Molecular targets in GI malignancies – A pathologist's perspective
Newer molecular diagnostics and improved understanding of cancer pathogenesis have identified multiple pathways that can be potentially targeted with the use of novel therapeutics in development. These developments have ushered cancer therapeutics in newer era of personalized medicine. Same is refle...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=5;spage=43;epage=51;aulast=Pawar |
| _version_ | 1818722781323329536 |
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| author | Satyajit Pawar Atul Sharma |
| author_facet | Satyajit Pawar Atul Sharma |
| author_sort | Satyajit Pawar |
| collection | DOAJ |
| description | Newer molecular diagnostics and improved understanding of cancer pathogenesis have identified multiple pathways that can be potentially targeted with the use of novel therapeutics in development. These developments have ushered cancer therapeutics in newer era of personalized medicine. Same is reflected on current management strategies for advanced gastrointestinal malignancies. Molecular profiling for BRAF and RAS is standard for colorectal cancer while Her2 and PDL1 status is needed for planning therapy of advanced gastroesophageal cancers. Tissue agnostic markers like MSI, TMB and NTRK are making headways in therapeutic armamentarium. While newer targeted therapies against FGFR, EGFR, PI3K-AKT, DDR pathways are showing promising results in initial studies. Here we review traditional as well as upcoming molecular markers in field of GI malignancies, methods of testing and evidence for rational use in clinical practice. |
| first_indexed | 2024-12-17T21:00:05Z |
| format | Article |
| id | doaj.art-171d9dfced4441d6a20268cc176da3e6 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-17T21:00:05Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-171d9dfced4441d6a20268cc176da3e62022-12-21T21:32:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292021-01-01645435110.4103/IJPM.IJPM_1239_20Molecular targets in GI malignancies – A pathologist's perspectiveSatyajit PawarAtul SharmaNewer molecular diagnostics and improved understanding of cancer pathogenesis have identified multiple pathways that can be potentially targeted with the use of novel therapeutics in development. These developments have ushered cancer therapeutics in newer era of personalized medicine. Same is reflected on current management strategies for advanced gastrointestinal malignancies. Molecular profiling for BRAF and RAS is standard for colorectal cancer while Her2 and PDL1 status is needed for planning therapy of advanced gastroesophageal cancers. Tissue agnostic markers like MSI, TMB and NTRK are making headways in therapeutic armamentarium. While newer targeted therapies against FGFR, EGFR, PI3K-AKT, DDR pathways are showing promising results in initial studies. Here we review traditional as well as upcoming molecular markers in field of GI malignancies, methods of testing and evidence for rational use in clinical practice.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=5;spage=43;epage=51;aulast=Pawargastrointestinal cancermolecular targetsmonoclonal antibodiestargeted therapytyrosine kinase inhibitors |
| spellingShingle | Satyajit Pawar Atul Sharma Molecular targets in GI malignancies – A pathologist's perspective Indian Journal of Pathology and Microbiology gastrointestinal cancer molecular targets monoclonal antibodies targeted therapy tyrosine kinase inhibitors |
| title | Molecular targets in GI malignancies – A pathologist's perspective |
| title_full | Molecular targets in GI malignancies – A pathologist's perspective |
| title_fullStr | Molecular targets in GI malignancies – A pathologist's perspective |
| title_full_unstemmed | Molecular targets in GI malignancies – A pathologist's perspective |
| title_short | Molecular targets in GI malignancies – A pathologist's perspective |
| title_sort | molecular targets in gi malignancies a pathologist s perspective |
| topic | gastrointestinal cancer molecular targets monoclonal antibodies targeted therapy tyrosine kinase inhibitors |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=5;spage=43;epage=51;aulast=Pawar |
| work_keys_str_mv | AT satyajitpawar moleculartargetsingimalignanciesapathologistsperspective AT atulsharma moleculartargetsingimalignanciesapathologistsperspective |