The Effect of PRP Augmentation of Arthroscopic Repairs of Shoulder Rotator Cuff Tears on Postoperative Clinical Scores and Retear Rates: A Systematic Review and Meta-Analysis
The aim of this review and meta-analysis is to assess recent clinical trials concerning the combination of operative treatment of rotator cuff tears and the administration of PRP and its effect on clinical scores and postoperative retear rates. The trials were used to compare the combination of PRP...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/2/581 |
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| author | Ioannis Angelos Trantos Elias S. Vasiliadis Filippos S. Giannoulis Eleni Pappa Fotios Kakridonis Spyros G. Pneumaticos |
| author_facet | Ioannis Angelos Trantos Elias S. Vasiliadis Filippos S. Giannoulis Eleni Pappa Fotios Kakridonis Spyros G. Pneumaticos |
| author_sort | Ioannis Angelos Trantos |
| collection | DOAJ |
| description | The aim of this review and meta-analysis is to assess recent clinical trials concerning the combination of operative treatment of rotator cuff tears and the administration of PRP and its effect on clinical scores and postoperative retear rates. The trials were used to compare the combination of PRP treatment and arthroscopic rotator cuff repair to arthroscopy alone. Twenty-five clinical trials were reviewed. A risk-of-bias assessment was made for all randomized clinical trials included, using the Cochrane collaboration’s tool as well as a quality assessment for all non-randomized studies utilizing the Newcastle–Ottawa scale. The PRP-treated patients showed statistically significant improvement postoperatively compared to control groups concerning the Constant–Murley (mean difference 2.46, 95% CI 1.4–3.52, <i>p</i> < 0.00001), SST (mean difference 0.32, 95% CI 0.02–0.63, <i>p</i> = 0.04), and UCLA (mean difference 0.82, 95% CI 0.23–1.43, <i>p</i> = 0.07) scores. A statistically significant decrease of retear rates in the PRP-treated patients, with a risk ratio of 0.78 (95% CI 0.65–0.94, <i>p</i> = 0.01), was found. We believe that the results presented have positive aspects, especially concerning the retear risk, but are yet inconclusive concerning clinical results such as shoulder pain and function. |
| first_indexed | 2024-03-09T12:11:27Z |
| format | Article |
| id | doaj.art-1724fc0d0f1d448899e79c5013fc982f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:11:27Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1724fc0d0f1d448899e79c5013fc982f2023-11-30T22:51:54ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112258110.3390/jcm12020581The Effect of PRP Augmentation of Arthroscopic Repairs of Shoulder Rotator Cuff Tears on Postoperative Clinical Scores and Retear Rates: A Systematic Review and Meta-AnalysisIoannis Angelos Trantos0Elias S. Vasiliadis1Filippos S. Giannoulis2Eleni Pappa3Fotios Kakridonis4Spyros G. Pneumaticos55th Department of Orthopaedic Surgery, KAT Hospital, 14561 Athens, Greece3rd Department of Orthopaedic Surgery, KAT Hospital, University of Athens, 14561 Athens, GreeceHand, Upper Extremity and Microsurgery Department, KAT Hospital, 14561 Athens, Greece5th Department of Orthopaedic Surgery, KAT Hospital, 14561 Athens, Greece5th Department of Orthopaedic Surgery, KAT Hospital, 14561 Athens, Greece3rd Department of Orthopaedic Surgery, KAT Hospital, University of Athens, 14561 Athens, GreeceThe aim of this review and meta-analysis is to assess recent clinical trials concerning the combination of operative treatment of rotator cuff tears and the administration of PRP and its effect on clinical scores and postoperative retear rates. The trials were used to compare the combination of PRP treatment and arthroscopic rotator cuff repair to arthroscopy alone. Twenty-five clinical trials were reviewed. A risk-of-bias assessment was made for all randomized clinical trials included, using the Cochrane collaboration’s tool as well as a quality assessment for all non-randomized studies utilizing the Newcastle–Ottawa scale. The PRP-treated patients showed statistically significant improvement postoperatively compared to control groups concerning the Constant–Murley (mean difference 2.46, 95% CI 1.4–3.52, <i>p</i> < 0.00001), SST (mean difference 0.32, 95% CI 0.02–0.63, <i>p</i> = 0.04), and UCLA (mean difference 0.82, 95% CI 0.23–1.43, <i>p</i> = 0.07) scores. A statistically significant decrease of retear rates in the PRP-treated patients, with a risk ratio of 0.78 (95% CI 0.65–0.94, <i>p</i> = 0.01), was found. We believe that the results presented have positive aspects, especially concerning the retear risk, but are yet inconclusive concerning clinical results such as shoulder pain and function.https://www.mdpi.com/2077-0383/12/2/581arthroscopygrowth factorsplatelet-rich plasmaplatelet-rich fibrinrotator cuff tearsshoulder injuries |
| spellingShingle | Ioannis Angelos Trantos Elias S. Vasiliadis Filippos S. Giannoulis Eleni Pappa Fotios Kakridonis Spyros G. Pneumaticos The Effect of PRP Augmentation of Arthroscopic Repairs of Shoulder Rotator Cuff Tears on Postoperative Clinical Scores and Retear Rates: A Systematic Review and Meta-Analysis Journal of Clinical Medicine arthroscopy growth factors platelet-rich plasma platelet-rich fibrin rotator cuff tears shoulder injuries |
| title | The Effect of PRP Augmentation of Arthroscopic Repairs of Shoulder Rotator Cuff Tears on Postoperative Clinical Scores and Retear Rates: A Systematic Review and Meta-Analysis |
| title_full | The Effect of PRP Augmentation of Arthroscopic Repairs of Shoulder Rotator Cuff Tears on Postoperative Clinical Scores and Retear Rates: A Systematic Review and Meta-Analysis |
| title_fullStr | The Effect of PRP Augmentation of Arthroscopic Repairs of Shoulder Rotator Cuff Tears on Postoperative Clinical Scores and Retear Rates: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Effect of PRP Augmentation of Arthroscopic Repairs of Shoulder Rotator Cuff Tears on Postoperative Clinical Scores and Retear Rates: A Systematic Review and Meta-Analysis |
| title_short | The Effect of PRP Augmentation of Arthroscopic Repairs of Shoulder Rotator Cuff Tears on Postoperative Clinical Scores and Retear Rates: A Systematic Review and Meta-Analysis |
| title_sort | effect of prp augmentation of arthroscopic repairs of shoulder rotator cuff tears on postoperative clinical scores and retear rates a systematic review and meta analysis |
| topic | arthroscopy growth factors platelet-rich plasma platelet-rich fibrin rotator cuff tears shoulder injuries |
| url | https://www.mdpi.com/2077-0383/12/2/581 |
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