Comparison of Histoacryl® plus Lipiodol® versus Histoacryl® plus vitamin D3 in the management of isolated fundal varices: A retrospective comparative study
Objective: According to recent guidelines Histoacryl® (N-butyl-2 -Cyanoacrylate) injection is the first line therapy for the endoscopic obliteration of gastric varices. Lipiodol is commonly used to facilitate injection Histoacryl® but it is expensive. In this study we compare Lipiodol with Vitamin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2022-03-01
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| Series: | Journal of Rawalpindi Medical College |
| Subjects: | |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/1676 |
| _version_ | 1797989810537758720 |
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| author | Dilaram Khan Naveed Aamir Muhammad Kamran Hassan Farman Ali Fakhare Alam Hashmatullah Khan |
| author_facet | Dilaram Khan Naveed Aamir Muhammad Kamran Hassan Farman Ali Fakhare Alam Hashmatullah Khan |
| author_sort | Dilaram Khan |
| collection | DOAJ |
| description |
Objective: According to recent guidelines Histoacryl® (N-butyl-2 -Cyanoacrylate) injection is the first line therapy for the endoscopic obliteration of gastric varices. Lipiodol is commonly used to facilitate injection Histoacryl® but it is expensive. In this study we compare Lipiodol with Vitamin D3 injection as priming agents for Histoacryl injection in terms of efficacy and safety in the management of isolated fundal varices.
Methods: This is a retrospective comparative study conducted at Gastroenterology Unit, Lady Reading hospital Peshawar. Patients’ information was collected from March, 2012 to January, 2020 from medical records and statistically analyzed in terms of fundal varices obliteration, re-bleeding, mortality, and adverse events related to treatment.
Results: From March, 2012 to January, 2020, 171 patients met the criteria. 7 cases lost follow up, and all the cases in both groups were treated successfully. There were no adverse events related to procedure in either group. Twenty six patients developed upper GI re-bleeding, which did not differ significantly betweenthe twogroups. There was also no difference between the groups in terms of treatment failure, complications, varices obliteration, and mortality.
Conclusion: Vitamin D3 is as safe and effective as Lipoidol when used as priming agent for Histoacryl injection for obliteration of isolated fundal varices and can be used as a cheaper alternative to Lipoidol.
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| first_indexed | 2024-04-11T08:26:26Z |
| format | Article |
| id | doaj.art-1710ca5eb59f42e3a3914b8bbdd509b7 |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-04-11T08:26:26Z |
| publishDate | 2022-03-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-1710ca5eb59f42e3a3914b8bbdd509b72022-12-22T04:34:44ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702022-03-0126110.37939/jrmc.v26i1.1676Comparison of Histoacryl® plus Lipiodol® versus Histoacryl® plus vitamin D3 in the management of isolated fundal varices: A retrospective comparative studyDilaram Khan0Naveed Aamir1Muhammad Kamran HassanFarman Ali2Fakhare AlamHashmatullah Khan3Gastroenterology Department, LRH, PeshawarGastroenterology Department, LRH, PeshawarGastroenterology Department, LRH, PeshawarGastroenterology Department, LRH, Peshawar Objective: According to recent guidelines Histoacryl® (N-butyl-2 -Cyanoacrylate) injection is the first line therapy for the endoscopic obliteration of gastric varices. Lipiodol is commonly used to facilitate injection Histoacryl® but it is expensive. In this study we compare Lipiodol with Vitamin D3 injection as priming agents for Histoacryl injection in terms of efficacy and safety in the management of isolated fundal varices. Methods: This is a retrospective comparative study conducted at Gastroenterology Unit, Lady Reading hospital Peshawar. Patients’ information was collected from March, 2012 to January, 2020 from medical records and statistically analyzed in terms of fundal varices obliteration, re-bleeding, mortality, and adverse events related to treatment. Results: From March, 2012 to January, 2020, 171 patients met the criteria. 7 cases lost follow up, and all the cases in both groups were treated successfully. There were no adverse events related to procedure in either group. Twenty six patients developed upper GI re-bleeding, which did not differ significantly betweenthe twogroups. There was also no difference between the groups in terms of treatment failure, complications, varices obliteration, and mortality. Conclusion: Vitamin D3 is as safe and effective as Lipoidol when used as priming agent for Histoacryl injection for obliteration of isolated fundal varices and can be used as a cheaper alternative to Lipoidol. https://www.journalrmc.com/index.php/JRMC/article/view/1676Fundal varices, Histoacryl (N-butyl-2 -Cyanoacrylate), Vitamin D3, Lipoidol |
| spellingShingle | Dilaram Khan Naveed Aamir Muhammad Kamran Hassan Farman Ali Fakhare Alam Hashmatullah Khan Comparison of Histoacryl® plus Lipiodol® versus Histoacryl® plus vitamin D3 in the management of isolated fundal varices: A retrospective comparative study Journal of Rawalpindi Medical College Fundal varices, Histoacryl (N-butyl-2 -Cyanoacrylate), Vitamin D3, Lipoidol |
| title | Comparison of Histoacryl® plus Lipiodol® versus Histoacryl® plus vitamin D3 in the management of isolated fundal varices: A retrospective comparative study |
| title_full | Comparison of Histoacryl® plus Lipiodol® versus Histoacryl® plus vitamin D3 in the management of isolated fundal varices: A retrospective comparative study |
| title_fullStr | Comparison of Histoacryl® plus Lipiodol® versus Histoacryl® plus vitamin D3 in the management of isolated fundal varices: A retrospective comparative study |
| title_full_unstemmed | Comparison of Histoacryl® plus Lipiodol® versus Histoacryl® plus vitamin D3 in the management of isolated fundal varices: A retrospective comparative study |
| title_short | Comparison of Histoacryl® plus Lipiodol® versus Histoacryl® plus vitamin D3 in the management of isolated fundal varices: A retrospective comparative study |
| title_sort | comparison of histoacryl r plus lipiodol r versus histoacryl r plus vitamin d3 in the management of isolated fundal varices a retrospective comparative study |
| topic | Fundal varices, Histoacryl (N-butyl-2 -Cyanoacrylate), Vitamin D3, Lipoidol |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/1676 |
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