Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug Response

Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug Response

Glioblastoma (GBM) is a lethal, incurable form of cancer in the brain. Even with maximally aggressive surgery and chemoradiotherapy, median patient survival is 14.5 months. These tumors infiltrate normal brain tissue, are surgically incurable, and universally recur. GBMs are characterized by genetic...

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Bibliographic Details
Main Authors: Hemamylammal Sivakumar, Mahesh Devarasetty, David E. Kram, Roy E. Strowd, Aleksander Skardal
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
glioblastoma
spheroid
organoid
drug response
tumor heterogeneity
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.538663/full

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