Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology
Yi-Ling Jiang, Yi Xun Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of ChinaCorrespondence: Yi Xun, Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South Chin...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-02-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/molecular-mechanism-of-salvia-miltiorrhiza-in-the-treatment-of-colorec-peer-reviewed-fulltext-article-DDDT |
| _version_ | 1797311695988719616 |
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| author | Jiang YL Xun Y |
| author_facet | Jiang YL Xun Y |
| author_sort | Jiang YL |
| collection | DOAJ |
| description | Yi-Ling Jiang, Yi Xun Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of ChinaCorrespondence: Yi Xun, Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of China, Tel +8618773486975, Email 469239341@qq.comPurpose: This study aimed to investigate the effect of Salvia miltiorrhiza on colorectal cancer, as well as the mechanisms involved.Methods: The active compounds of Salvia miltiorrhiza and the associated genes in colorectal cancer were sourced from publicly available databases. Targets associated with colorectal cancer were identified by searching the GeneCards and OMIM databases. Subsequently, the Cytoscape 3.6.0 software was employed to create a regulatory network that illustrates the relationships among active ingredients, colorectal cancer, and their corresponding targets. The String database was utilized to generate a PPI network. Molecular docking studies, conducted with AutoDock Vina, verified the binding capabilities of these active components to core targets. The findings from network pharmacology analysis were corroborated through in vitro experiments.Results: In this study, we identified 39 active components derived from Salvia miltiorrhiza that are predicted to target 544 genes associated with colorectal cancer through network pharmacology. Through a combined analysis of network pharmacology, we isolated three key targets: SRC, IL6, and INS. Molecular docking results convincingly demonstrated Salvia miltiorrhiza’s strong binding affinity to these targets. Additionally, in vitro experiments confirmed that Salvia miltiorrhiza effectively inhibited the progression of colorectal cancer via regulating the INS/SRC/IL6 pathway.Conclusion: Salvia miltiorrhiza emerges as a compelling herbal intervention for colorectal cancer. This study lays the foundation for potential future clinical trials assessing the efficacy of Salvia miltiorrhiza in the management of colorectal cancer.Keywords: Salvia miltiorrhiza, network pharmacology, traditional Chinese medicine, docking technology, colorectal cancer |
| first_indexed | 2024-03-08T02:04:29Z |
| format | Article |
| id | doaj.art-170d0d9d7fba4fe8bcfeb681322a5bd4 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-03-08T02:04:29Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-170d0d9d7fba4fe8bcfeb681322a5bd42024-02-13T19:43:10ZengDove Medical PressDrug Design, Development and Therapy1177-88812024-02-01Volume 1842544190400Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking TechnologyJiang YLXun YYi-Ling Jiang, Yi Xun Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of ChinaCorrespondence: Yi Xun, Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of China, Tel +8618773486975, Email 469239341@qq.comPurpose: This study aimed to investigate the effect of Salvia miltiorrhiza on colorectal cancer, as well as the mechanisms involved.Methods: The active compounds of Salvia miltiorrhiza and the associated genes in colorectal cancer were sourced from publicly available databases. Targets associated with colorectal cancer were identified by searching the GeneCards and OMIM databases. Subsequently, the Cytoscape 3.6.0 software was employed to create a regulatory network that illustrates the relationships among active ingredients, colorectal cancer, and their corresponding targets. The String database was utilized to generate a PPI network. Molecular docking studies, conducted with AutoDock Vina, verified the binding capabilities of these active components to core targets. The findings from network pharmacology analysis were corroborated through in vitro experiments.Results: In this study, we identified 39 active components derived from Salvia miltiorrhiza that are predicted to target 544 genes associated with colorectal cancer through network pharmacology. Through a combined analysis of network pharmacology, we isolated three key targets: SRC, IL6, and INS. Molecular docking results convincingly demonstrated Salvia miltiorrhiza’s strong binding affinity to these targets. Additionally, in vitro experiments confirmed that Salvia miltiorrhiza effectively inhibited the progression of colorectal cancer via regulating the INS/SRC/IL6 pathway.Conclusion: Salvia miltiorrhiza emerges as a compelling herbal intervention for colorectal cancer. This study lays the foundation for potential future clinical trials assessing the efficacy of Salvia miltiorrhiza in the management of colorectal cancer.Keywords: Salvia miltiorrhiza, network pharmacology, traditional Chinese medicine, docking technology, colorectal cancerhttps://www.dovepress.com/molecular-mechanism-of-salvia-miltiorrhiza-in-the-treatment-of-colorec-peer-reviewed-fulltext-article-DDDTsalvia miltiorrhizanetwork pharmacologytraditional chinese medicinedocking technologycolorectal cancer |
| spellingShingle | Jiang YL Xun Y Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology Drug Design, Development and Therapy salvia miltiorrhiza network pharmacology traditional chinese medicine docking technology colorectal cancer |
| title | Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology |
| title_full | Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology |
| title_fullStr | Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology |
| title_full_unstemmed | Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology |
| title_short | Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology |
| title_sort | molecular mechanism of salvia miltiorrhiza in the treatment of colorectal cancer based on network pharmacology and molecular docking technology |
| topic | salvia miltiorrhiza network pharmacology traditional chinese medicine docking technology colorectal cancer |
| url | https://www.dovepress.com/molecular-mechanism-of-salvia-miltiorrhiza-in-the-treatment-of-colorec-peer-reviewed-fulltext-article-DDDT |
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