Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo
The rate of resorption of calcium phosphate self-hardening materials for bone regeneration can be changed by changing the phase composition. The Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>/CaCO<sub>3</sub>/Ca(H<sub>2</sub>PO<sub>4</...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Ceramics |
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| Online Access: | https://www.mdpi.com/2571-6131/6/3/86 |
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| author | Yulia Lukina Leonid Bionyshev-Abramov Sergey Kotov Natalya Serejnikova Dmitriiy Smolentsev Sergey Sivkov |
| author_facet | Yulia Lukina Leonid Bionyshev-Abramov Sergey Kotov Natalya Serejnikova Dmitriiy Smolentsev Sergey Sivkov |
| author_sort | Yulia Lukina |
| collection | DOAJ |
| description | The rate of resorption of calcium phosphate self-hardening materials for bone regeneration can be changed by changing the phase composition. The Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>/CaCO<sub>3</sub>/Ca(H<sub>2</sub>PO<sub>4</sub>)<sub>2</sub>·H<sub>2</sub>O/Na<sub>2</sub>HPO<sub>4</sub>·12H<sub>2</sub>O system is important for the synthesis of self-curing bioactive materials with variable resorption rates by changing the ratios of the initial components. Cement compositions in twelve figurative points of a four-component composition diagram at a fixed content in the α-Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> system were studied with XRD, FTIR, SEM, calorimetric, and volumetric methods to obtain an idea of the effect of composition on solubility in vitro and resorption in vivo. It was found that the presence of the highly resorbable phase of dicalcium phosphate dihydrate in cement and the substitution of phosphate ions with the carbonate ions of hydroxyapatite increased solubility in vitro and resorption in vivo. The obtained results confirm the possibility of changing the solubility of a final product in the Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>/CaCO<sub>3</sub>/Ca(H<sub>2</sub>PO<sub>4</sub>)<sub>2</sub>·H<sub>2</sub>O/Na<sub>2</sub>HPO<sub>4</sub>·12H<sub>2</sub>O system by changing the ratio of the initial components. |
| first_indexed | 2024-03-10T22:55:58Z |
| format | Article |
| id | doaj.art-1715afa08f664ba6bad1c96a309f28e0 |
| institution | Directory Open Access Journal |
| issn | 2571-6131 |
| language | English |
| last_indexed | 2024-03-10T22:55:58Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Ceramics |
| spelling | doaj.art-1715afa08f664ba6bad1c96a309f28e02023-11-19T10:00:37ZengMDPI AGCeramics2571-61312023-07-01631397141410.3390/ceramics6030086Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In VivoYulia Lukina0Leonid Bionyshev-Abramov1Sergey Kotov2Natalya Serejnikova3Dmitriiy Smolentsev4Sergey Sivkov5National Medical Research Center for Traumatology and Orthopedics Named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, RussiaNational Medical Research Center for Traumatology and Orthopedics Named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, RussiaExperimental Tests Preparation and Carry Out Department No. 29, Research Institute of Concrete and Reinforced Concrete (NIIZHB) A.A. Gvozdev, JSC Research Center of Construction, 2nd Institutskaya Str., 6, 109428 Moscow, RussiaNational Medical Research Center for Traumatology and Orthopedics Named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, RussiaNational Medical Research Center for Traumatology and Orthopedics Named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, RussiaFaculty of Technology of Inorganic Substances and High-Temperature Materials, Mendeleev University of Chemical Technology of Russia, Miusskaya Pl. 9, 125047 Moscow, RussiaThe rate of resorption of calcium phosphate self-hardening materials for bone regeneration can be changed by changing the phase composition. The Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>/CaCO<sub>3</sub>/Ca(H<sub>2</sub>PO<sub>4</sub>)<sub>2</sub>·H<sub>2</sub>O/Na<sub>2</sub>HPO<sub>4</sub>·12H<sub>2</sub>O system is important for the synthesis of self-curing bioactive materials with variable resorption rates by changing the ratios of the initial components. Cement compositions in twelve figurative points of a four-component composition diagram at a fixed content in the α-Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> system were studied with XRD, FTIR, SEM, calorimetric, and volumetric methods to obtain an idea of the effect of composition on solubility in vitro and resorption in vivo. It was found that the presence of the highly resorbable phase of dicalcium phosphate dihydrate in cement and the substitution of phosphate ions with the carbonate ions of hydroxyapatite increased solubility in vitro and resorption in vivo. The obtained results confirm the possibility of changing the solubility of a final product in the Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>/CaCO<sub>3</sub>/Ca(H<sub>2</sub>PO<sub>4</sub>)<sub>2</sub>·H<sub>2</sub>O/Na<sub>2</sub>HPO<sub>4</sub>·12H<sub>2</sub>O system by changing the ratio of the initial components.https://www.mdpi.com/2571-6131/6/3/86hydroxyapatitecarbonate apatitedicalcium phosphate dihydratecalcium phosphatebiomaterialbone cement |
| spellingShingle | Yulia Lukina Leonid Bionyshev-Abramov Sergey Kotov Natalya Serejnikova Dmitriiy Smolentsev Sergey Sivkov Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo Ceramics hydroxyapatite carbonate apatite dicalcium phosphate dihydrate calcium phosphate biomaterial bone cement |
| title | Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo |
| title_full | Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo |
| title_fullStr | Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo |
| title_full_unstemmed | Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo |
| title_short | Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo |
| title_sort | carbonate hydroxyapatite cement the effect of composition on solubility in vitro and resorption in vivo |
| topic | hydroxyapatite carbonate apatite dicalcium phosphate dihydrate calcium phosphate biomaterial bone cement |
| url | https://www.mdpi.com/2571-6131/6/3/86 |
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