Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes
<p>Abstract</p> <p>MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-10-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://www.dmsjournal.com/content/3/1/27 |
| _version_ | 1828299776989331456 |
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| author | Mi Xiaofan He Hongzhi Deng Yangxin Levin Abert M She Jin-Xiong Mi Qing-Sheng Zhou Li |
| author_facet | Mi Xiaofan He Hongzhi Deng Yangxin Levin Abert M She Jin-Xiong Mi Qing-Sheng Zhou Li |
| author_sort | Mi Xiaofan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/<it>A</it>]CCC) of miRNA <it>miR-938 </it>and potentially alters <it>miR-938 </it>targets, including IL-16 and IL-17A. In an attempt to test whether <it>miR-938 </it>may be a susceptibility gene for IDDM10, we assessed the possible association of the <it>miR-938 </it>SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in <it>miR-938 </it>and type 1 diabetes.</p> |
| first_indexed | 2024-04-13T12:59:14Z |
| format | Article |
| id | doaj.art-17121484c20c4f6da584d266c0ff6ee2 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-13T12:59:14Z |
| publishDate | 2011-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-17121484c20c4f6da584d266c0ff6ee22022-12-22T02:45:57ZengBMCDiabetology & Metabolic Syndrome1758-59962011-10-01312710.1186/1758-5996-3-27Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetesMi XiaofanHe HongzhiDeng YangxinLevin Abert MShe Jin-XiongMi Qing-ShengZhou Li<p>Abstract</p> <p>MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/<it>A</it>]CCC) of miRNA <it>miR-938 </it>and potentially alters <it>miR-938 </it>targets, including IL-16 and IL-17A. In an attempt to test whether <it>miR-938 </it>may be a susceptibility gene for IDDM10, we assessed the possible association of the <it>miR-938 </it>SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in <it>miR-938 </it>and type 1 diabetes.</p>http://www.dmsjournal.com/content/3/1/27Type 1 diabetespolymorphismmicroRNAs |
| spellingShingle | Mi Xiaofan He Hongzhi Deng Yangxin Levin Abert M She Jin-Xiong Mi Qing-Sheng Zhou Li Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes Diabetology & Metabolic Syndrome Type 1 diabetes polymorphism microRNAs |
| title | Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes |
| title_full | Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes |
| title_fullStr | Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes |
| title_full_unstemmed | Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes |
| title_short | Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes |
| title_sort | lack of an association of it mir 938 it snp in iddm10 with human type 1 diabetes |
| topic | Type 1 diabetes polymorphism microRNAs |
| url | http://www.dmsjournal.com/content/3/1/27 |
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