An in vitro attempt at precision toxicology reveals the involvement of DNA methylation alteration in ochratoxin A-induced G0/G1 phase arrest

An in vitro attempt at precision toxicology reveals the involvement of DNA methylation alteration in ochratoxin A-induced G0/G1 phase arrest

Precision toxicology evaluates the toxicity of certain substances by isolating a small group of cells with a typical phenotype of interest followed by a single cell sequencing-based analysis. In this in vitro attempt, ochratoxin A (OTA), a typical mycotoxin and food contaminant, is found to induce G...

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Bibliographic Details
Main Authors: Boyang Zhang, Liye Zhu, Yaqi Dai, Hongyu Li, Kunlun Huang, Yunbo Luo, Wentao Xu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-02-01
Series:Epigenetics
Subjects:
precision toxicology
single-cell sequencing
cell cycle arrest
dna methylation
ochratoxin a
Online Access:http://dx.doi.org/10.1080/15592294.2019.1644878

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