Associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth size
As an alternative to legacy perfluorooctane sulfonate (PFOS), the wide usage of chlorinated polyfluoroalkyl ether sulfonic acid (Cl-PFESA) in China has generated considerable concerns. The study aimed to investigate the associations between cord serum emerging Cl-PFESA (6:2 Cl-PFESA and 8:2 Cl-PFESA...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Hygiene and Environmental Health Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773049222000344 |
| _version_ | 1797740769132412928 |
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| author | Hong-Xiu Liu Yun Huang Yi-Tao Pan Xiao-Jie Sun Yuan-Yuan Li Ai-Fen Zhou Jia-Yin Dai Han Li Shun-Qing Xu Shi Lu |
| author_facet | Hong-Xiu Liu Yun Huang Yi-Tao Pan Xiao-Jie Sun Yuan-Yuan Li Ai-Fen Zhou Jia-Yin Dai Han Li Shun-Qing Xu Shi Lu |
| author_sort | Hong-Xiu Liu |
| collection | DOAJ |
| description | As an alternative to legacy perfluorooctane sulfonate (PFOS), the wide usage of chlorinated polyfluoroalkyl ether sulfonic acid (Cl-PFESA) in China has generated considerable concerns. The study aimed to investigate the associations between cord serum emerging Cl-PFESA (6:2 Cl-PFESA and 8:2 Cl-PFESA) levels and suboptimal birth size, including low birth weight (LBW), macrosomia, small or large for gestational age (SGA or LGA) among 1048 newborns in Wuhan, China. 6:2 Cl-PFESA and 8:2 Cl-PFESA were 0.76 ng/mL and 0.03 ng/mL, respectively, higher than previously reported levels in newborns from other cities in China. We did not find significant associations between the Cl-PFESAs and suboptimal birth size when considering each Cl-PFESA as a single exposure. However, when integrating emerging Cl-PFESAs and legacy PFASs (PFOS and perfluorooctanoate acid (PFOA)) as a mixture using Bayesian kernel machine regression (BKMR) models, we found that the mixture of legacy PFASs and emerging Cl-PFESAs had inverse associations with SGA and LGA. Two legacy PFASs and two Cl-PFESAs had similar contributions to the association with SGA, whereas the majority of the association with LGA was driven by PFOS. The results demonstrated these legacy PFASs were still the predominant PFASs associated with suboptimal birth size while emerging Cl-PFESAs had a less but nonnegligible contribution to the association with SGA. Further studies in different regions with varied Cl-PFESA levels are needed to replicate the associations. |
| first_indexed | 2024-03-12T14:17:09Z |
| format | Article |
| id | doaj.art-1727792925704c7c8f1a54ce394d6319 |
| institution | Directory Open Access Journal |
| issn | 2773-0492 |
| language | English |
| last_indexed | 2024-03-12T14:17:09Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hygiene and Environmental Health Advances |
| spelling | doaj.art-1727792925704c7c8f1a54ce394d63192023-08-20T04:39:01ZengElsevierHygiene and Environmental Health Advances2773-04922022-12-014100034Associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth sizeHong-Xiu Liu0Yun Huang1Yi-Tao Pan2Xiao-Jie Sun3Yuan-Yuan Li4Ai-Fen Zhou5Jia-Yin Dai6Han Li7Shun-Qing Xu8Shi Lu9Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China; Department of occupational and environmental health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China; Corresponding authors.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China; Department of occupational and environmental health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, ChinaSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China; Department of occupational and environmental health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, ChinaKey Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China; Department of occupational and environmental health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, ChinaWomen and Children Medical and Healthcare Center of Wuhan, Hubei, ChinaSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Guangxi, ChinaKey Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China; Department of occupational and environmental health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, ChinaDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China; Corresponding authors.As an alternative to legacy perfluorooctane sulfonate (PFOS), the wide usage of chlorinated polyfluoroalkyl ether sulfonic acid (Cl-PFESA) in China has generated considerable concerns. The study aimed to investigate the associations between cord serum emerging Cl-PFESA (6:2 Cl-PFESA and 8:2 Cl-PFESA) levels and suboptimal birth size, including low birth weight (LBW), macrosomia, small or large for gestational age (SGA or LGA) among 1048 newborns in Wuhan, China. 6:2 Cl-PFESA and 8:2 Cl-PFESA were 0.76 ng/mL and 0.03 ng/mL, respectively, higher than previously reported levels in newborns from other cities in China. We did not find significant associations between the Cl-PFESAs and suboptimal birth size when considering each Cl-PFESA as a single exposure. However, when integrating emerging Cl-PFESAs and legacy PFASs (PFOS and perfluorooctanoate acid (PFOA)) as a mixture using Bayesian kernel machine regression (BKMR) models, we found that the mixture of legacy PFASs and emerging Cl-PFESAs had inverse associations with SGA and LGA. Two legacy PFASs and two Cl-PFESAs had similar contributions to the association with SGA, whereas the majority of the association with LGA was driven by PFOS. The results demonstrated these legacy PFASs were still the predominant PFASs associated with suboptimal birth size while emerging Cl-PFESAs had a less but nonnegligible contribution to the association with SGA. Further studies in different regions with varied Cl-PFESA levels are needed to replicate the associations.http://www.sciencedirect.com/science/article/pii/S2773049222000344Cl-PFESAsPFASsBirth sizeMixtureCohort |
| spellingShingle | Hong-Xiu Liu Yun Huang Yi-Tao Pan Xiao-Jie Sun Yuan-Yuan Li Ai-Fen Zhou Jia-Yin Dai Han Li Shun-Qing Xu Shi Lu Associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth size Hygiene and Environmental Health Advances Cl-PFESAs PFASs Birth size Mixture Cohort |
| title | Associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth size |
| title_full | Associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth size |
| title_fullStr | Associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth size |
| title_full_unstemmed | Associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth size |
| title_short | Associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth size |
| title_sort | associations between emerging chlorinated polyfluoroalkyl ether sulfonic acids exposure and birth size |
| topic | Cl-PFESAs PFASs Birth size Mixture Cohort |
| url | http://www.sciencedirect.com/science/article/pii/S2773049222000344 |
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