Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss
Abstract Background Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association among genetics, lifestyle/environmental factors, and adherence to heal...
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BMC
2024-03-01
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Online Access: | https://doi.org/10.1186/s12916-024-03364-5 |
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author | Sang-Hyuk Jung Young Chan Lee Manu Shivakumar Jaeyoung Kim Jae-Seung Yun Woong-Yang Park Hong-Hee Won Penn Medicine Biobank Dokyoon Kim |
author_facet | Sang-Hyuk Jung Young Chan Lee Manu Shivakumar Jaeyoung Kim Jae-Seung Yun Woong-Yang Park Hong-Hee Won Penn Medicine Biobank Dokyoon Kim |
author_sort | Sang-Hyuk Jung |
collection | DOAJ |
description | Abstract Background Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association among genetics, lifestyle/environmental factors, and adherence to healthy lifestyle for risk of ARHL. We aimed to assess the association between ARHL genetic variants, lifestyle/environmental factors, and adherence to healthy lifestyle as pertains to risk of ARHL. Methods This case–control study included 376,464 European individuals aged 40 to 69 years, enrolled between 2006 and 2010 in the UK Biobank (UKBB). As a replication set, we also included a total of 26,523 individuals considered of European ancestry and 9834 individuals considered of African-American ancestry through the Penn Medicine Biobank (PMBB). The polygenic risk score (PRS) for ARHL was derived from a sensorineural hearing loss genome-wide association study from the FinnGen Consortium and categorized as low, intermediate, high, and very high. We selected lifestyle/environmental factors that have been previously studied in association with hearing loss. A composite healthy lifestyle score was determined using seven selected lifestyle behaviors and one environmental factor. Results Of the 376,464 participants, 87,066 (23.1%) cases belonged to the ARHL group, and 289,398 (76.9%) individuals comprised the control group in the UKBB. A very high PRS for ARHL had a 49% higher risk of ARHL than those with low PRS (adjusted OR, 1.49; 95% CI, 1.36–1.62; P < .001), which was replicated in the PMBB cohort. A very poor lifestyle was also associated with risk of ARHL (adjusted OR, 3.03; 95% CI, 2.75–3.35; P < .001). These risk factors showed joint effects with the risk of ARHL. Conversely, adherence to healthy lifestyle in relation to hearing mostly attenuated the risk of ARHL even in individuals with very high PRS (adjusted OR, 0.21; 95% CI, 0.09–0.52; P < .001). Conclusions Our findings of this study demonstrated a significant joint association between genetic and lifestyle factors regarding ARHL. In addition, our analysis suggested that lifestyle adherence in individuals with high genetic risk could reduce the risk of ARHL. |
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format | Article |
id | doaj.art-171e5c6d78ae457abb05035dc2b6ec89 |
institution | Directory Open Access Journal |
issn | 1741-7015 |
language | English |
last_indexed | 2024-04-24T16:17:16Z |
publishDate | 2024-03-01 |
publisher | BMC |
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spelling | doaj.art-171e5c6d78ae457abb05035dc2b6ec892024-03-31T11:22:58ZengBMCBMC Medicine1741-70152024-03-0122111410.1186/s12916-024-03364-5Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing lossSang-Hyuk Jung0Young Chan Lee1Manu Shivakumar2Jaeyoung Kim3Jae-Seung Yun4Woong-Yang Park5Hong-Hee Won6Penn Medicine Biobank7Dokyoon Kim8Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaSamsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical CenterDivision of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of KoreaSamsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of MedicineSamsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical CenterInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaAbstract Background Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association among genetics, lifestyle/environmental factors, and adherence to healthy lifestyle for risk of ARHL. We aimed to assess the association between ARHL genetic variants, lifestyle/environmental factors, and adherence to healthy lifestyle as pertains to risk of ARHL. Methods This case–control study included 376,464 European individuals aged 40 to 69 years, enrolled between 2006 and 2010 in the UK Biobank (UKBB). As a replication set, we also included a total of 26,523 individuals considered of European ancestry and 9834 individuals considered of African-American ancestry through the Penn Medicine Biobank (PMBB). The polygenic risk score (PRS) for ARHL was derived from a sensorineural hearing loss genome-wide association study from the FinnGen Consortium and categorized as low, intermediate, high, and very high. We selected lifestyle/environmental factors that have been previously studied in association with hearing loss. A composite healthy lifestyle score was determined using seven selected lifestyle behaviors and one environmental factor. Results Of the 376,464 participants, 87,066 (23.1%) cases belonged to the ARHL group, and 289,398 (76.9%) individuals comprised the control group in the UKBB. A very high PRS for ARHL had a 49% higher risk of ARHL than those with low PRS (adjusted OR, 1.49; 95% CI, 1.36–1.62; P < .001), which was replicated in the PMBB cohort. A very poor lifestyle was also associated with risk of ARHL (adjusted OR, 3.03; 95% CI, 2.75–3.35; P < .001). These risk factors showed joint effects with the risk of ARHL. Conversely, adherence to healthy lifestyle in relation to hearing mostly attenuated the risk of ARHL even in individuals with very high PRS (adjusted OR, 0.21; 95% CI, 0.09–0.52; P < .001). Conclusions Our findings of this study demonstrated a significant joint association between genetic and lifestyle factors regarding ARHL. In addition, our analysis suggested that lifestyle adherence in individuals with high genetic risk could reduce the risk of ARHL.https://doi.org/10.1186/s12916-024-03364-5Age-related hearing lossGenetic riskPolygenic risk scoreLifestyleEnvironmental factor |
spellingShingle | Sang-Hyuk Jung Young Chan Lee Manu Shivakumar Jaeyoung Kim Jae-Seung Yun Woong-Yang Park Hong-Hee Won Penn Medicine Biobank Dokyoon Kim Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss BMC Medicine Age-related hearing loss Genetic risk Polygenic risk score Lifestyle Environmental factor |
title | Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss |
title_full | Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss |
title_fullStr | Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss |
title_full_unstemmed | Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss |
title_short | Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss |
title_sort | association between genetic risk and adherence to healthy lifestyle for developing age related hearing loss |
topic | Age-related hearing loss Genetic risk Polygenic risk score Lifestyle Environmental factor |
url | https://doi.org/10.1186/s12916-024-03364-5 |
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