Early experience with the use of Cissus quadrangularis and Dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritis
Background: Bone marrow edema (BME) refers to the accumulation of excess fluid in the bone marrow, often indicative of injury or inflammation. Some studies suggest that incorporating plant-based therapies, rich in anti-inflammatory compounds and nutrients, may contribute to alleviating BME and promo...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2024-04-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/61272 |
| _version_ | 1797227073960411136 |
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| author | Sanjay Bhalchandra Londhe Ravi Vinod Shah Clavio DeSouza Vikram Londhe Dolly Singh |
| author_facet | Sanjay Bhalchandra Londhe Ravi Vinod Shah Clavio DeSouza Vikram Londhe Dolly Singh |
| author_sort | Sanjay Bhalchandra Londhe |
| collection | DOAJ |
| description | Background: Bone marrow edema (BME) refers to the accumulation of excess fluid in the bone marrow, often indicative of injury or inflammation. Some studies suggest that incorporating plant-based therapies, rich in anti-inflammatory compounds and nutrients, may contribute to alleviating BME and promoting overall bone health.
Aims and Objective: The study aims to evaluate the effect of Cissus quadrangularis and Dalbergia sissoo therapy on BME and knee pain associated with degenerative medial compartment knee osteoarthritis (OA).
Materials and Methods: This retrospective study examined seven individuals with medial tibial condyle BME associated with medial compartment OA. These patients were treated with initial 10 days of non-steroidal anti-inflammatory drugs along with once-a-day tablet containing C. quadrangularis (500 mg) and D. sissoo (400 mg). Visual analogue scores (VAS) and Oxford knee score (OKS) were noted at the beginning of the therapy and at 12 weeks of completion of therapy. Before treatment, BME (percentage of the medial tibial condyle) and presence/absence of subtle subchondral fracture were diagnosed with T2-weighted magnetic resonance imaging (MRI) images, and subsequently, its resolution was confirmed with a repeat MRI scan at 12 weeks.
Results: At the end of 12 weeks of therapy, there was a statistically significant improvement in the mean VAS score (baseline 8.14±0.90 improved to 2.00±0.58 at 12 weeks, [P<0.0001]), OKS (baseline 25.71±1.80 improved to 36.57±1.51 at 12 weeks, [P=0.0001]), and there was statistically significant decrease in mean BME (baseline 37.86±10.35% decreased to 14.29±4.50% at the end of 12 weeks, [P=0.0001]).
Conclusion: Our early experience shows that the combination therapy of C. quadrangularis + D. sissoo is effective in relief of pain, improvement in knee function, and resolution of BME associated with medial compartment knee OA. This combination is safe, effective, and well-tolerated by patients’ population. |
| first_indexed | 2024-04-24T14:35:01Z |
| format | Article |
| id | doaj.art-1721e39997c14d748fcd51824a7cae6f |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-24T14:35:01Z |
| publishDate | 2024-04-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-1721e39997c14d748fcd51824a7cae6f2024-04-03T00:42:47ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762024-04-01154192197https://doi.org/10.3126/ajms.v15i4.61272Early experience with the use of Cissus quadrangularis and Dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritisSanjay Bhalchandra Londhe 0https://orcid.org/0000-0002-2059-9765Ravi Vinod Shah 1https://orcid.org/0000-0002-7923-9596Clavio DeSouza 2https://orcid.org/0000-0001-7177-7624Vikram Londhe 3Dolly Singh4Orthopeadic Surgeon, Department of Orthopaedics, Criticare Asia Hospital, Mumbai, Maharashtra, India Orthopeadic Surgeon, Department of Orthopaedics, Criticare Asia Hospital, Mumbai, Maharashtra, India Consultant Trauma, Arthroplasty and Sports Medicine, Department of Orthopaedics, Holy Spirit Hospital, Mumbai, Maharashtra, India Associate Professor, Department of Medicine and in Charge of Rheumatology, HBT Medical College and Dr. R. N Cooper Hospital, Mumbai, Maharashtra, IndiaResearch Associate, Department of Clinical Research, Meril Life Sciences, Vapi, Gujarat, India https://orcid.org/0009-0008-7604-4444Background: Bone marrow edema (BME) refers to the accumulation of excess fluid in the bone marrow, often indicative of injury or inflammation. Some studies suggest that incorporating plant-based therapies, rich in anti-inflammatory compounds and nutrients, may contribute to alleviating BME and promoting overall bone health. Aims and Objective: The study aims to evaluate the effect of Cissus quadrangularis and Dalbergia sissoo therapy on BME and knee pain associated with degenerative medial compartment knee osteoarthritis (OA). Materials and Methods: This retrospective study examined seven individuals with medial tibial condyle BME associated with medial compartment OA. These patients were treated with initial 10 days of non-steroidal anti-inflammatory drugs along with once-a-day tablet containing C. quadrangularis (500 mg) and D. sissoo (400 mg). Visual analogue scores (VAS) and Oxford knee score (OKS) were noted at the beginning of the therapy and at 12 weeks of completion of therapy. Before treatment, BME (percentage of the medial tibial condyle) and presence/absence of subtle subchondral fracture were diagnosed with T2-weighted magnetic resonance imaging (MRI) images, and subsequently, its resolution was confirmed with a repeat MRI scan at 12 weeks. Results: At the end of 12 weeks of therapy, there was a statistically significant improvement in the mean VAS score (baseline 8.14±0.90 improved to 2.00±0.58 at 12 weeks, [P<0.0001]), OKS (baseline 25.71±1.80 improved to 36.57±1.51 at 12 weeks, [P=0.0001]), and there was statistically significant decrease in mean BME (baseline 37.86±10.35% decreased to 14.29±4.50% at the end of 12 weeks, [P=0.0001]). Conclusion: Our early experience shows that the combination therapy of C. quadrangularis + D. sissoo is effective in relief of pain, improvement in knee function, and resolution of BME associated with medial compartment knee OA. This combination is safe, effective, and well-tolerated by patients’ population.https://www.nepjol.info/index.php/AJMS/article/view/61272bone marrow edema; cissus quadrangularis; dalbergia sissoo; osteoarthritis |
| spellingShingle | Sanjay Bhalchandra Londhe Ravi Vinod Shah Clavio DeSouza Vikram Londhe Dolly Singh Early experience with the use of Cissus quadrangularis and Dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritis Asian Journal of Medical Sciences bone marrow edema; cissus quadrangularis; dalbergia sissoo; osteoarthritis |
| title | Early experience with the use of Cissus quadrangularis and Dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritis |
| title_full | Early experience with the use of Cissus quadrangularis and Dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritis |
| title_fullStr | Early experience with the use of Cissus quadrangularis and Dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritis |
| title_full_unstemmed | Early experience with the use of Cissus quadrangularis and Dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritis |
| title_short | Early experience with the use of Cissus quadrangularis and Dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritis |
| title_sort | early experience with the use of cissus quadrangularis and dalbergia sissoo therapy on bone marrow edema and knee pain associated with degenerative medial compartment knee osteoarthritis |
| topic | bone marrow edema; cissus quadrangularis; dalbergia sissoo; osteoarthritis |
| url | https://www.nepjol.info/index.php/AJMS/article/view/61272 |
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