3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity
<p>In bone tissue engineering, scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration, attracting increasingly interests in clinical practice. In this study, strontium-incorporated β-tricalcium phosphate (β-TCP), named Sr-TC...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2023-09-01
|
| Series: | Journal of Advanced Ceramics |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/JAC.2023.9220787 |
| _version_ | 1827796131821649920 |
|---|---|
| author | Yanbo Shan Yang Bai Shuo Yang Qing Zhou Gang Wang Biao Zhu Yiwen Zhou Wencan Fang Ning Wen Rujie He Lisheng Zhao |
| author_facet | Yanbo Shan Yang Bai Shuo Yang Qing Zhou Gang Wang Biao Zhu Yiwen Zhou Wencan Fang Ning Wen Rujie He Lisheng Zhao |
| author_sort | Yanbo Shan |
| collection | DOAJ |
| description | <p>In bone tissue engineering, scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration, attracting increasingly interests in clinical practice. In this study, strontium-incorporated β-tricalcium phosphate (β-TCP), named Sr-TCP, bioceramic triply periodic minimal surface (TPMS) structured scaffolds were successfully fabricated by digital light processing (DLP)-based 3D printing technique, achieving high porosity, enhanced strength, and excellent bioactivity. The Sr-TCP scaffolds were first characterized by element distribution, macrostructure and microstructure, and mechanical properties. Notably, the compressive strength of the scaffolds reached 1.44 MPa with porosity of 80%, bringing a great mechanical breakthrough to porous scaffolds. Furthermore, the Sr-TCP scaffolds also facilitated osteogenic differentiation of mouse osteoblastic cell line (MC3T3-E1) cells in both gene and protein aspects, verified by alkaline phosphatase (ALP) activity and polymerase chain reaction (PCR) assays. Overall, the 3D-printed Sr-TCP bioceramic TPMS structured scaffolds obtained high porosity, boosted strength, and superior bioactivity at the same time, serving as a promising approach for bone regeneration.</p> |
| first_indexed | 2024-03-11T19:02:05Z |
| format | Article |
| id | doaj.art-1720f668bd374239a24c08e718a1e211 |
| institution | Directory Open Access Journal |
| issn | 2226-4108 2227-8508 |
| language | English |
| last_indexed | 2024-03-11T19:02:05Z |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Journal of Advanced Ceramics |
| spelling | doaj.art-1720f668bd374239a24c08e718a1e2112023-10-10T11:17:44ZengTsinghua University PressJournal of Advanced Ceramics2226-41082227-85082023-09-011291671168410.26599/JAC.2023.92207873D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivityYanbo Shan0Yang Bai1Shuo Yang2Qing Zhou3Gang Wang4Biao Zhu5Yiwen Zhou6Wencan Fang7Ning Wen8Rujie He9Lisheng Zhao10Chinese PLA Medical School, Beijing 100853, ChinaInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, ChinaInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, ChinaInstitute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, ChinaChinese PLA Medical School, Beijing 100853, ChinaInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, ChinaChinese PLA Medical School, Beijing 100853, ChinaChinese PLA Medical School, Beijing 100853, ChinaInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, ChinaInstitute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, ChinaInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China<p>In bone tissue engineering, scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration, attracting increasingly interests in clinical practice. In this study, strontium-incorporated β-tricalcium phosphate (β-TCP), named Sr-TCP, bioceramic triply periodic minimal surface (TPMS) structured scaffolds were successfully fabricated by digital light processing (DLP)-based 3D printing technique, achieving high porosity, enhanced strength, and excellent bioactivity. The Sr-TCP scaffolds were first characterized by element distribution, macrostructure and microstructure, and mechanical properties. Notably, the compressive strength of the scaffolds reached 1.44 MPa with porosity of 80%, bringing a great mechanical breakthrough to porous scaffolds. Furthermore, the Sr-TCP scaffolds also facilitated osteogenic differentiation of mouse osteoblastic cell line (MC3T3-E1) cells in both gene and protein aspects, verified by alkaline phosphatase (ALP) activity and polymerase chain reaction (PCR) assays. Overall, the 3D-printed Sr-TCP bioceramic TPMS structured scaffolds obtained high porosity, boosted strength, and superior bioactivity at the same time, serving as a promising approach for bone regeneration.</p>https://www.sciopen.com/article/10.26599/JAC.2023.9220787strontiumβ-tricalcium phosphate (β-tcp)digital light processing (dlp)3d printingtriply periodic minimal surface (tpms)bone scaffold |
| spellingShingle | Yanbo Shan Yang Bai Shuo Yang Qing Zhou Gang Wang Biao Zhu Yiwen Zhou Wencan Fang Ning Wen Rujie He Lisheng Zhao 3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity Journal of Advanced Ceramics strontium β-tricalcium phosphate (β-tcp) digital light processing (dlp) 3d printing triply periodic minimal surface (tpms) bone scaffold |
| title | 3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity |
| title_full | 3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity |
| title_fullStr | 3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity |
| title_full_unstemmed | 3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity |
| title_short | 3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity |
| title_sort | 3d printed strontium incorporated β tcp bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity enhanced strength and excellent bioactivity |
| topic | strontium β-tricalcium phosphate (β-tcp) digital light processing (dlp) 3d printing triply periodic minimal surface (tpms) bone scaffold |
| url | https://www.sciopen.com/article/10.26599/JAC.2023.9220787 |
| work_keys_str_mv | AT yanboshan 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT yangbai 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT shuoyang 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT qingzhou 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT gangwang 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT biaozhu 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT yiwenzhou 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT wencanfang 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT ningwen 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT rujiehe 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity AT lishengzhao 3dprintedstrontiumincorporatedbtcpbioceramictriplyperiodicminimalsurfacescaffoldswithsimultaneoushighporosityenhancedstrengthandexcellentbioactivity |