Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery
Recently, the fast development of hybrid nanogels dedicated to various applications has been seen. In this context, nanogels incorporating biomolecules into their nanonetworks are promising innovative carriers that gain great potential in biomedical applications. Hybrid nanogels containing various t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/10/1873 |
| _version_ | 1818909536915816448 |
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| author | Iwona Stanislawska Wioletta Liwinska Marek Lyp Zbigniew Stojek Ewelina Zabost |
| author_facet | Iwona Stanislawska Wioletta Liwinska Marek Lyp Zbigniew Stojek Ewelina Zabost |
| author_sort | Iwona Stanislawska |
| collection | DOAJ |
| description | Recently, the fast development of hybrid nanogels dedicated to various applications has been seen. In this context, nanogels incorporating biomolecules into their nanonetworks are promising innovative carriers that gain great potential in biomedical applications. Hybrid nanogels containing various types of biomolecules are exclusively designed for: improved and controlled release of drugs, targeted delivery, improvement of biocompatibility, and overcoming of immunological response and cell self-defense. This review provides recent advances in this rapidly developing field and concentrates on: (1) the key physical consequences of using hybrid nanogels and introduction of biomolecules; (2) the construction and functionalization of degradable hybrid nanogels; (3) the advantages of hybrid nanogels in controlled and targeted delivery; and (4) the analysis of the specificity of drug release mechanisms in hybrid nanogels. The limitations and future directions of hybrid nanogels in targeted specific- and real-time delivery are also discussed. |
| first_indexed | 2024-12-19T22:28:29Z |
| format | Article |
| id | doaj.art-170f87c3cf4d41009ff291bc50e79f64 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T22:28:29Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-170f87c3cf4d41009ff291bc50e79f642022-12-21T20:03:24ZengMDPI AGMolecules1420-30492019-05-012410187310.3390/molecules24101873molecules24101873Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted DeliveryIwona Stanislawska0Wioletta Liwinska1Marek Lyp2Zbigniew Stojek3Ewelina Zabost4Department of Nutrition, College of Rehabilitation, Kasprzaka 49, 01-234 Warsaw, PolandFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, PolandDepartment of Nutrition, College of Rehabilitation, Kasprzaka 49, 01-234 Warsaw, PolandFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, PolandFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, PolandRecently, the fast development of hybrid nanogels dedicated to various applications has been seen. In this context, nanogels incorporating biomolecules into their nanonetworks are promising innovative carriers that gain great potential in biomedical applications. Hybrid nanogels containing various types of biomolecules are exclusively designed for: improved and controlled release of drugs, targeted delivery, improvement of biocompatibility, and overcoming of immunological response and cell self-defense. This review provides recent advances in this rapidly developing field and concentrates on: (1) the key physical consequences of using hybrid nanogels and introduction of biomolecules; (2) the construction and functionalization of degradable hybrid nanogels; (3) the advantages of hybrid nanogels in controlled and targeted delivery; and (4) the analysis of the specificity of drug release mechanisms in hybrid nanogels. The limitations and future directions of hybrid nanogels in targeted specific- and real-time delivery are also discussed.https://www.mdpi.com/1420-3049/24/10/1873controlled releasetargeted deliveryhybrid nanogelsbiomolecule–hydrogel nanocompositesdrug delivery systemssmart materialshigh-drug loadingon–off systemsremotely controlled release |
| spellingShingle | Iwona Stanislawska Wioletta Liwinska Marek Lyp Zbigniew Stojek Ewelina Zabost Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery Molecules controlled release targeted delivery hybrid nanogels biomolecule–hydrogel nanocomposites drug delivery systems smart materials high-drug loading on–off systems remotely controlled release |
| title | Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery |
| title_full | Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery |
| title_fullStr | Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery |
| title_full_unstemmed | Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery |
| title_short | Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery |
| title_sort | recent advances in degradable hybrids of biomolecules and ngs for targeted delivery |
| topic | controlled release targeted delivery hybrid nanogels biomolecule–hydrogel nanocomposites drug delivery systems smart materials high-drug loading on–off systems remotely controlled release |
| url | https://www.mdpi.com/1420-3049/24/10/1873 |
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