Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention
Abstract Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via A...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-09-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01624-6 |
| _version_ | 1827635530901225472 |
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| author | Zhenyu Zhang Minnan Chen Wenjing Zhan Yuechun Chen Tongtong Wang Zhonghua Chen Yifei Fu Gang Zhao Dong Mao Jingjing Ruan Feng-Lai Yuan |
| author_facet | Zhenyu Zhang Minnan Chen Wenjing Zhan Yuechun Chen Tongtong Wang Zhonghua Chen Yifei Fu Gang Zhao Dong Mao Jingjing Ruan Feng-Lai Yuan |
| author_sort | Zhenyu Zhang |
| collection | DOAJ |
| description | Abstract Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca2+‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies. |
| first_indexed | 2024-03-09T15:28:56Z |
| format | Article |
| id | doaj.art-17241a19dd864c518a9a0150f53f246f |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-03-09T15:28:56Z |
| publishDate | 2023-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-17241a19dd864c518a9a0150f53f246f2023-11-26T12:21:37ZengNature Publishing GroupCell Death Discovery2058-77162023-09-019111110.1038/s41420-023-01624-6Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic interventionZhenyu Zhang0Minnan Chen1Wenjing Zhan2Yuechun Chen3Tongtong Wang4Zhonghua Chen5Yifei Fu6Gang Zhao7Dong Mao8Jingjing Ruan9Feng-Lai Yuan10Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan UniversityNantong First People’s Hospital The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical UniversityInstitute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan UniversityInstitute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan UniversityInstitute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan UniversityInstitute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan UniversityOrthopaedic Institute, Wuxi 9th People’s Hospital Affiliated to Soochow UniversityOrthopaedic Institute, Wuxi 9th People’s Hospital Affiliated to Soochow UniversityNantong First People’s HospitalInstitute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan UniversityAbstract Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca2+‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.https://doi.org/10.1038/s41420-023-01624-6 |
| spellingShingle | Zhenyu Zhang Minnan Chen Wenjing Zhan Yuechun Chen Tongtong Wang Zhonghua Chen Yifei Fu Gang Zhao Dong Mao Jingjing Ruan Feng-Lai Yuan Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention Cell Death Discovery |
| title | Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention |
| title_full | Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention |
| title_fullStr | Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention |
| title_full_unstemmed | Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention |
| title_short | Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention |
| title_sort | acid sensing ion channel 1a modulation of apoptosis in acidosis related diseases implications for therapeutic intervention |
| url | https://doi.org/10.1038/s41420-023-01624-6 |
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