Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation
Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In this study, we performed double-target neural circuit-magnetic stimulation on the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=1062;epage=1066;aulast=Zhao |
| _version_ | 1811220440857706496 |
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| author | Dan Zhao Ye Zhang Ya Zheng Xu-Tong Li Cheng-Cheng Sun Qi Yang Qing Xie Dong-Sheng Xu |
| author_facet | Dan Zhao Ye Zhang Ya Zheng Xu-Tong Li Cheng-Cheng Sun Qi Yang Qing Xie Dong-Sheng Xu |
| author_sort | Dan Zhao |
| collection | DOAJ |
| description | Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In this study, we performed double-target neural circuit-magnetic stimulation on the left motor cortex and bilateral L5 nerve root for 3 successive weeks in a rat model of incomplete spinal cord injury caused by compression at T10. Results showed that in the injured spinal cord, the expression of the astrocyte marker glial fibrillary acidic protein and inflammatory factors interleukin 1β, interleukin-6, and tumor necrosis factor-α had decreased, whereas that of neuronal survival marker microtubule-associated protein 2 and synaptic plasticity markers postsynaptic densification protein 95 and synaptophysin protein had increased. Additionally, neural signaling of the descending corticospinal tract was markedly improved and rat locomotor function recovered significantly. These findings suggest that double-target neural circuit-magnetic stimulation improves rat motor function by attenuating astrocyte activation, thus providing a theoretical basis for application of double-target neural circuit-magnetic stimulation in the clinical treatment of spinal cord injury. |
| first_indexed | 2024-04-12T07:41:50Z |
| format | Article |
| id | doaj.art-1716b8d289bb41dba50c738cdfcc2d21 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-12T07:41:50Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-1716b8d289bb41dba50c738cdfcc2d212022-12-22T03:41:47ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-011851062106610.4103/1673-5374.355768Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activationDan ZhaoYe ZhangYa ZhengXu-Tong LiCheng-Cheng SunQi YangQing XieDong-Sheng XuMulti-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In this study, we performed double-target neural circuit-magnetic stimulation on the left motor cortex and bilateral L5 nerve root for 3 successive weeks in a rat model of incomplete spinal cord injury caused by compression at T10. Results showed that in the injured spinal cord, the expression of the astrocyte marker glial fibrillary acidic protein and inflammatory factors interleukin 1β, interleukin-6, and tumor necrosis factor-α had decreased, whereas that of neuronal survival marker microtubule-associated protein 2 and synaptic plasticity markers postsynaptic densification protein 95 and synaptophysin protein had increased. Additionally, neural signaling of the descending corticospinal tract was markedly improved and rat locomotor function recovered significantly. These findings suggest that double-target neural circuit-magnetic stimulation improves rat motor function by attenuating astrocyte activation, thus providing a theoretical basis for application of double-target neural circuit-magnetic stimulation in the clinical treatment of spinal cord injury.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=1062;epage=1066;aulast=Zhaoastrocyte; inflammatory response; microtubule-associated protein 2; motor function; motor-evoked potential; neural circuit-magnetic stimulation; neural repair; neuromodulation technique; spinal cord injury; synaptic plasticity |
| spellingShingle | Dan Zhao Ye Zhang Ya Zheng Xu-Tong Li Cheng-Cheng Sun Qi Yang Qing Xie Dong-Sheng Xu Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation Neural Regeneration Research astrocyte; inflammatory response; microtubule-associated protein 2; motor function; motor-evoked potential; neural circuit-magnetic stimulation; neural repair; neuromodulation technique; spinal cord injury; synaptic plasticity |
| title | Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation |
| title_full | Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation |
| title_fullStr | Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation |
| title_full_unstemmed | Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation |
| title_short | Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation |
| title_sort | double target neural circuit magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation |
| topic | astrocyte; inflammatory response; microtubule-associated protein 2; motor function; motor-evoked potential; neural circuit-magnetic stimulation; neural repair; neuromodulation technique; spinal cord injury; synaptic plasticity |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=1062;epage=1066;aulast=Zhao |
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