Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines
Herbal drugs or herbal medicines (HMs) have a long-standing history as natural remedies for preventing and curing diseases. HMs have garnered greater interest during the past decades due to their broad, synergistic actions on the physiological systems and relatively lower incidence of adverse events...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.853023/full |
| _version_ | 1818264579080192000 |
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| author | Eka Noviana Gunawan Indrayanto Abdul Rohman Abdul Rohman |
| author_facet | Eka Noviana Gunawan Indrayanto Abdul Rohman Abdul Rohman |
| author_sort | Eka Noviana |
| collection | DOAJ |
| description | Herbal drugs or herbal medicines (HMs) have a long-standing history as natural remedies for preventing and curing diseases. HMs have garnered greater interest during the past decades due to their broad, synergistic actions on the physiological systems and relatively lower incidence of adverse events, compared to synthetic drugs. However, assuring reproducible quality, efficacy, and safety from herbal drugs remains a challenging task. HMs typically consist of many constituents whose presence and quantity may vary among different sources of materials. Fingerprint analysis has emerged as a very useful technique to assess the quality of herbal drug materials and formulations for establishing standardized herbal products. Rather than using a single or two marker(s), fingerprinting techniques take great consideration of the complexity of herbal drugs by evaluating the whole chemical profile and extracting a common pattern to be set as a criterion for assessing the individual material or formulation. In this review, we described and assessed various fingerprinting techniques reported to date, which are applicable to the standardization and quality control of HMs. We also evaluated the application of multivariate data analysis or chemometrics in assisting the analysis of the complex datasets from the determination of HMs. To ensure that these methods yield reliable results, we reviewed the validation status of the methods and provided perspectives on those. Finally, we concluded by highlighting major accomplishments and presenting a gap analysis between the existing techniques and what is needed to continue moving forward. |
| first_indexed | 2024-12-12T19:37:09Z |
| format | Article |
| id | doaj.art-17081dda0561428e801ca0dac04fa0a0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T19:37:09Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-17081dda0561428e801ca0dac04fa0a02022-12-22T00:14:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-06-011310.3389/fphar.2022.853023853023Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal MedicinesEka Noviana0Gunawan Indrayanto1Abdul Rohman2Abdul Rohman3Departement of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, IndonesiaFaculty of Pharmacy, Universitas Surabaya, Surabaya, IndonesiaDepartement of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, IndonesiaCenter of Excellence, Institute for Halal Industry and Systems, Universitas Gadjah Mada, Yogyakarta, IndonesiaHerbal drugs or herbal medicines (HMs) have a long-standing history as natural remedies for preventing and curing diseases. HMs have garnered greater interest during the past decades due to their broad, synergistic actions on the physiological systems and relatively lower incidence of adverse events, compared to synthetic drugs. However, assuring reproducible quality, efficacy, and safety from herbal drugs remains a challenging task. HMs typically consist of many constituents whose presence and quantity may vary among different sources of materials. Fingerprint analysis has emerged as a very useful technique to assess the quality of herbal drug materials and formulations for establishing standardized herbal products. Rather than using a single or two marker(s), fingerprinting techniques take great consideration of the complexity of herbal drugs by evaluating the whole chemical profile and extracting a common pattern to be set as a criterion for assessing the individual material or formulation. In this review, we described and assessed various fingerprinting techniques reported to date, which are applicable to the standardization and quality control of HMs. We also evaluated the application of multivariate data analysis or chemometrics in assisting the analysis of the complex datasets from the determination of HMs. To ensure that these methods yield reliable results, we reviewed the validation status of the methods and provided perspectives on those. Finally, we concluded by highlighting major accomplishments and presenting a gap analysis between the existing techniques and what is needed to continue moving forward.https://www.frontiersin.org/articles/10.3389/fphar.2022.853023/fullherbal medicinesfingerprint analysischemometricschemical fingerprintDNA fingerprint |
| spellingShingle | Eka Noviana Gunawan Indrayanto Abdul Rohman Abdul Rohman Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines Frontiers in Pharmacology herbal medicines fingerprint analysis chemometrics chemical fingerprint DNA fingerprint |
| title | Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines |
| title_full | Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines |
| title_fullStr | Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines |
| title_full_unstemmed | Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines |
| title_short | Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines |
| title_sort | advances in fingerprint analysis for standardization and quality control of herbal medicines |
| topic | herbal medicines fingerprint analysis chemometrics chemical fingerprint DNA fingerprint |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.853023/full |
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