Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case Series
Objective: To report nine cases of pediatric patients with Acute Lymphoid Leukemia (ALL) or Acute Myeloid Leukemia who developed severe oral mucositis (SOM) at the first week of chemotherapy. Material and Methods: The cases were selected from a sample of 105 children followed for 10 consecutive week...
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| Format: | Article |
| Language: | English |
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Association of Support to Oral Health Research (APESB)
2023-09-01
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| Series: | Pesquisa Brasileira em Odontopediatria e Clínica Integrada |
| Subjects: | |
| Online Access: | https://revista.uepb.edu.br/PBOCI/article/view/2635 |
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| author | Fabio Gomes dos Santos Paula Maria Maracajá Bezerra Nayara Pereira Limão Ynnaiana Navarro de Lima Santana Isabella Lima Arrais Ribeiro Paulo Rogério Ferreti Bonan Eliane Batista de Medeiros Serpa Simone Alves Sousa Ana Maria Gondim Valença |
| author_facet | Fabio Gomes dos Santos Paula Maria Maracajá Bezerra Nayara Pereira Limão Ynnaiana Navarro de Lima Santana Isabella Lima Arrais Ribeiro Paulo Rogério Ferreti Bonan Eliane Batista de Medeiros Serpa Simone Alves Sousa Ana Maria Gondim Valença |
| author_sort | Fabio Gomes dos Santos |
| collection | DOAJ |
| description | Objective: To report nine cases of pediatric patients with Acute Lymphoid Leukemia (ALL) or Acute Myeloid Leukemia who developed severe oral mucositis (SOM) at the first week of chemotherapy. Material and Methods: The cases were selected from a sample of 105 children followed for 10 consecutive weeks. Hematological and personal data were obtained from the patient's medical records. The oral cavity was examined weekly using the modified Oral Assessment Guide. Results: More of the patients were male (55.6%), had black/brown skin (55.6%), with ALL (66.7%), and the mean age was 5.55. Two patients had values below normal for leukocytes, platelets, and creatinine over the follow-up. However, all patients showed changes in the normality of hematological data in most weeks. The most used chemotherapeutic agents were aracytin, etoposide, and methotrexate, known for their high stomatotoxic potential. Patients had 2 to 6 (mean of 4) episodes of SOM and 4 to 7 (mean of 5.5) episodes of OM. One patient at week 7, one patient at week 5, and one patient at weeks 2 and 10 did not have OM. Saliva (84 times) and lips (44 times) were the most affected items. Conclusion: The patients showed oscillations in the severity of oral mucositis and hematological parameters over the follow-up. All patients were exposed to stomatotoxic drugs during the initial phase of cancer treatment.
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| first_indexed | 2024-03-11T22:36:35Z |
| format | Article |
| id | doaj.art-1715e20637c749c28c3ef01e0b063eec |
| institution | Directory Open Access Journal |
| issn | 1519-0501 1983-4632 |
| language | English |
| last_indexed | 2024-03-11T22:36:35Z |
| publishDate | 2023-09-01 |
| publisher | Association of Support to Oral Health Research (APESB) |
| record_format | Article |
| series | Pesquisa Brasileira em Odontopediatria e Clínica Integrada |
| spelling | doaj.art-1715e20637c749c28c3ef01e0b063eec2023-09-22T12:09:16ZengAssociation of Support to Oral Health Research (APESB)Pesquisa Brasileira em Odontopediatria e Clínica Integrada1519-05011983-46322023-09-0123Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case SeriesFabio Gomes dos SantosPaula Maria Maracajá BezerraNayara Pereira LimãoYnnaiana Navarro de Lima SantanaIsabella Lima Arrais RibeiroPaulo Rogério Ferreti BonanEliane Batista de Medeiros SerpaSimone Alves SousaAna Maria Gondim ValençaObjective: To report nine cases of pediatric patients with Acute Lymphoid Leukemia (ALL) or Acute Myeloid Leukemia who developed severe oral mucositis (SOM) at the first week of chemotherapy. Material and Methods: The cases were selected from a sample of 105 children followed for 10 consecutive weeks. Hematological and personal data were obtained from the patient's medical records. The oral cavity was examined weekly using the modified Oral Assessment Guide. Results: More of the patients were male (55.6%), had black/brown skin (55.6%), with ALL (66.7%), and the mean age was 5.55. Two patients had values below normal for leukocytes, platelets, and creatinine over the follow-up. However, all patients showed changes in the normality of hematological data in most weeks. The most used chemotherapeutic agents were aracytin, etoposide, and methotrexate, known for their high stomatotoxic potential. Patients had 2 to 6 (mean of 4) episodes of SOM and 4 to 7 (mean of 5.5) episodes of OM. One patient at week 7, one patient at week 5, and one patient at weeks 2 and 10 did not have OM. Saliva (84 times) and lips (44 times) were the most affected items. Conclusion: The patients showed oscillations in the severity of oral mucositis and hematological parameters over the follow-up. All patients were exposed to stomatotoxic drugs during the initial phase of cancer treatment. https://revista.uepb.edu.br/PBOCI/article/view/2635MucositisStomatitisHematologic DiseasesDrug Therapy |
| spellingShingle | Fabio Gomes dos Santos Paula Maria Maracajá Bezerra Nayara Pereira Limão Ynnaiana Navarro de Lima Santana Isabella Lima Arrais Ribeiro Paulo Rogério Ferreti Bonan Eliane Batista de Medeiros Serpa Simone Alves Sousa Ana Maria Gondim Valença Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case Series Pesquisa Brasileira em Odontopediatria e Clínica Integrada Mucositis Stomatitis Hematologic Diseases Drug Therapy |
| title | Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case Series |
| title_full | Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case Series |
| title_fullStr | Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case Series |
| title_full_unstemmed | Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case Series |
| title_short | Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case Series |
| title_sort | oral mucositis in children with leukemia undergoing chemotherapy a case series |
| topic | Mucositis Stomatitis Hematologic Diseases Drug Therapy |
| url | https://revista.uepb.edu.br/PBOCI/article/view/2635 |
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