Effect of low-dose hydrocortisone and inhaled nitric oxide on inflammatory mediators and local pulmonary metalloproteinases activity in LPS-induced sepsis in piglets

Effect of low-dose hydrocortisone and inhaled nitric oxide on inflammatory mediators and local pulmonary metalloproteinases activity in LPS-induced sepsis in piglets

Abstract Hospital mortality in sepsis varies between 30–45%. It has been shown that administration of inhaled nitric oxide (iNO) and intravenous corticosteroid in a porcine endotoxemia model attenuated the systemic inflammatory response. We explored the anti-inflammatory effect of a double-treatment...

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Bibliographic Details
Main Authors: Liliana Kiczak, Urszula Pasławska, Waldemar Goździk, Barbara Adamik, Marzena Zielińska, Stanisław Zieliński, Kacper Nowak, Michał Płóciennik, Jacek Bania, Aleksandra Tabiś, Marcin Nowak, Robert Pasławski, Claes Frostell
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-38311-6

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