Infections in Burn Patients: A Retrospective View over Seven Years
<i>Background</i><i>and objectives</i><i>:</i> Burn patients represent a challenging cohort because the injuries entail a vulnerability to colonisation by microorganisms. The ensuing infections can lead to serious complications and, in many cases, to the death of...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/8/1066 |
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| author | Savas Tsolakidis David Lysander Freytag Elisabeth Dovern Ziyad Alharbi Bong-Sung Kim Khosrow Siamak Houschyar Georg Reumuth Benedikt Schäfer Hans-Oliver Rennekampff Norbert Pallua Gerrit Grieb |
| author_facet | Savas Tsolakidis David Lysander Freytag Elisabeth Dovern Ziyad Alharbi Bong-Sung Kim Khosrow Siamak Houschyar Georg Reumuth Benedikt Schäfer Hans-Oliver Rennekampff Norbert Pallua Gerrit Grieb |
| author_sort | Savas Tsolakidis |
| collection | DOAJ |
| description | <i>Background</i><i>and objectives</i><i>:</i> Burn patients represent a challenging cohort because the injuries entail a vulnerability to colonisation by microorganisms. The ensuing infections can lead to serious complications and, in many cases, to the death of the burn patient. Surgical intervention and wound dressings, as well as antibiotic treatment, are crucial for optimising the treatment of the patient. <i>Material</i><i>and Methods:</i> In this retrospective analysis, we analysed the treatment course, antibiotic therapy, and general complications of 252 burn patients with second- or third-degree burns over a time span of 7 years. <i>Results:</i> Patients who developed infections tended to have, on average, a higher total body surface area (TBSA), higher abbreviated burn severity index (ABSI) scores, and longer hospital stays. Patients who were admitted to the burn unit after 2006 had significantly shorter stays in the burn unit. TBSA and ABSI scores were lower in the patient cohort admitted after 2006. Patients exhibiting a TBSA greater than 30% had significantly longer hospital stays and antibiotic treatment periods. TBSA and ABSI scores were significantly higher in patients who died. The results of binary logistic regression indicate that a higher ABSI score increases the odds ratio of developing an infection. Bacteria number had no significant effect on the odds of patient death but positively influenced the odds ratio of developing an infection. TBSA was negatively associated with the risk of developing an infection and was an insignificant predictor of mortality. <i>Conclusions:</i> To gauge the optimal treatment for a burn patient, it is crucial for practitioners to correctly select, dose, and time antibiotics for the patient. Monitoring bacterial colonisation is vital to nip rising infection in the bud and ensure the correct antibiotic selection. This will help prevent the development of multi-resistant bacteria. |
| first_indexed | 2024-03-09T12:58:29Z |
| format | Article |
| id | doaj.art-172124b519cf4f1eb3ed9f95df8750c7 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T12:58:29Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-172124b519cf4f1eb3ed9f95df8750c72023-11-30T21:56:29ZengMDPI AGMedicina1010-660X1648-91442022-08-01588106610.3390/medicina58081066Infections in Burn Patients: A Retrospective View over Seven YearsSavas Tsolakidis0David Lysander Freytag1Elisabeth Dovern2Ziyad Alharbi3Bong-Sung Kim4Khosrow Siamak Houschyar5Georg Reumuth6Benedikt Schäfer7Hans-Oliver Rennekampff8Norbert Pallua9Gerrit Grieb10Department of Plastic Surgery and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Plastic Surgery and Hand Surgery, Gemeinschaftskrankenhaus Havelhoehe, Kladower Damm 221, 14089 Berlin, GermanyDepartment of Plastic Surgery and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Plastic Surgery and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Plastic Surgery and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Plastic Surgery and Hand Surgery, Gemeinschaftskrankenhaus Havelhoehe, Kladower Damm 221, 14089 Berlin, GermanyDepartment of Plastic Surgery and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Plastic Surgery and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Plastic Surgery and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Plastic Surgery and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany<i>Background</i><i>and objectives</i><i>:</i> Burn patients represent a challenging cohort because the injuries entail a vulnerability to colonisation by microorganisms. The ensuing infections can lead to serious complications and, in many cases, to the death of the burn patient. Surgical intervention and wound dressings, as well as antibiotic treatment, are crucial for optimising the treatment of the patient. <i>Material</i><i>and Methods:</i> In this retrospective analysis, we analysed the treatment course, antibiotic therapy, and general complications of 252 burn patients with second- or third-degree burns over a time span of 7 years. <i>Results:</i> Patients who developed infections tended to have, on average, a higher total body surface area (TBSA), higher abbreviated burn severity index (ABSI) scores, and longer hospital stays. Patients who were admitted to the burn unit after 2006 had significantly shorter stays in the burn unit. TBSA and ABSI scores were lower in the patient cohort admitted after 2006. Patients exhibiting a TBSA greater than 30% had significantly longer hospital stays and antibiotic treatment periods. TBSA and ABSI scores were significantly higher in patients who died. The results of binary logistic regression indicate that a higher ABSI score increases the odds ratio of developing an infection. Bacteria number had no significant effect on the odds of patient death but positively influenced the odds ratio of developing an infection. TBSA was negatively associated with the risk of developing an infection and was an insignificant predictor of mortality. <i>Conclusions:</i> To gauge the optimal treatment for a burn patient, it is crucial for practitioners to correctly select, dose, and time antibiotics for the patient. Monitoring bacterial colonisation is vital to nip rising infection in the bud and ensure the correct antibiotic selection. This will help prevent the development of multi-resistant bacteria.https://www.mdpi.com/1648-9144/58/8/1066burninfectionantibiotics |
| spellingShingle | Savas Tsolakidis David Lysander Freytag Elisabeth Dovern Ziyad Alharbi Bong-Sung Kim Khosrow Siamak Houschyar Georg Reumuth Benedikt Schäfer Hans-Oliver Rennekampff Norbert Pallua Gerrit Grieb Infections in Burn Patients: A Retrospective View over Seven Years Medicina burn infection antibiotics |
| title | Infections in Burn Patients: A Retrospective View over Seven Years |
| title_full | Infections in Burn Patients: A Retrospective View over Seven Years |
| title_fullStr | Infections in Burn Patients: A Retrospective View over Seven Years |
| title_full_unstemmed | Infections in Burn Patients: A Retrospective View over Seven Years |
| title_short | Infections in Burn Patients: A Retrospective View over Seven Years |
| title_sort | infections in burn patients a retrospective view over seven years |
| topic | burn infection antibiotics |
| url | https://www.mdpi.com/1648-9144/58/8/1066 |
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