Role of Cytology in Pleural Effusion: A Single-Center Experience
Objective: As a fast and effective method, cytopathological examination of the pleural fluid is the diagnostic tool of choice in determining the etiology of a spectrum of inflammatory to neoplastic conditions. The aim of the present study was to investigate the role of pleural cytology samples exami...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2019-11-01
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| Series: | Erciyes Medical Journal |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-88557 |
| _version_ | 1797912341949448192 |
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| author | Canan Sadullahoğlu Ruşen Uzun |
| author_facet | Canan Sadullahoğlu Ruşen Uzun |
| author_sort | Canan Sadullahoğlu |
| collection | DOAJ |
| description | Objective: As a fast and effective method, cytopathological examination of the pleural fluid is the diagnostic tool of choice in determining the etiology of a spectrum of inflammatory to neoplastic conditions. The aim of the present study was to investigate the role of pleural cytology samples examined within a certain time period in determining the presence of malignant cells.
Materials and Methods: Cytological materials of 433 patients with pleural effusion (PE) were retrospectively analyzed. Clinical parameters and cytological diagnosis were recorded in consecutive patients with PE.
Results: Of the 433 cases enrolled in the study, 264 (61%) were male, and 169 (39%) were female. 15.6% (67/433) of the cases were reported as malignant, and 85% were aged >50 years. It was found that the contribution of repeated cytological examination of a material to diagnosis was approximately 3%. The sensitivity and specificity of the cytological method were calculated as 34% and 99%, respectively. Immunocytochemistry was performed in 50 patients who received cell-block techniques, and 42.4% of those were diagnosed as malignant. Molecular tests were also performed in 5 patients.
Conclusion: Although the sensitivity is low, cytological examination of the pleura can be considered a diagnostic tool of vital importance, especially in patients with an advanced-stage disease and poor performance, who can benefit from rapidly evolving and changing treatment options. |
| first_indexed | 2024-04-10T11:54:29Z |
| format | Article |
| id | doaj.art-170527bb076c488a96c11e993b1af3dc |
| institution | Directory Open Access Journal |
| issn | 2149-2247 |
| language | English |
| last_indexed | 2024-04-10T11:54:29Z |
| publishDate | 2019-11-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Erciyes Medical Journal |
| spelling | doaj.art-170527bb076c488a96c11e993b1af3dc2023-02-15T16:16:51ZengKARE PublishingErciyes Medical Journal2149-22472019-11-0141440941310.14744/etd.2019.88557EMJ-88557Role of Cytology in Pleural Effusion: A Single-Center ExperienceCanan Sadullahoğlu0Ruşen Uzun1Department of Pathology, Health Sciences University, Antalya Training and Research Hospital, Antalya, TurkeyDepartment of Pulmonology, Health Sciences University, Antalya Training and Research Hospital, Antalya, TurkeyObjective: As a fast and effective method, cytopathological examination of the pleural fluid is the diagnostic tool of choice in determining the etiology of a spectrum of inflammatory to neoplastic conditions. The aim of the present study was to investigate the role of pleural cytology samples examined within a certain time period in determining the presence of malignant cells. Materials and Methods: Cytological materials of 433 patients with pleural effusion (PE) were retrospectively analyzed. Clinical parameters and cytological diagnosis were recorded in consecutive patients with PE. Results: Of the 433 cases enrolled in the study, 264 (61%) were male, and 169 (39%) were female. 15.6% (67/433) of the cases were reported as malignant, and 85% were aged >50 years. It was found that the contribution of repeated cytological examination of a material to diagnosis was approximately 3%. The sensitivity and specificity of the cytological method were calculated as 34% and 99%, respectively. Immunocytochemistry was performed in 50 patients who received cell-block techniques, and 42.4% of those were diagnosed as malignant. Molecular tests were also performed in 5 patients. Conclusion: Although the sensitivity is low, cytological examination of the pleura can be considered a diagnostic tool of vital importance, especially in patients with an advanced-stage disease and poor performance, who can benefit from rapidly evolving and changing treatment options.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-88557immunocytochemistrymolecular targeted therapymalignant pleural effusion. |
| spellingShingle | Canan Sadullahoğlu Ruşen Uzun Role of Cytology in Pleural Effusion: A Single-Center Experience Erciyes Medical Journal immunocytochemistry molecular targeted therapy malignant pleural effusion. |
| title | Role of Cytology in Pleural Effusion: A Single-Center Experience |
| title_full | Role of Cytology in Pleural Effusion: A Single-Center Experience |
| title_fullStr | Role of Cytology in Pleural Effusion: A Single-Center Experience |
| title_full_unstemmed | Role of Cytology in Pleural Effusion: A Single-Center Experience |
| title_short | Role of Cytology in Pleural Effusion: A Single-Center Experience |
| title_sort | role of cytology in pleural effusion a single center experience |
| topic | immunocytochemistry molecular targeted therapy malignant pleural effusion. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-88557 |
| work_keys_str_mv | AT canansadullahoglu roleofcytologyinpleuraleffusionasinglecenterexperience AT rusenuzun roleofcytologyinpleuraleffusionasinglecenterexperience |