Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes

Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes

<p>Abstract</p> <p>MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabe...

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Bibliographic Details
Main Authors: Mi Xiaofan, He Hongzhi, Deng Yangxin, Levin Abert M, She Jin-Xiong, Mi Qing-Sheng, Zhou Li
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Type 1 diabetes
polymorphism
microRNAs
Online Access:http://www.dmsjournal.com/content/3/1/27
Description
Summary:<p>Abstract</p> <p>MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/<it>A</it>]CCC) of miRNA <it>miR-938 </it>and potentially alters <it>miR-938 </it>targets, including IL-16 and IL-17A. In an attempt to test whether <it>miR-938 </it>may be a susceptibility gene for IDDM10, we assessed the possible association of the <it>miR-938 </it>SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in <it>miR-938 </it>and type 1 diabetes.</p>
ISSN:1758-5996

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