Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms
Zinc transporters take up/release zinc ions (Zn<sup>2+</sup>) across biological membranes and maintain intracellular and intra-organellar Zn<sup>2+</sup> homeostasis. Since this process requires a series of conformational changes in the transporters, detailed information abou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/3045 |
| _version_ | 1797264343094525952 |
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| author | Han Ba Bui Kenji Inaba |
| author_facet | Han Ba Bui Kenji Inaba |
| author_sort | Han Ba Bui |
| collection | DOAJ |
| description | Zinc transporters take up/release zinc ions (Zn<sup>2+</sup>) across biological membranes and maintain intracellular and intra-organellar Zn<sup>2+</sup> homeostasis. Since this process requires a series of conformational changes in the transporters, detailed information about the structures of different reaction intermediates is required for a comprehensive understanding of their Zn<sup>2+</sup> transport mechanisms. Recently, various Zn<sup>2+</sup> transport systems have been identified in bacteria, yeasts, plants, and humans. Based on structural analyses of human ZnT7, human ZnT8, and bacterial YiiP, we propose updated models explaining their mechanisms of action to ensure efficient Zn<sup>2+</sup> transport. We place particular focus on the mechanistic roles of the histidine-rich loop shared by several zinc transporters, which facilitates Zn<sup>2+</sup> recruitment to the transmembrane Zn<sup>2+</sup>-binding site. This review provides an extensive overview of the structures, mechanisms, and physiological functions of zinc transporters in different biological kingdoms. |
| first_indexed | 2024-04-25T00:27:23Z |
| format | Article |
| id | doaj.art-172238f21c374264b73b3ee897010ada |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:27:23Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-172238f21c374264b73b3ee897010ada2024-03-12T16:47:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01255304510.3390/ijms25053045Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological KingdomsHan Ba Bui0Kenji Inaba1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, JapanInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, JapanZinc transporters take up/release zinc ions (Zn<sup>2+</sup>) across biological membranes and maintain intracellular and intra-organellar Zn<sup>2+</sup> homeostasis. Since this process requires a series of conformational changes in the transporters, detailed information about the structures of different reaction intermediates is required for a comprehensive understanding of their Zn<sup>2+</sup> transport mechanisms. Recently, various Zn<sup>2+</sup> transport systems have been identified in bacteria, yeasts, plants, and humans. Based on structural analyses of human ZnT7, human ZnT8, and bacterial YiiP, we propose updated models explaining their mechanisms of action to ensure efficient Zn<sup>2+</sup> transport. We place particular focus on the mechanistic roles of the histidine-rich loop shared by several zinc transporters, which facilitates Zn<sup>2+</sup> recruitment to the transmembrane Zn<sup>2+</sup>-binding site. This review provides an extensive overview of the structures, mechanisms, and physiological functions of zinc transporters in different biological kingdoms.https://www.mdpi.com/1422-0067/25/5/3045zinc transporterZnTYiiPhistidine-rich loopcryo-EM |
| spellingShingle | Han Ba Bui Kenji Inaba Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms International Journal of Molecular Sciences zinc transporter ZnT YiiP histidine-rich loop cryo-EM |
| title | Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms |
| title_full | Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms |
| title_fullStr | Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms |
| title_full_unstemmed | Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms |
| title_short | Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms |
| title_sort | structures mechanisms and physiological functions of zinc transporters in different biological kingdoms |
| topic | zinc transporter ZnT YiiP histidine-rich loop cryo-EM |
| url | https://www.mdpi.com/1422-0067/25/5/3045 |
| work_keys_str_mv | AT hanbabui structuresmechanismsandphysiologicalfunctionsofzinctransportersindifferentbiologicalkingdoms AT kenjiinaba structuresmechanismsandphysiologicalfunctionsofzinctransportersindifferentbiologicalkingdoms |