Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection?
This study was conducted to evaluate the effect of feed supplementation with a medicinal herbs mixture (Hmix) and organic zinc (Zn), alone or in combination, on the antioxidant responses and mineral status of lambs infected with the gastrointestinal nematode parasite <i>Haemonchus contortus<...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/12/1172 |
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| author | Klaudia Čobanová Zora Váradyová Ľubomíra Grešáková Katarína Kucková Dominika Mravčáková Marián Várady |
| author_facet | Klaudia Čobanová Zora Váradyová Ľubomíra Grešáková Katarína Kucková Dominika Mravčáková Marián Várady |
| author_sort | Klaudia Čobanová |
| collection | DOAJ |
| description | This study was conducted to evaluate the effect of feed supplementation with a medicinal herbs mixture (Hmix) and organic zinc (Zn), alone or in combination, on the antioxidant responses and mineral status of lambs infected with the gastrointestinal nematode parasite <i>Haemonchus contortus</i>. A total of 24 experimentally infected lambs were randomly allocated to 1 of 4 dietary treatments (<i>n</i> = 6). The diets included an unsupplemented control diet (CON) and the CON further supplemented with Hmix, Zn, or both Hmix + Zn. Antioxidant enzymes activities, lipid peroxidation, total antioxidant capacity (TAC) and microelement (Zn, Cu, Fe, Mn) concentrations were analyzed in serum, liver, kidney, and intestinal mucosa. Zinc treatment elevated the superoxide dismutase activities in the duodenal mucosa and ileal TAC. Intake of Hmix resulted in higher kidney and ileal catalase activity and also influenced the TAC of the liver and intestinal mucosa. The inclusion of Hmix or Zn alone into the diet increased glutathione peroxidase activity in the blood, liver and duodenal mucosa. Tissue mineral uptake was not affected by herbal supplementation. Organic Zn intake increased the serum and liver Zn levels and influenced the Cu concentration in duodenal mucosa. Dietary supplementation with Hmix and/or Zn might promote the antioxidant status of lambs infected with <i>Haemonchus</i> spp. |
| first_indexed | 2024-03-10T14:35:37Z |
| format | Article |
| id | doaj.art-17205f9062b14d3ba635cb6bbba61d25 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T14:35:37Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-17205f9062b14d3ba635cb6bbba61d252023-11-20T22:11:55ZengMDPI AGAntioxidants2076-39212020-11-01912117210.3390/antiox9121172Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection?Klaudia Čobanová0Zora Váradyová1Ľubomíra Grešáková2Katarína Kucková3Dominika Mravčáková4Marián Várady5Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal Physiology, 040 01 Košice, SlovakiaCentre of Biosciences of the Slovak Academy of Sciences, Institute of Animal Physiology, 040 01 Košice, SlovakiaCentre of Biosciences of the Slovak Academy of Sciences, Institute of Animal Physiology, 040 01 Košice, SlovakiaCentre of Biosciences of the Slovak Academy of Sciences, Institute of Animal Physiology, 040 01 Košice, SlovakiaCentre of Biosciences of the Slovak Academy of Sciences, Institute of Animal Physiology, 040 01 Košice, SlovakiaInstitute of Parasitology, Slovak Academy of Sciences, 040 01 Košice, SlovakiaThis study was conducted to evaluate the effect of feed supplementation with a medicinal herbs mixture (Hmix) and organic zinc (Zn), alone or in combination, on the antioxidant responses and mineral status of lambs infected with the gastrointestinal nematode parasite <i>Haemonchus contortus</i>. A total of 24 experimentally infected lambs were randomly allocated to 1 of 4 dietary treatments (<i>n</i> = 6). The diets included an unsupplemented control diet (CON) and the CON further supplemented with Hmix, Zn, or both Hmix + Zn. Antioxidant enzymes activities, lipid peroxidation, total antioxidant capacity (TAC) and microelement (Zn, Cu, Fe, Mn) concentrations were analyzed in serum, liver, kidney, and intestinal mucosa. Zinc treatment elevated the superoxide dismutase activities in the duodenal mucosa and ileal TAC. Intake of Hmix resulted in higher kidney and ileal catalase activity and also influenced the TAC of the liver and intestinal mucosa. The inclusion of Hmix or Zn alone into the diet increased glutathione peroxidase activity in the blood, liver and duodenal mucosa. Tissue mineral uptake was not affected by herbal supplementation. Organic Zn intake increased the serum and liver Zn levels and influenced the Cu concentration in duodenal mucosa. Dietary supplementation with Hmix and/or Zn might promote the antioxidant status of lambs infected with <i>Haemonchus</i> spp.https://www.mdpi.com/2076-3921/9/12/1172herbal treatmentorganic zinclamb<i>Haemonchus contortus</i>antioxidant enzymeslipid peroxidation |
| spellingShingle | Klaudia Čobanová Zora Váradyová Ľubomíra Grešáková Katarína Kucková Dominika Mravčáková Marián Várady Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection? Antioxidants herbal treatment organic zinc lamb <i>Haemonchus contortus</i> antioxidant enzymes lipid peroxidation |
| title | Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection? |
| title_full | Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection? |
| title_fullStr | Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection? |
| title_full_unstemmed | Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection? |
| title_short | Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection? |
| title_sort | does herbal and or zinc dietary supplementation improve the antioxidant and mineral status of lambs with parasite infection |
| topic | herbal treatment organic zinc lamb <i>Haemonchus contortus</i> antioxidant enzymes lipid peroxidation |
| url | https://www.mdpi.com/2076-3921/9/12/1172 |
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