Development and Evaluation of Ondansetron Orally Disintegrating Tablets
Orally disintegrating tablet (ODT) has number of advantages like faster onset of action, ease of administration, rapid disintegration and dissolution etc. A novel attempt has been made to develop orally disintegrating tablets of Ondansetron by using two approaches, one is soluble hydrophilic matrix...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2019-12-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/548/ |
| _version_ | 1797821743817031680 |
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| author | Bipin Pustake Vikram Gharge Ratnakar Korhale Anil Gadhe |
| author_facet | Bipin Pustake Vikram Gharge Ratnakar Korhale Anil Gadhe |
| author_sort | Bipin Pustake |
| collection | DOAJ |
| description | Orally disintegrating tablet (ODT) has number of advantages like faster onset of action, ease of administration, rapid disintegration and dissolution etc. A novel attempt has been made to develop orally disintegrating tablets of Ondansetron by using two approaches, one is soluble hydrophilic matrix by superdisintegrant and other is effect of sweetener on the formulation. Direct compression method was employed for making orally disintegrating tablets. The formulated orally disintegrating tablets have rapid disintegration property for better patient compliance. Formulated tablets were evaluated for physical parameters along with wetting time, disintegration time, drug content and “in vitro” dissolution. In first approach it was found that batch F7 containing Crospovidone (Polyplasdone XL 10) 10 mg showed minimum disintegration time (i.e. approx. 7.00 seconds) with maximum drug release. Wetting time for batch F7 was found to be minimum (i.e. 12 seconds). In second approach of selection of sweetener batch F 10 containing Sodium saccharin was found better in terms of Impurity study (Relative Substances study).Impurity was found within the specified limit compared to other two sweeteners. Stability study was carried out on optimized formulation. Overall batch containing 10 mg Crospovidone (Polyplasdone XL 10) along with Sodium Saccharin was found stable both physically and chemically. |
| first_indexed | 2024-03-13T09:57:16Z |
| format | Article |
| id | doaj.art-1708e536e7b34778af9b5cbcd1a821ab |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T09:57:16Z |
| publishDate | 2019-12-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-1708e536e7b34778af9b5cbcd1a821ab2023-05-23T14:01:45ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562019-12-013110.5920/bjpharm.2018.06Development and Evaluation of Ondansetron Orally Disintegrating TabletsBipin Pustake0Vikram Gharge1https://orcid.org/0000-0003-4456-6463Ratnakar Korhale2https://orcid.org/0000-0001-8267-1614Anil Gadhe3https://orcid.org/0000-0003-0849-1281Formulation R&D ZUVENTUS HEALTHCARE LTD.Formulation R&D ZUVENTUS HEALTHCARE LTD.Formulation R&D ZUVENTUS HEALTHCARE LTD.Formulation R&D ZUVENTUS HEALTHCARE LTD.Orally disintegrating tablet (ODT) has number of advantages like faster onset of action, ease of administration, rapid disintegration and dissolution etc. A novel attempt has been made to develop orally disintegrating tablets of Ondansetron by using two approaches, one is soluble hydrophilic matrix by superdisintegrant and other is effect of sweetener on the formulation. Direct compression method was employed for making orally disintegrating tablets. The formulated orally disintegrating tablets have rapid disintegration property for better patient compliance. Formulated tablets were evaluated for physical parameters along with wetting time, disintegration time, drug content and “in vitro” dissolution. In first approach it was found that batch F7 containing Crospovidone (Polyplasdone XL 10) 10 mg showed minimum disintegration time (i.e. approx. 7.00 seconds) with maximum drug release. Wetting time for batch F7 was found to be minimum (i.e. 12 seconds). In second approach of selection of sweetener batch F 10 containing Sodium saccharin was found better in terms of Impurity study (Relative Substances study).Impurity was found within the specified limit compared to other two sweeteners. Stability study was carried out on optimized formulation. Overall batch containing 10 mg Crospovidone (Polyplasdone XL 10) along with Sodium Saccharin was found stable both physically and chemically.https://www.bjpharm.org.uk/article/id/548/orally disintegrating tabletssweetenerssuperdisintegrantsondansetron |
| spellingShingle | Bipin Pustake Vikram Gharge Ratnakar Korhale Anil Gadhe Development and Evaluation of Ondansetron Orally Disintegrating Tablets British Journal of Pharmacy orally disintegrating tablets sweeteners superdisintegrants ondansetron |
| title | Development and Evaluation of Ondansetron Orally Disintegrating Tablets |
| title_full | Development and Evaluation of Ondansetron Orally Disintegrating Tablets |
| title_fullStr | Development and Evaluation of Ondansetron Orally Disintegrating Tablets |
| title_full_unstemmed | Development and Evaluation of Ondansetron Orally Disintegrating Tablets |
| title_short | Development and Evaluation of Ondansetron Orally Disintegrating Tablets |
| title_sort | development and evaluation of ondansetron orally disintegrating tablets |
| topic | orally disintegrating tablets sweeteners superdisintegrants ondansetron |
| url | https://www.bjpharm.org.uk/article/id/548/ |
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