Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study
Introduction: The current standard of treatment for locally advanced cancer of cervix is cisplatin based concurrent chemo radiation therapy followed by brachytherapy. Concurrent chemo radiotherapy causes acute hematological toxicities, which in turn leads to prolongation of therapy. Objective: The...
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| Format: | Article |
| Language: | English |
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West Asia Organization for Cancer Prevention
2022-11-01
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| Series: | Asian Pacific Journal of Cancer Care |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcc/article/view/938 |
| _version_ | 1797342222507573248 |
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| author | Chiranjiv Baruah Trishan Paul Biswajit Sarma Kankan Jyoti Deka Partha Pratim Patowory |
| author_facet | Chiranjiv Baruah Trishan Paul Biswajit Sarma Kankan Jyoti Deka Partha Pratim Patowory |
| author_sort | Chiranjiv Baruah |
| collection | DOAJ |
| description | Introduction: The current standard of treatment for locally advanced cancer of cervix is cisplatin based concurrent chemo radiation therapy followed by brachytherapy. Concurrent chemo radiotherapy causes acute hematological toxicities, which in turn leads to prolongation of therapy.
Objective: The main purpose of our study, was to analyze the acute hematological toxicity in cervical cancer patients undergoing radiation or chemo radiation therapy.
Materials and Methods: This is a hospital based observational study done at department of Radiation Oncology, Assam medical college and hospital. All the biopsy proven cervical cancer patients attending the department, within the study period from September 2020 to May 2021 are included in the study.
Results: Out of 26 patients in the study sample, grade 1 hematologicaltoxicity is seen in 2 patients (7.5%), grade 2 hematological toxicity seen in 20 patients (77%), grade 3 hematological toxicities in 4 patients (15.5%) and none of the patients developed grade 4 nor grade 5 hematological toxicity or any other life threatening complications.
Conclusion: Hematological toxicity is more common with conventional external beam therapy in locally advanced carcinoma cervix patients. Compared to conventional external beam radiotherapy and 3DCRT, patients undergoing treatment with IMRT experiences significantly less acute grade ≥2 hematological toxicities. |
| first_indexed | 2024-03-08T10:30:10Z |
| format | Article |
| id | doaj.art-171fd29ec96f43128a2352aff488498f |
| institution | Directory Open Access Journal |
| issn | 2588-3682 |
| language | English |
| last_indexed | 2024-03-08T10:30:10Z |
| publishDate | 2022-11-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Care |
| spelling | doaj.art-171fd29ec96f43128a2352aff488498f2024-01-27T05:51:48ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Care2588-36822022-11-017465165510.31557/apjcc.2022.7.4.651-655938Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective StudyChiranjiv Baruah0Trishan Paul1Biswajit Sarma2Kankan Jyoti Deka3Partha Pratim PatoworyRadiation Oncology, Assam Medical College, India.Radiation Oncology, Assam Medical College, India.Radiation Oncology, Assam Medical College, India.Radiation Oncology, Assam Medical College, India.Introduction: The current standard of treatment for locally advanced cancer of cervix is cisplatin based concurrent chemo radiation therapy followed by brachytherapy. Concurrent chemo radiotherapy causes acute hematological toxicities, which in turn leads to prolongation of therapy. Objective: The main purpose of our study, was to analyze the acute hematological toxicity in cervical cancer patients undergoing radiation or chemo radiation therapy. Materials and Methods: This is a hospital based observational study done at department of Radiation Oncology, Assam medical college and hospital. All the biopsy proven cervical cancer patients attending the department, within the study period from September 2020 to May 2021 are included in the study. Results: Out of 26 patients in the study sample, grade 1 hematologicaltoxicity is seen in 2 patients (7.5%), grade 2 hematological toxicity seen in 20 patients (77%), grade 3 hematological toxicities in 4 patients (15.5%) and none of the patients developed grade 4 nor grade 5 hematological toxicity or any other life threatening complications. Conclusion: Hematological toxicity is more common with conventional external beam therapy in locally advanced carcinoma cervix patients. Compared to conventional external beam radiotherapy and 3DCRT, patients undergoing treatment with IMRT experiences significantly less acute grade ≥2 hematological toxicities.http://www.waocp.com/journal/index.php/apjcc/article/view/938radiation therapyhematological toxicitycarcinoma cervix |
| spellingShingle | Chiranjiv Baruah Trishan Paul Biswajit Sarma Kankan Jyoti Deka Partha Pratim Patowory Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study Asian Pacific Journal of Cancer Care radiation therapy hematological toxicity carcinoma cervix |
| title | Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study |
| title_full | Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study |
| title_fullStr | Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study |
| title_full_unstemmed | Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study |
| title_short | Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study |
| title_sort | hematological toxicity in carcinoma cervix patients undergoing concurrent chemo radiation therapy or radiation therapy alone in a tertiary hospital of north east india a prospective study |
| topic | radiation therapy hematological toxicity carcinoma cervix |
| url | http://www.waocp.com/journal/index.php/apjcc/article/view/938 |
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