Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys
The use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes as well as to decrease organ discard rate. With oxygenation proposed as a resuscitative measure during hypothermic machine preservation, th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/8/993 |
| _version_ | 1797524557064568832 |
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| author | Tom Darius Jay Nath Michel Mourad |
| author_facet | Tom Darius Jay Nath Michel Mourad |
| author_sort | Tom Darius |
| collection | DOAJ |
| description | The use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes as well as to decrease organ discard rate. With oxygenation proposed as a resuscitative measure during hypothermic machine preservation, this review provides a critical overview of the fundamentals of active oxygenation during hypothermic machine perfusion, as well as the current preclinical and clinical evidence and suggests different strategies for clinical implementation. |
| first_indexed | 2024-03-10T08:59:07Z |
| format | Article |
| id | doaj.art-171333d6616b4f7484dc3d2f23f92d05 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T08:59:07Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-171333d6616b4f7484dc3d2f23f92d052023-11-22T06:53:04ZengMDPI AGBiomedicines2227-90592021-08-019899310.3390/biomedicines9080993Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for KidneysTom Darius0Jay Nath1Michel Mourad2Surgery and Abdominal Transplant Unit, University Clinics Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Renal Transplantation, Southmead Hospital Bristol, Bristol BS10 5NB, UKSurgery and Abdominal Transplant Unit, University Clinics Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumThe use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes as well as to decrease organ discard rate. With oxygenation proposed as a resuscitative measure during hypothermic machine preservation, this review provides a critical overview of the fundamentals of active oxygenation during hypothermic machine perfusion, as well as the current preclinical and clinical evidence and suggests different strategies for clinical implementation.https://www.mdpi.com/2227-9059/9/8/993hypothermic machine perfusionkidney transplantationoxygenationmitochondriaorgan preservationkidney assessment |
| spellingShingle | Tom Darius Jay Nath Michel Mourad Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys Biomedicines hypothermic machine perfusion kidney transplantation oxygenation mitochondria organ preservation kidney assessment |
| title | Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys |
| title_full | Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys |
| title_fullStr | Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys |
| title_full_unstemmed | Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys |
| title_short | Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys |
| title_sort | simply adding oxygen during hypothermic machine perfusion to combat the negative effects of ischemia reperfusion injury fundamentals and current evidence for kidneys |
| topic | hypothermic machine perfusion kidney transplantation oxygenation mitochondria organ preservation kidney assessment |
| url | https://www.mdpi.com/2227-9059/9/8/993 |
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