Inflammatory markers and physical frailty: towards clinical application
Abstract Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and is considered an important indicator of adverse events in the older population. Therefore, there is growing interest in the early diagnosis and in...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Immunity & Ageing |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12979-023-00410-3 |
| _version_ | 1827388115505905664 |
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| author | Yiming Pan Lina Ma |
| author_facet | Yiming Pan Lina Ma |
| author_sort | Yiming Pan |
| collection | DOAJ |
| description | Abstract Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and is considered an important indicator of adverse events in the older population. Therefore, there is growing interest in the early diagnosis and intervention of frailty, but the cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation is related to decreased physical function and increased disease risk. Additionally, multiple human and animal studies suggest that inflammation probably plays the largest role in contributing to frailty. Some inflammatory markers have been proposed to predict physical frailty. However, there are still large gaps in knowledge related to the clinical application of these markers in frail patients. Therefore, understanding the biological processes and identifying recognized and reliable markers are urgent and pivotal tasks for geriatricians. In the present review, we broadly summarize the inflammatory markers that may have potential diagnostic and therapeutic use, thereby translating them into health care for older people with frailty in the near future. |
| first_indexed | 2024-03-08T16:13:00Z |
| format | Article |
| id | doaj.art-1707ef88fa124297a83da08ea9ee2473 |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-03-08T16:13:00Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-1707ef88fa124297a83da08ea9ee24732024-01-07T12:47:04ZengBMCImmunity & Ageing1742-49332024-01-012111810.1186/s12979-023-00410-3Inflammatory markers and physical frailty: towards clinical applicationYiming Pan0Lina Ma1Department of Geriatrics, Xuanwu Hospital Capital Medical University, National Research Center for Geriatric MedicineDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Research Center for Geriatric MedicineAbstract Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and is considered an important indicator of adverse events in the older population. Therefore, there is growing interest in the early diagnosis and intervention of frailty, but the cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation is related to decreased physical function and increased disease risk. Additionally, multiple human and animal studies suggest that inflammation probably plays the largest role in contributing to frailty. Some inflammatory markers have been proposed to predict physical frailty. However, there are still large gaps in knowledge related to the clinical application of these markers in frail patients. Therefore, understanding the biological processes and identifying recognized and reliable markers are urgent and pivotal tasks for geriatricians. In the present review, we broadly summarize the inflammatory markers that may have potential diagnostic and therapeutic use, thereby translating them into health care for older people with frailty in the near future.https://doi.org/10.1186/s12979-023-00410-3Physical frailtyInflammationMarkerBiologicalAging |
| spellingShingle | Yiming Pan Lina Ma Inflammatory markers and physical frailty: towards clinical application Immunity & Ageing Physical frailty Inflammation Marker Biological Aging |
| title | Inflammatory markers and physical frailty: towards clinical application |
| title_full | Inflammatory markers and physical frailty: towards clinical application |
| title_fullStr | Inflammatory markers and physical frailty: towards clinical application |
| title_full_unstemmed | Inflammatory markers and physical frailty: towards clinical application |
| title_short | Inflammatory markers and physical frailty: towards clinical application |
| title_sort | inflammatory markers and physical frailty towards clinical application |
| topic | Physical frailty Inflammation Marker Biological Aging |
| url | https://doi.org/10.1186/s12979-023-00410-3 |
| work_keys_str_mv | AT yimingpan inflammatorymarkersandphysicalfrailtytowardsclinicalapplication AT linama inflammatorymarkersandphysicalfrailtytowardsclinicalapplication |