Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties. Spermidine specifically interferes with the tumour cell cycle, resulting in the inhibit...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1164477/full |
| _version_ | 1797851350225125376 |
|---|---|
| author | Parteek Prasher Mousmee Sharma Sachin Kumar Singh Sachin Kumar Singh Monica Gulati Monica Gulati Dinesh Kumar Chellappan Rashi Rajput Rashi Rajput Gaurav Gupta Gaurav Gupta Alibek Ydyrys Marzhan Kulbayeva Ahmad Faizal Abdull Razis Ahmad Faizal Abdull Razis Babagana Modu Babagana Modu Javad Sharifi-Rad Kamal Dua Kamal Dua |
| author_facet | Parteek Prasher Mousmee Sharma Sachin Kumar Singh Sachin Kumar Singh Monica Gulati Monica Gulati Dinesh Kumar Chellappan Rashi Rajput Rashi Rajput Gaurav Gupta Gaurav Gupta Alibek Ydyrys Marzhan Kulbayeva Ahmad Faizal Abdull Razis Ahmad Faizal Abdull Razis Babagana Modu Babagana Modu Javad Sharifi-Rad Kamal Dua Kamal Dua |
| author_sort | Parteek Prasher |
| collection | DOAJ |
| description | Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties. Spermidine specifically interferes with the tumour cell cycle, resulting in the inhibition of tumor cell proliferation and suppression of tumor growth. Moreover, it also triggers autophagy by regulating key oncologic pathways. The increased intake of polyamines, such as spermidine, can suppress oncogenesis and slow the growth of tumors due to its role in anticancer immunosurveillance and regulation of polyamine metabolism. Spermidine/spermine N-1-acetyltransferase (SSAT) plays a critical role in polyamine homeostasis and serves as a diagnostic marker in human cancers. Chemically modified derivatives of spermidine hold great potential for prognostic, diagnostic, and therapeutic applications against various malignancies. This review discusses in detail the recent findings that support the anticancer mechanisms of spermidine and its molecular physiology. |
| first_indexed | 2024-04-09T19:16:28Z |
| format | Article |
| id | doaj.art-171c93dfe1f14d9a931c98cba84fcb15 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-09T19:16:28Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-171c93dfe1f14d9a931c98cba84fcb152023-04-06T04:59:53ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-04-011110.3389/fchem.2023.11644771164477Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanismsParteek Prasher0Mousmee Sharma1Sachin Kumar Singh2Sachin Kumar Singh3Monica Gulati4Monica Gulati5Dinesh Kumar Chellappan6Rashi Rajput7Rashi Rajput8Gaurav Gupta9Gaurav Gupta10Alibek Ydyrys11Marzhan Kulbayeva12Ahmad Faizal Abdull Razis13Ahmad Faizal Abdull Razis14Babagana Modu15Babagana Modu16Javad Sharifi-Rad17Kamal Dua18Kamal Dua19Department of Chemistry, University of Petroleum and Energy Studies, Dehradun, IndiaDepartment of Chemistry, Uttaranchal University, Dehradun, IndiaSchool of Pharmaceutical Science, Lovely Professional University, Phagwara, IndiaFaculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, AustraliaSchool of Pharmaceutical Science, Lovely Professional University, Phagwara, IndiaFaculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, AustraliaSchool of Pharmacy, International Medical University, Bukit Jalil, MalaysiaFaculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, AustraliaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, AustraliaSchool of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, IndiaDepartment of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaBiomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan0Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan1Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia2Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia2Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia3Department of Biochemistry, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria4Facultad de Medicina, Universidad del Azuay, Cuenca, EcuadorFaculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, AustraliaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, AustraliaSpermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties. Spermidine specifically interferes with the tumour cell cycle, resulting in the inhibition of tumor cell proliferation and suppression of tumor growth. Moreover, it also triggers autophagy by regulating key oncologic pathways. The increased intake of polyamines, such as spermidine, can suppress oncogenesis and slow the growth of tumors due to its role in anticancer immunosurveillance and regulation of polyamine metabolism. Spermidine/spermine N-1-acetyltransferase (SSAT) plays a critical role in polyamine homeostasis and serves as a diagnostic marker in human cancers. Chemically modified derivatives of spermidine hold great potential for prognostic, diagnostic, and therapeutic applications against various malignancies. This review discusses in detail the recent findings that support the anticancer mechanisms of spermidine and its molecular physiology.https://www.frontiersin.org/articles/10.3389/fchem.2023.1164477/fullspermidinepolyaminesanticancer immunosurveillancediagnostic markercell proliferationanticancer properties |
| spellingShingle | Parteek Prasher Mousmee Sharma Sachin Kumar Singh Sachin Kumar Singh Monica Gulati Monica Gulati Dinesh Kumar Chellappan Rashi Rajput Rashi Rajput Gaurav Gupta Gaurav Gupta Alibek Ydyrys Marzhan Kulbayeva Ahmad Faizal Abdull Razis Ahmad Faizal Abdull Razis Babagana Modu Babagana Modu Javad Sharifi-Rad Kamal Dua Kamal Dua Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms Frontiers in Chemistry spermidine polyamines anticancer immunosurveillance diagnostic marker cell proliferation anticancer properties |
| title | Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms |
| title_full | Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms |
| title_fullStr | Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms |
| title_full_unstemmed | Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms |
| title_short | Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms |
| title_sort | spermidine as a promising anticancer agent recent advances and newer insights on its molecular mechanisms |
| topic | spermidine polyamines anticancer immunosurveillance diagnostic marker cell proliferation anticancer properties |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1164477/full |
| work_keys_str_mv | AT parteekprasher spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT mousmeesharma spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT sachinkumarsingh spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT sachinkumarsingh spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT monicagulati spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT monicagulati spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT dineshkumarchellappan spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT rashirajput spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT rashirajput spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT gauravgupta spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT gauravgupta spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT alibekydyrys spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT marzhankulbayeva spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT ahmadfaizalabdullrazis spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT ahmadfaizalabdullrazis spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT babaganamodu spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT babaganamodu spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT javadsharifirad spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT kamaldua spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms AT kamaldua spermidineasapromisinganticanceragentrecentadvancesandnewerinsightsonitsmolecularmechanisms |