The effects of macronutrients metabolism on cellular and organismal aging
Evidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. For this reason, dietary interventions and compounds perturbing metabolism are currently explored as anti-aging strategies. A common target...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417023000094 |
| _version_ | 1797792572886745088 |
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| author | Jamil Nehme Abdullah Altulea Teodora Gheorghe Marco Demaria |
| author_facet | Jamil Nehme Abdullah Altulea Teodora Gheorghe Marco Demaria |
| author_sort | Jamil Nehme |
| collection | DOAJ |
| description | Evidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. For this reason, dietary interventions and compounds perturbing metabolism are currently explored as anti-aging strategies. A common target for metabolic interventions delaying aging is cellular senescence, a state of stable growth arrest that is accompanied by various structural and functional changes including the activation of a pro-inflammatory secretome. Here, we summarize the current knowledge on the molecular and cellular events associated with carbohydrate, lipid and protein metabolism, and define how macronutrients can regulate induction or prevention of cellular senescence. We discuss how various dietary interventions can achieve prevention of disease and extension of healthy longevity by partially modulating senescence-associated phenotypes. We also emphasize the importance of developing personalized nutritional interventions that take into account the current health and age status of the individual. |
| first_indexed | 2024-03-13T02:35:59Z |
| format | Article |
| id | doaj.art-17259e5ebb3e4107b67d8b9c3eabb2e0 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-03-13T02:35:59Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-17259e5ebb3e4107b67d8b9c3eabb2e02023-06-29T04:14:27ZengElsevierBiomedical Journal2319-41702023-06-01463100585The effects of macronutrients metabolism on cellular and organismal agingJamil Nehme0Abdullah Altulea1Teodora Gheorghe2Marco Demaria3University of Groningen, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), Groningen, NetherlandsUniversity of Groningen, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), Groningen, NetherlandsUniversity of Groningen, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), Groningen, NetherlandsCorresponding author. University of Groningen, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), Broerstraat, 9712 ER Groningen, Groningen, Netherlands.; University of Groningen, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), Groningen, NetherlandsEvidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. For this reason, dietary interventions and compounds perturbing metabolism are currently explored as anti-aging strategies. A common target for metabolic interventions delaying aging is cellular senescence, a state of stable growth arrest that is accompanied by various structural and functional changes including the activation of a pro-inflammatory secretome. Here, we summarize the current knowledge on the molecular and cellular events associated with carbohydrate, lipid and protein metabolism, and define how macronutrients can regulate induction or prevention of cellular senescence. We discuss how various dietary interventions can achieve prevention of disease and extension of healthy longevity by partially modulating senescence-associated phenotypes. We also emphasize the importance of developing personalized nutritional interventions that take into account the current health and age status of the individual.http://www.sciencedirect.com/science/article/pii/S2319417023000094AgingMacronutrientsMetabolismSenescence |
| spellingShingle | Jamil Nehme Abdullah Altulea Teodora Gheorghe Marco Demaria The effects of macronutrients metabolism on cellular and organismal aging Biomedical Journal Aging Macronutrients Metabolism Senescence |
| title | The effects of macronutrients metabolism on cellular and organismal aging |
| title_full | The effects of macronutrients metabolism on cellular and organismal aging |
| title_fullStr | The effects of macronutrients metabolism on cellular and organismal aging |
| title_full_unstemmed | The effects of macronutrients metabolism on cellular and organismal aging |
| title_short | The effects of macronutrients metabolism on cellular and organismal aging |
| title_sort | effects of macronutrients metabolism on cellular and organismal aging |
| topic | Aging Macronutrients Metabolism Senescence |
| url | http://www.sciencedirect.com/science/article/pii/S2319417023000094 |
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