Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty
PurposeSex hormone-binding globulin (SHBG) modulates the availability of biologically active free sex hormones. The regulatory role of SHBG might be important in the relationship between hormone levels and the modification of lipid profiles in girls with precocious puberty. However, few studies have...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2013-06-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-18-81.pdf |
| _version_ | 1818853100068274176 |
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| author | Hyun-Wook Chae Ah-Reum Kwon Duk-Hee Kim Ho-Seong Kim |
| author_facet | Hyun-Wook Chae Ah-Reum Kwon Duk-Hee Kim Ho-Seong Kim |
| author_sort | Hyun-Wook Chae |
| collection | DOAJ |
| description | PurposeSex hormone-binding globulin (SHBG) modulates the availability of biologically active free sex hormones. The regulatory role of SHBG might be important in the relationship between hormone levels and the modification of lipid profiles in girls with precocious puberty. However, few studies have evaluated the relationship of SHBG, free estradiol index (FEI), and lipid levels in these girls.MethodsOne hundred and nine girls less than 8 years of age with pubertal development were enrolled. FEI was calculated with SHBG and estradiol (E2). We analyzed SHBG between peak luteinizing hormone (LH)≥5 (IU/L) (group 1) and LH<5 (IU/L) (group 2) through a gonadotropin releasing hormone stimulation test.ResultsBody mass index (BMI) standard deviation score (SDS) was higher in group 2 than in group 1 (P=0.004). Serum SHBG levels did not differ and FEI was not higher in group 1 (P=0.122). Serum cholesterol, HDL, and LDL did not differ; however, triglyceride levels were higher in group 2 (P=0.023). SHBG was negatively correlated with bone age advancement, BMI, BMI SDS, and FEI, and was positively correlated with HDL. However, SHBG was not correlated with E2 or peak LH.ConclusionSerum SHBG itself might not be associated with precocious puberty in girls, but it might be related to BMI and lipid profiles. Further studies are needed to reveal the relationship between sex hormone and obesity in girls with precocious puberty. |
| first_indexed | 2024-12-19T07:31:26Z |
| format | Article |
| id | doaj.art-170be61e9700403f8cb49cdf291d8675 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-19T07:31:26Z |
| publishDate | 2013-06-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-170be61e9700403f8cb49cdf291d86752022-12-21T20:30:41ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922013-06-01182818410.6065/apem.2013.18.2.81529Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious pubertyHyun-Wook Chae0Ah-Reum Kwon1Duk-Hee Kim2Ho-Seong Kim3Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.Sowha Children's Hospital, Seoul, Korea.Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.PurposeSex hormone-binding globulin (SHBG) modulates the availability of biologically active free sex hormones. The regulatory role of SHBG might be important in the relationship between hormone levels and the modification of lipid profiles in girls with precocious puberty. However, few studies have evaluated the relationship of SHBG, free estradiol index (FEI), and lipid levels in these girls.MethodsOne hundred and nine girls less than 8 years of age with pubertal development were enrolled. FEI was calculated with SHBG and estradiol (E2). We analyzed SHBG between peak luteinizing hormone (LH)≥5 (IU/L) (group 1) and LH<5 (IU/L) (group 2) through a gonadotropin releasing hormone stimulation test.ResultsBody mass index (BMI) standard deviation score (SDS) was higher in group 2 than in group 1 (P=0.004). Serum SHBG levels did not differ and FEI was not higher in group 1 (P=0.122). Serum cholesterol, HDL, and LDL did not differ; however, triglyceride levels were higher in group 2 (P=0.023). SHBG was negatively correlated with bone age advancement, BMI, BMI SDS, and FEI, and was positively correlated with HDL. However, SHBG was not correlated with E2 or peak LH.ConclusionSerum SHBG itself might not be associated with precocious puberty in girls, but it might be related to BMI and lipid profiles. Further studies are needed to reveal the relationship between sex hormone and obesity in girls with precocious puberty.http://e-apem.org/upload/pdf/apem-18-81.pdfSex hormone-binding globulinEstradiolLipidPrecocious puberty |
| spellingShingle | Hyun-Wook Chae Ah-Reum Kwon Duk-Hee Kim Ho-Seong Kim Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty Annals of Pediatric Endocrinology & Metabolism Sex hormone-binding globulin Estradiol Lipid Precocious puberty |
| title | Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty |
| title_full | Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty |
| title_fullStr | Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty |
| title_full_unstemmed | Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty |
| title_short | Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty |
| title_sort | sex hormone binding globulin free estradiol index and lipid profiles in girls with precocious puberty |
| topic | Sex hormone-binding globulin Estradiol Lipid Precocious puberty |
| url | http://e-apem.org/upload/pdf/apem-18-81.pdf |
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