The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia
Background. To study the frequency of the fibrinogen gene (G(–455)A) FGB polymorphisms in pregnant women with hypercoagulemia in severe preeclampsia (PE). Materials and methods. On the basis of the perinatal center of the “Mordovia Republican Central Clinical Hospital” from 2015 to 2020, a prospe...
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| Format: | Article |
| Language: | English |
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Penza State University Publishing House
2022-06-01
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| Series: | Известия высших учебных заведений. Поволжский регион: Медицинские науки |
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| _version_ | 1828775469651066880 |
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| author | T.I. Vlasova V.A. Trofimov E.V. Arsent'eva A.V. Sitdikova T.I. Shishkanova |
| author_facet | T.I. Vlasova V.A. Trofimov E.V. Arsent'eva A.V. Sitdikova T.I. Shishkanova |
| author_sort | T.I. Vlasova |
| collection | DOAJ |
| description | Background. To study the frequency of the fibrinogen gene (G(–455)A) FGB
polymorphisms in pregnant women with hypercoagulemia in severe preeclampsia (PE).
Materials and methods. On the basis of the perinatal center of the “Mordovia Republican
Central Clinical Hospital” from 2015 to 2020, a prospective study of 2 groups of pregnant
women aged 18 to 40 years was conducted for a period from 22 to 41 weeks of gestation:
group I (control) – 52 women with physiological course of pregnancy, group II (main) – 58
patients with severe PE. A complex of studies was carried out, including: clinical, laboratory
(complet blood count, hemostasiogram), special methods (genotyping of polymorphisms
of the investigated fibrinogen gene FGB (G(–455)A) by PCR-method Real-time PCR), as
well as thromboelastography of whole blood and assessment of microcirculation peripheral
tissues. Results. In pregnant women with severe preeclampsia, a high prevalence of heterozygous
(C/A) and homozygous (A/A) variants (48.3 and 36.2 %) of the FGB fibrinogen
gene (G(–455)A), a pronounced imbalance between the processes fibrinogenesis and fibrinolysis,
an increase in the amount of fibrinogen, as well as a decrease in the content of antithrombin
III and the number of platelets, the pathological nature of thrombus formation
and an increased relative strength and rate of blood clot formation were noted. Conclusions.
The data obtained indicate the important role of the fibrinogen gene polymorphism (G(–
455)A) FGB) in the implementation of the pathological hypercoagulability pathogenesis
in severe preeclampsia, which contributes to the occurrence of vascular microthrombosis
and further aggravation of endothelial damage and the progression of microcirculatory disorders. |
| first_indexed | 2024-12-11T15:40:49Z |
| format | Article |
| id | doaj.art-171183a834d149f390dfddf27ec40266 |
| institution | Directory Open Access Journal |
| issn | 2072-3032 |
| language | English |
| last_indexed | 2024-12-11T15:40:49Z |
| publishDate | 2022-06-01 |
| publisher | Penza State University Publishing House |
| record_format | Article |
| series | Известия высших учебных заведений. Поволжский регион: Медицинские науки |
| spelling | doaj.art-171183a834d149f390dfddf27ec402662022-12-22T00:59:49ZengPenza State University Publishing HouseИзвестия высших учебных заведений. Поволжский регион: Медицинские науки2072-30322022-06-01210.21685/2072-3032-2022-2-16The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemiaT.I. Vlasova0V.A. Trofimov1E.V. Arsent'eva2A.V. Sitdikova3T.I. Shishkanova4Ogarev Mordovia State UniversityOgarev Mordovia State UniversityOgarev Mordovia State UniversityOgarev Mordovia State UniversityOgarev Mordovia State UniversityBackground. To study the frequency of the fibrinogen gene (G(–455)A) FGB polymorphisms in pregnant women with hypercoagulemia in severe preeclampsia (PE). Materials and methods. On the basis of the perinatal center of the “Mordovia Republican Central Clinical Hospital” from 2015 to 2020, a prospective study of 2 groups of pregnant women aged 18 to 40 years was conducted for a period from 22 to 41 weeks of gestation: group I (control) – 52 women with physiological course of pregnancy, group II (main) – 58 patients with severe PE. A complex of studies was carried out, including: clinical, laboratory (complet blood count, hemostasiogram), special methods (genotyping of polymorphisms of the investigated fibrinogen gene FGB (G(–455)A) by PCR-method Real-time PCR), as well as thromboelastography of whole blood and assessment of microcirculation peripheral tissues. Results. In pregnant women with severe preeclampsia, a high prevalence of heterozygous (C/A) and homozygous (A/A) variants (48.3 and 36.2 %) of the FGB fibrinogen gene (G(–455)A), a pronounced imbalance between the processes fibrinogenesis and fibrinolysis, an increase in the amount of fibrinogen, as well as a decrease in the content of antithrombin III and the number of platelets, the pathological nature of thrombus formation and an increased relative strength and rate of blood clot formation were noted. Conclusions. The data obtained indicate the important role of the fibrinogen gene polymorphism (G(– 455)A) FGB) in the implementation of the pathological hypercoagulability pathogenesis in severe preeclampsia, which contributes to the occurrence of vascular microthrombosis and further aggravation of endothelial damage and the progression of microcirculatory disorders.hemostasis systemgenotypepolymorphismpreeclampsia |
| spellingShingle | T.I. Vlasova V.A. Trofimov E.V. Arsent'eva A.V. Sitdikova T.I. Shishkanova The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia Известия высших учебных заведений. Поволжский регион: Медицинские науки hemostasis system genotype polymorphism preeclampsia |
| title | The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia |
| title_full | The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia |
| title_fullStr | The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia |
| title_full_unstemmed | The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia |
| title_short | The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia |
| title_sort | role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia |
| topic | hemostasis system genotype polymorphism preeclampsia |
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