Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance
Polychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose toleran...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1085958/full |
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| author | Brittany B. Rice Keegan W. Sammons Sara Y. Ngo Tenlep Madeline T. Weltzer Leryn J. Reynolds Cetewayo S. Rashid Hollie I. Swanson Kevin J. Pearson |
| author_facet | Brittany B. Rice Keegan W. Sammons Sara Y. Ngo Tenlep Madeline T. Weltzer Leryn J. Reynolds Cetewayo S. Rashid Hollie I. Swanson Kevin J. Pearson |
| author_sort | Brittany B. Rice |
| collection | DOAJ |
| description | Polychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose tolerance and/or body composition profiles. The purpose of this study was to investigate the glucose tolerance and body composition of offspring born to dams exposed to PCB126 during the nursing period only. Female ICR mice were bred, and half of the dams were exposed to either vehicle (safflower oil) or 1 µmole PCB126 per kg of body weight via oral gavage on postnatal days (PND) 3, 10, and 17 (n = 9 per group). Offspring body weight, lean and fat mass, and glucose tolerance were recorded every three weeks. PCB126 treatment did not alter dam nor offspring body weight (p > 0.05). PCB126-exposed male and female offspring displayed normal body composition (p > 0.05) relative to vehicle-exposed offspring. However, both male and female offspring that were exposed to PCB126 during the nursing period had significantly impaired glucose tolerance at 3 and 9 weeks of age (p < 0.05). At 6 and 12 weeks of age, no impairments in glucose tolerance existed in offspring (p > 0.05). Our current study demonstrates that exposure to PCB126 through the mother’s milk does not affect short- or long-term body composition but impairs glucose tolerance in the short-term. |
| first_indexed | 2024-04-09T23:18:13Z |
| format | Article |
| id | doaj.art-172b7aa805f14421838f07b501854e1e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T23:18:13Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-172b7aa805f14421838f07b501854e1e2023-03-22T05:00:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.10859581085958Exposure to PCB126 during the nursing period reversibly impacts early-life glucose toleranceBrittany B. Rice0Keegan W. Sammons1Sara Y. Ngo Tenlep2Madeline T. Weltzer3Leryn J. Reynolds4Cetewayo S. Rashid5Hollie I. Swanson6Kevin J. Pearson7Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United StatesHuman Movement Sciences, Darden College of Education, Old Dominion University, Norfolk, VA, United StatesDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United StatesPolychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose tolerance and/or body composition profiles. The purpose of this study was to investigate the glucose tolerance and body composition of offspring born to dams exposed to PCB126 during the nursing period only. Female ICR mice were bred, and half of the dams were exposed to either vehicle (safflower oil) or 1 µmole PCB126 per kg of body weight via oral gavage on postnatal days (PND) 3, 10, and 17 (n = 9 per group). Offspring body weight, lean and fat mass, and glucose tolerance were recorded every three weeks. PCB126 treatment did not alter dam nor offspring body weight (p > 0.05). PCB126-exposed male and female offspring displayed normal body composition (p > 0.05) relative to vehicle-exposed offspring. However, both male and female offspring that were exposed to PCB126 during the nursing period had significantly impaired glucose tolerance at 3 and 9 weeks of age (p < 0.05). At 6 and 12 weeks of age, no impairments in glucose tolerance existed in offspring (p > 0.05). Our current study demonstrates that exposure to PCB126 through the mother’s milk does not affect short- or long-term body composition but impairs glucose tolerance in the short-term.https://www.frontiersin.org/articles/10.3389/fendo.2023.1085958/fullobesitypolychlorinated biophenylsdiabetesmicedevelopmental programming of adult diseaseDOHaD (development origins of health and disease) |
| spellingShingle | Brittany B. Rice Keegan W. Sammons Sara Y. Ngo Tenlep Madeline T. Weltzer Leryn J. Reynolds Cetewayo S. Rashid Hollie I. Swanson Kevin J. Pearson Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance Frontiers in Endocrinology obesity polychlorinated biophenyls diabetes mice developmental programming of adult disease DOHaD (development origins of health and disease) |
| title | Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance |
| title_full | Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance |
| title_fullStr | Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance |
| title_full_unstemmed | Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance |
| title_short | Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance |
| title_sort | exposure to pcb126 during the nursing period reversibly impacts early life glucose tolerance |
| topic | obesity polychlorinated biophenyls diabetes mice developmental programming of adult disease DOHaD (development origins of health and disease) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1085958/full |
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