Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde
Abstract Background Many workers are exposed to wood dust (WD) and formaldehyde (FA), whose carcinogenic activity is supposed to be oxidative stress-mediated. This study aims to assess to what extent the occupational exposure to WD and FA, albeit within regulatory limits, could result in OS inductio...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-02-01
|
| Series: | Journal of Occupational Medicine and Toxicology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12995-021-00293-4 |
| _version_ | 1798025949159096320 |
|---|---|
| author | Federica Ghelli Valeria Bellisario Giulia Squillacioti Elena Grignani Giacomo Garzaro Martina Buglisi Enrico Bergamaschi Roberto Bono |
| author_facet | Federica Ghelli Valeria Bellisario Giulia Squillacioti Elena Grignani Giacomo Garzaro Martina Buglisi Enrico Bergamaschi Roberto Bono |
| author_sort | Federica Ghelli |
| collection | DOAJ |
| description | Abstract Background Many workers are exposed to wood dust (WD) and formaldehyde (FA), whose carcinogenic activity is supposed to be oxidative stress-mediated. This study aims to assess to what extent the occupational exposure to WD and FA, albeit within regulatory limits, could result in OS induction in a woodworkers’ population. Methods The sample population consisted of 127 woodworkers from 4 factories and 111 unexposed controls. Individual exposure was assessed by personal air-samplers. Each participant enrolled in the study filled out a questionnaire and provided a urinary sample to quantify OS biomarkers, namely 15-F2t-IsoProstane (15-F2t-IsoP) and 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo). The main confounding factor for OS, i.e. tobacco smoking exposure, was assessed by measuring cotinine in urine samples. Results Woodworkers were exposed to significantly higher amounts of WD and FA as compared to controls (p < 0.001). Among OS biomarkers, 15-F2t-IsoP showed statistically significant higher values in woodworkers compared to controls (p = 0.004). A significant, positive correlation was observed between 15-F2t-IsoP and 8-oxo-dGuo (p = 0.005), cotinine (p = 0.05), FA (p < 0.001) and WD (p = 0.01); 8-oxo-dGuo was significantly correlated with cotinine (p = 0.001) and WD (p = 0.004). In addition, WD and FA were significantly correlated each other (p < 0.001). Conclusions The study confirms that WD and FA may induce OS in woodworkers, and highlights that even the compliance with occupational exposure limits can result in measurable biological outcomes. |
| first_indexed | 2024-04-11T18:28:19Z |
| format | Article |
| id | doaj.art-17171ecf26db45459d616a1d6fcac95a |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-11T18:28:19Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-17171ecf26db45459d616a1d6fcac95a2022-12-22T04:09:33ZengBMCJournal of Occupational Medicine and Toxicology1745-66732021-02-011611910.1186/s12995-021-00293-4Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehydeFederica Ghelli0Valeria Bellisario1Giulia Squillacioti2Elena Grignani3Giacomo Garzaro4Martina Buglisi5Enrico Bergamaschi6Roberto Bono7Department of Public Health and Pediatrics, University of TurinDepartment of Public Health and Pediatrics, University of TurinDepartment of Public Health and Pediatrics, University of TurinMaugeri Scientific Clinical InstitutesDepartment of Public Health and Pediatrics, University of TurinDepartment of Public Health and Pediatrics, University of TurinDepartment of Public Health and Pediatrics, University of TurinDepartment of Public Health and Pediatrics, University of TurinAbstract Background Many workers are exposed to wood dust (WD) and formaldehyde (FA), whose carcinogenic activity is supposed to be oxidative stress-mediated. This study aims to assess to what extent the occupational exposure to WD and FA, albeit within regulatory limits, could result in OS induction in a woodworkers’ population. Methods The sample population consisted of 127 woodworkers from 4 factories and 111 unexposed controls. Individual exposure was assessed by personal air-samplers. Each participant enrolled in the study filled out a questionnaire and provided a urinary sample to quantify OS biomarkers, namely 15-F2t-IsoProstane (15-F2t-IsoP) and 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo). The main confounding factor for OS, i.e. tobacco smoking exposure, was assessed by measuring cotinine in urine samples. Results Woodworkers were exposed to significantly higher amounts of WD and FA as compared to controls (p < 0.001). Among OS biomarkers, 15-F2t-IsoP showed statistically significant higher values in woodworkers compared to controls (p = 0.004). A significant, positive correlation was observed between 15-F2t-IsoP and 8-oxo-dGuo (p = 0.005), cotinine (p = 0.05), FA (p < 0.001) and WD (p = 0.01); 8-oxo-dGuo was significantly correlated with cotinine (p = 0.001) and WD (p = 0.004). In addition, WD and FA were significantly correlated each other (p < 0.001). Conclusions The study confirms that WD and FA may induce OS in woodworkers, and highlights that even the compliance with occupational exposure limits can result in measurable biological outcomes.https://doi.org/10.1186/s12995-021-00293-4Occupational hygieneBiomonitoringEpidemiologyFormaldehydeWood dust |
| spellingShingle | Federica Ghelli Valeria Bellisario Giulia Squillacioti Elena Grignani Giacomo Garzaro Martina Buglisi Enrico Bergamaschi Roberto Bono Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde Journal of Occupational Medicine and Toxicology Occupational hygiene Biomonitoring Epidemiology Formaldehyde Wood dust |
| title | Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde |
| title_full | Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde |
| title_fullStr | Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde |
| title_full_unstemmed | Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde |
| title_short | Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde |
| title_sort | oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde |
| topic | Occupational hygiene Biomonitoring Epidemiology Formaldehyde Wood dust |
| url | https://doi.org/10.1186/s12995-021-00293-4 |
| work_keys_str_mv | AT federicaghelli oxidativestressinductioninwoodworkersoccupationallyexposedtowooddustandformaldehyde AT valeriabellisario oxidativestressinductioninwoodworkersoccupationallyexposedtowooddustandformaldehyde AT giuliasquillacioti oxidativestressinductioninwoodworkersoccupationallyexposedtowooddustandformaldehyde AT elenagrignani oxidativestressinductioninwoodworkersoccupationallyexposedtowooddustandformaldehyde AT giacomogarzaro oxidativestressinductioninwoodworkersoccupationallyexposedtowooddustandformaldehyde AT martinabuglisi oxidativestressinductioninwoodworkersoccupationallyexposedtowooddustandformaldehyde AT enricobergamaschi oxidativestressinductioninwoodworkersoccupationallyexposedtowooddustandformaldehyde AT robertobono oxidativestressinductioninwoodworkersoccupationallyexposedtowooddustandformaldehyde |