a tumor sample is a novel tool to distinguish between histological subtypes, specifying the tumor grades or different prognostic groups. Moreover, new therapeutic methods and their combinations are under trial. These are crucial steps towards personalized oncotherapy. |
| first_indexed | 2024-03-10T07:35:27Z |
| format | Article |
| id | doaj.art-1704f90ce62c4495bcd1f0a8f1abe306 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:35:27Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1704f90ce62c4495bcd1f0a8f1abe3062023-11-22T13:31:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122181000510.3390/ijms221810005Novel Concepts of Glioblastoma Therapy Concerning Its HeterogeneityGábor Hutóczki0József Virga1Zsuzsanna Birkó2Almos Klekner3Department of Neurosurgery, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Oncology, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Human Genetics, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Neurosurgery, University of Debrecen, H-4032 Debrecen, HungaryAlthough treatment outcomes of glioblastoma, the most malignant central nervous system (CNS) tumor, has improved in the past decades, it is still incurable, and survival has only slightly improved. Advances in molecular biology and genetics have completely transformed our understanding of glioblastoma. Multiple classifications and different diagnostic methods were made according to novel molecular markers. Discovering tumor heterogeneity only partially explains the ineffectiveness of current anti-proliferative therapies. Dynamic heterogeneity secures resistance to combined oncotherapy. As tumor growth proceeds, new therapy-resistant sub clones emerge. Liquid biopsy is a new and promising diagnostic tool that can step up with the dynamic genetic change. Getting a ’real-time’ picture of a specific tumor, anti-invasion and multi-target treatment can be designed. During invasion to the peri-tumoral brain tissue, glioma cells interact with the extracellular matrix components. The expressional levels of these matrix molecules give a characteristic pattern, the invasion spectrum, which possess vast diagnostical, predictive and prognostic information. It is a huge leap forward combating tumor heterogeneity and searching for novel therapies. Using the invasion spectrum of a tumor sample is a novel tool to distinguish between histological subtypes, specifying the tumor grades or different prognostic groups. Moreover, new therapeutic methods and their combinations are under trial. These are crucial steps towards personalized oncotherapy.https://www.mdpi.com/1422-0067/22/18/10005glioblastomaliquid biopsyinvasion spectrumoncotherapy |
| spellingShingle | Gábor Hutóczki József Virga Zsuzsanna Birkó Almos Klekner Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity International Journal of Molecular Sciences glioblastoma liquid biopsy invasion spectrum oncotherapy |
| title | Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity |
| title_full | Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity |
| title_fullStr | Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity |
| title_full_unstemmed | Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity |
| title_short | Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity |
| title_sort | novel concepts of glioblastoma therapy concerning its heterogeneity |
| topic | glioblastoma liquid biopsy invasion spectrum oncotherapy |
| url | https://www.mdpi.com/1422-0067/22/18/10005 |
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