Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study
Abstract Introduction It remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with breast cancer. Therefore, we sought to explore the influence of demographic and pathological factors on prognosis of patients with breast cancer. Materials a...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-08-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.2352 |
| _version_ | 1797847677596073984 |
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| author | Zhen Zhai Fang Zhang Yi Zheng Linghui Zhou Tian Tian Shuai Lin Yujiao Deng Peng Xu Qian Hao Na Li Pengtao Yang Hongtao Li Zhijun Dai |
| author_facet | Zhen Zhai Fang Zhang Yi Zheng Linghui Zhou Tian Tian Shuai Lin Yujiao Deng Peng Xu Qian Hao Na Li Pengtao Yang Hongtao Li Zhijun Dai |
| author_sort | Zhen Zhai |
| collection | DOAJ |
| description | Abstract Introduction It remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with breast cancer. Therefore, we sought to explore the influence of demographic and pathological factors on prognosis of patients with breast cancer. Materials and methods We selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, and End Results (SEER) cancer registry program. We assessed the effect of marital status on overall survival (OS) and BCSS using Kaplan‐Meier curve and multivariate Cox proportional hazards regression. Results Compared with divorced/separated/widowed (DSW) patients, the married (AHR 0.7483, 95% CI: 0.729‐0.7682, P < 0.001) and single patients had better BCSS (AHR 0.9096, 95% CI: 0.8796‐0.9406, P < 0.001). Married patients kept better prognosis among all age subgroups, while the better BCSS of single patients occurred only in groups older than 35 years. As for race and hormone receptor status (HRs), the better BCSS of single patients was only observed in white race (AHR 0.881, 95% CI: 0.8457‐0.9177, P < 0.001) and patients with ER+/PR + status (AHR 0.8844, 95% CI: 0.8393‐0.932, P < 0.001). Conclusion Our findings demonstrated that married and single patients with breast cancer had better prognosis than their DSW counterparts. Age, race, and HRs could affect the correlation between marital status and BCSS. |
| first_indexed | 2024-04-09T18:15:18Z |
| format | Article |
| id | doaj.art-171eb7d220fd44cc8f9bdb0c0dd8c192 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-09T18:15:18Z |
| publishDate | 2019-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-171eb7d220fd44cc8f9bdb0c0dd8c1922023-04-13T04:36:19ZengWileyCancer Medicine2045-76342019-08-018104906491710.1002/cam4.2352Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based StudyZhen Zhai0Fang Zhang1Yi Zheng2Linghui Zhou3Tian Tian4Shuai Lin5Yujiao Deng6Peng Xu7Qian Hao8Na Li9Pengtao Yang10Hongtao Li11Zhijun Dai12Department of Breast Surgery, The First Affiliated Hospital College of MedicineZhejiang University Hangzhou ChinaThe Second Department of Oncology The Central Hospital of Enshi Tujia and Miao Autonomous Prefacture Enshi ChinaDepartment of Breast Surgery, The First Affiliated Hospital College of MedicineZhejiang University Hangzhou ChinaDepartment of Breast Surgery, The First Affiliated Hospital College of MedicineZhejiang University Hangzhou ChinaDepartment of Breast Surgery, The First Affiliated Hospital College of MedicineZhejiang University Hangzhou ChinaDepartment of Oncology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Oncology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Breast Surgery, The First Affiliated Hospital College of MedicineZhejiang University Hangzhou ChinaDepartment of Oncology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Oncology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Oncology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Breast Head and Neck surgery The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Tumor Hospital) Urumqi ChinaDepartment of Breast Surgery, The First Affiliated Hospital College of MedicineZhejiang University Hangzhou ChinaAbstract Introduction It remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with breast cancer. Therefore, we sought to explore the influence of demographic and pathological factors on prognosis of patients with breast cancer. Materials and methods We selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, and End Results (SEER) cancer registry program. We assessed the effect of marital status on overall survival (OS) and BCSS using Kaplan‐Meier curve and multivariate Cox proportional hazards regression. Results Compared with divorced/separated/widowed (DSW) patients, the married (AHR 0.7483, 95% CI: 0.729‐0.7682, P < 0.001) and single patients had better BCSS (AHR 0.9096, 95% CI: 0.8796‐0.9406, P < 0.001). Married patients kept better prognosis among all age subgroups, while the better BCSS of single patients occurred only in groups older than 35 years. As for race and hormone receptor status (HRs), the better BCSS of single patients was only observed in white race (AHR 0.881, 95% CI: 0.8457‐0.9177, P < 0.001) and patients with ER+/PR + status (AHR 0.8844, 95% CI: 0.8393‐0.932, P < 0.001). Conclusion Our findings demonstrated that married and single patients with breast cancer had better prognosis than their DSW counterparts. Age, race, and HRs could affect the correlation between marital status and BCSS.https://doi.org/10.1002/cam4.2352breast cancermarital statusprognosisSEER |
| spellingShingle | Zhen Zhai Fang Zhang Yi Zheng Linghui Zhou Tian Tian Shuai Lin Yujiao Deng Peng Xu Qian Hao Na Li Pengtao Yang Hongtao Li Zhijun Dai Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study Cancer Medicine breast cancer marital status prognosis SEER |
| title | Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study |
| title_full | Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study |
| title_fullStr | Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study |
| title_full_unstemmed | Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study |
| title_short | Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study |
| title_sort | effects of marital status on breast cancer survival by age race and hormone receptor status a population based study |
| topic | breast cancer marital status prognosis SEER |
| url | https://doi.org/10.1002/cam4.2352 |
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