The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis
Abstract This meta-analysis aimed to assess the efficacy and safety of fluconazole for the prevention of invasive fungal infections (IFI) in very low birth weight infants (VLBWI) and to provide a basis for the clinical use. A detailed search of Pubmed, Embase, Cochrane Library and other databases wa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13052-023-01460-5 |
| _version_ | 1797836329102344192 |
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| author | Jinghong Xie Jiayue Zeng Shouyan Zheng |
| author_facet | Jinghong Xie Jiayue Zeng Shouyan Zheng |
| author_sort | Jinghong Xie |
| collection | DOAJ |
| description | Abstract This meta-analysis aimed to assess the efficacy and safety of fluconazole for the prevention of invasive fungal infections (IFI) in very low birth weight infants (VLBWI) and to provide a basis for the clinical use. A detailed search of Pubmed, Embase, Cochrane Library and other databases was performed to carefully screen eligible randomized controlled clinical studies to assess the safety and efficacy of fluconazole in very low birth weight infants in terms of the incidence of invasive fungal infections, fungal colonization rate, and mortality. Our research indicated that the application of fluconazole did not result in intolerable adverse reactions in patients. Fluconazole is effective in preventing invasive fungal infections in very low birth weight infants without serious adverse effects. The dose and frequency of fluconazole in very low birth weight infants still needs to be evaluated in consequent studies. |
| first_indexed | 2024-04-09T15:07:03Z |
| format | Article |
| id | doaj.art-172164cfe18b4b55977e3a8992d32f0b |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-04-09T15:07:03Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-172164cfe18b4b55977e3a8992d32f0b2023-04-30T11:22:43ZengBMCItalian Journal of Pediatrics1824-72882023-04-014911810.1186/s13052-023-01460-5The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysisJinghong Xie0Jiayue Zeng1Shouyan Zheng2Department of Pediatrics, Southwest Hospital of Army Medical UniversityDepartment of Gastroenterology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Pediatrics, Southwest Hospital of Army Medical UniversityAbstract This meta-analysis aimed to assess the efficacy and safety of fluconazole for the prevention of invasive fungal infections (IFI) in very low birth weight infants (VLBWI) and to provide a basis for the clinical use. A detailed search of Pubmed, Embase, Cochrane Library and other databases was performed to carefully screen eligible randomized controlled clinical studies to assess the safety and efficacy of fluconazole in very low birth weight infants in terms of the incidence of invasive fungal infections, fungal colonization rate, and mortality. Our research indicated that the application of fluconazole did not result in intolerable adverse reactions in patients. Fluconazole is effective in preventing invasive fungal infections in very low birth weight infants without serious adverse effects. The dose and frequency of fluconazole in very low birth weight infants still needs to be evaluated in consequent studies.https://doi.org/10.1186/s13052-023-01460-5FluconazoleFungal infectionVery low birth weight infantsEfficacyAdverse reaction |
| spellingShingle | Jinghong Xie Jiayue Zeng Shouyan Zheng The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis Italian Journal of Pediatrics Fluconazole Fungal infection Very low birth weight infants Efficacy Adverse reaction |
| title | The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis |
| title_full | The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis |
| title_fullStr | The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis |
| title_full_unstemmed | The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis |
| title_short | The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis |
| title_sort | efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants a systematic review and meta analysis |
| topic | Fluconazole Fungal infection Very low birth weight infants Efficacy Adverse reaction |
| url | https://doi.org/10.1186/s13052-023-01460-5 |
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