Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2
There is no doubt that infectious diseases present global impact on the economy, society, health, mental state, and even political aspects, causing a long-lasting dent, and the situation will surely worsen if and when the viral spread becomes out of control, as seen during the still ongoing coronavi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/14/7/1553 |
| _version_ | 1797414915199205376 |
|---|---|
| author | Nura A. Mohamed Haissam Abou-Saleh Hana A. Mohamed Mohammad A. Al-Ghouti Sergio Crovella Luisa Zupin |
| author_facet | Nura A. Mohamed Haissam Abou-Saleh Hana A. Mohamed Mohammad A. Al-Ghouti Sergio Crovella Luisa Zupin |
| author_sort | Nura A. Mohamed |
| collection | DOAJ |
| description | There is no doubt that infectious diseases present global impact on the economy, society, health, mental state, and even political aspects, causing a long-lasting dent, and the situation will surely worsen if and when the viral spread becomes out of control, as seen during the still ongoing coronavirus disease 2019 (COVID-19) pandemic. Despite the considerable achievements made in viral prevention and treatment, there are still significant challenges that can be overcome through careful understanding of the viral mechanism of action to establish common ground for innovating new preventative and treatment strategies. Viruses can be regarded as devil nanomachines, and one innovative approach to face and stop the spread of viral infections is the development of nanoparticles that can act similar to them as drug/vaccine carriers. Moreover, we can use the properties that different viruses have in designing nanoparticles that reassemble the virus conformational structures but that do not present the detrimental threats to human health that native viruses possess. This review discusses the current preventative strategies (i.e., vaccination) used in facing viral infections and the associated limitations, highlighting the importance of innovating new approaches to face viral infectious diseases and discussing the current nanoapplications in vaccine development and the challenges that still face the nanovaccine field. |
| first_indexed | 2024-03-09T05:40:53Z |
| format | Article |
| id | doaj.art-171b621000fd4b5d9243ef95d92ef0bd |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T05:40:53Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-171b621000fd4b5d9243ef95d92ef0bd2023-12-03T12:24:34ZengMDPI AGViruses1999-49152022-07-01147155310.3390/v14071553Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2Nura A. Mohamed0Haissam Abou-Saleh1Hana A. Mohamed2Mohammad A. Al-Ghouti3Sergio Crovella4Luisa Zupin5Biomedical Research Center (BRC), Qatar University, Doha P.O. Box 2713, QatarBiomedical Research Center (BRC), Qatar University, Doha P.O. Box 2713, QatarBiological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, QatarEnvironmental Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, QatarBiological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, QatarInstitute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, ItalyThere is no doubt that infectious diseases present global impact on the economy, society, health, mental state, and even political aspects, causing a long-lasting dent, and the situation will surely worsen if and when the viral spread becomes out of control, as seen during the still ongoing coronavirus disease 2019 (COVID-19) pandemic. Despite the considerable achievements made in viral prevention and treatment, there are still significant challenges that can be overcome through careful understanding of the viral mechanism of action to establish common ground for innovating new preventative and treatment strategies. Viruses can be regarded as devil nanomachines, and one innovative approach to face and stop the spread of viral infections is the development of nanoparticles that can act similar to them as drug/vaccine carriers. Moreover, we can use the properties that different viruses have in designing nanoparticles that reassemble the virus conformational structures but that do not present the detrimental threats to human health that native viruses possess. This review discusses the current preventative strategies (i.e., vaccination) used in facing viral infections and the associated limitations, highlighting the importance of innovating new approaches to face viral infectious diseases and discussing the current nanoapplications in vaccine development and the challenges that still face the nanovaccine field.https://www.mdpi.com/1999-4915/14/7/1553nanotechnologyvaccineSARS-CoV-2 |
| spellingShingle | Nura A. Mohamed Haissam Abou-Saleh Hana A. Mohamed Mohammad A. Al-Ghouti Sergio Crovella Luisa Zupin Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2 Viruses nanotechnology vaccine SARS-CoV-2 |
| title | Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2 |
| title_full | Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2 |
| title_fullStr | Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2 |
| title_full_unstemmed | Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2 |
| title_short | Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2 |
| title_sort | think like a virus toward improving nanovaccine development against sars cov 2 |
| topic | nanotechnology vaccine SARS-CoV-2 |
| url | https://www.mdpi.com/1999-4915/14/7/1553 |
| work_keys_str_mv | AT nuraamohamed thinklikeavirustowardimprovingnanovaccinedevelopmentagainstsarscov2 AT haissamabousaleh thinklikeavirustowardimprovingnanovaccinedevelopmentagainstsarscov2 AT hanaamohamed thinklikeavirustowardimprovingnanovaccinedevelopmentagainstsarscov2 AT mohammadaalghouti thinklikeavirustowardimprovingnanovaccinedevelopmentagainstsarscov2 AT sergiocrovella thinklikeavirustowardimprovingnanovaccinedevelopmentagainstsarscov2 AT luisazupin thinklikeavirustowardimprovingnanovaccinedevelopmentagainstsarscov2 |