Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes

Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes

Abstract Background In vitro and in vivo studies have shown that certain cytokines and hormones may play a role in the development and progression of type 2 diabetes (T2D). However, studies on their role in T2D in humans are scarce. We evaluated associations between 11 circulating cytokines and horm...

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Bibliographic Details
Main Authors: Karlijn A. C. Meeks, Amy R. Bentley, Themistocles L. Assimes, Nora Franceschini, Adebowale A. Adeyemo, Charles N. Rotimi, Ayo P. Doumatey
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Genome Medicine
Subjects:
Cytokines
Hormones
Type 2 diabetes
Sub-Saharan Africans
Mendelian randomization
Causal inference
Online Access:https://doi.org/10.1186/s13073-023-01263-7

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