Antibody-Based In Vivo Imaging of Central Nervous System Targets—Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines

Antibody-Based In Vivo Imaging of Central Nervous System Targets—Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines

Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels–Alder (IEDDA) reaction between a tetrazine (Tz) and a <i>trans</i>-cyclooctene (TCO) represents an attractive strategy for molecular imaging via antibodies. The advantages of using a pretargeted imaging approach ar...

Full description

Bibliographic Details
Main Authors:	Christoph Bredack, Martin R. Edelmann, Edilio Borroni, Luca C. Gobbi, Michael Honer
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	Pharmaceuticals
Subjects:	antibody click chemistry CNS PET pretargeting tetrazine
Online Access:	https://www.mdpi.com/1424-8247/15/12/1445

Similar Items

Development of <sup>18</sup>F-Labeled Bispyridyl Tetrazines for In Vivo Pretargeted PET Imaging
by: Rocío García-Vázquez, et al.
Published: (2022-02-01)

Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging
by: Rocío García-Vázquez, et al.
Published: (2022-05-01)

Modified poly-L-lysine for use as a clearing agent in pretargeted radioimmunotherapy
by: Chiara Timperanza, et al.
Published: (2024-11-01)

Clearing and Masking Agents in Pretargeting Strategies
by: Markus Staudt, et al.
Published: (2023-03-01)

In vitro and in vivo evaluation of a tetrazine-conjugated poly-L-lysine effector molecule labeled with astatine-211
by: Chiara Timperanza, et al.
Published: (2024-05-01)

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
by: Sara Lopes van den Broek, et al.
Published: (2022-09-01)

Optimization of Direct Aromatic <sup>18</sup>F-Labeling of Tetrazines
by: Ida Vang Andersen, et al.
Published: (2022-06-01)

Evaluation of [<sup>64</sup>Cu]Cu-NOTA-PEG<sub>7</sub>-H-Tz for Pretargeted Imaging in LS174T Xenografts—Comparison to [<sup>111</sup>In]In-DOTA-PEG<sub>11</sub>-BisPy-Tz
by: Christian B. M. Poulie, et al.
Published: (2021-01-01)

Covalent Immobilization of Antibodies through Tetrazine-TCO Reaction to Improve Sensitivity of ELISA Technique
by: Tania García-Maceira, et al.
Published: (2021-12-01)

Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes
by: Sang-Kee Choi, et al.
Published: (2021-03-01)

IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications
by: Maryana Handula, et al.
Published: (2021-07-01)

Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?
by: Sara Lopes van den Broek, et al.
Published: (2022-09-01)

A proof-of-concept study on bioorthogonal-based pretargeting and signal amplify radiotheranostic strategy
by: Hongzhang Yang, et al.
Published: (2024-03-01)

Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and Astatine-211
by: Chiara Timperanza, et al.
Published: (2023-04-01)

Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
by: Yayue Wang, et al.
Published: (2020-11-01)

A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery
by: Min Kyung Khang, et al.
Published: (2020-12-01)

Functionalization and Crosslinking of Reduced Graphene Oxide Sheets by Multiple Tetrazine Units to Improve the Energy Storage in Supercapacitors
by: Dr. Margarita Bosmi, et al.
Published: (2024-01-01)

Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers
by: Alice D’Onofrio, et al.
Published: (2022-11-01)

Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
by: Jiayu Sun, et al.
Published: (2021-01-01)

Antituberculosis activity of some 3,6-disubstituted 1,2,4,5-tetrazines
by: Rashida I. Ishmetova, et al.
Published: (2024-11-01)

Redox Potential Tuning of s-Tetrazine by Substitution of Electron-Withdrawing/Donating Groups for Organic Electrode Materials
by: Dong Joo Min, et al.
Published: (2021-02-01)

Coordination Chemistry of a Bis(Tetrazine) Tweezer: A Case of Host-Guest Behavior with Silver Salts
by: Clève D. Mboyi, et al.
Published: (2021-05-01)

Matthew effect: General design strategy of ultra‐fluorogenic nanoprobes with amplified dark–bright states in aggregates
by: Shinsuke Segawa, et al.
Published: (2024-04-01)

Computational assessment of nitrogen-enriched, stable and insensitive tris(1,2,4,5-tetrazin-3-yl)amine building block for energetic applications
by: Anjali Maan, et al.
Published: (2022-03-01)

Synthesis and properties of a promising high energy and low impact sensitivity explosive: hydroxylammonium 3-hydrazino-6-(1H-1,2,3,4-tetrazol-5-ylimino)-s-tetrazine
by: Zihan Zhang, et al.
Published: (2023-03-01)

Recent advances in the synthesis and performance of 1,2,4,5-tetrazine-based energetic materials
by: Leonid L. Fershtat
Published: (2023-03-01)

Synthesis and crystal structure of 2,2,2-trichloroethyl N-{4-[6-(1-hydroxyethyl)-1,2,4,5-tetrazin-3-yl]benzyl}carbamate
by: J. Voss, et al.
Published: (2025-02-01)

Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine
by: Jason Beaufrez, et al.
Published: (2023-04-01)

Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
by: Eva Schlein, et al.
Published: (2024-03-01)

Mechanism, Kinetics and Thermodynamics of Decomposition for High Energy Derivatives of [1,2,4]Triazolo[4,3-<i>b</i>][1,2,4,5]tetrazine
by: Aleksandr V. Stankevich, et al.
Published: (2022-10-01)

Initial Steps towards Spatiotemporal Signaling through Biomaterials Using Click-to-Release Chemistry
by: Merel Gansevoort, et al.
Published: (2022-09-01)

Synthesis and Luminescent Properties of <i>s</i>-Tetrazine Derivatives Conjugated with the 4<i>H</i>-1,2,4-Triazole Ring
by: Anna Maj, et al.
Published: (2022-06-01)

Development of Polar BODIPY-Tetrazines for Rapid Pretargeted Fluorescence Imaging
by: Markus Staudt, et al.
Published: (2024-09-01)

Novel Conjugated <i>s</i>-Tetrazine Derivatives Bearing a 4<i>H</i>-1,2,4-Triazole Scaffold: Synthesis and Luminescent Properties
by: Anna Maj, et al.
Published: (2022-01-01)

Synthesis and Characteristics of 1,2,4,5-Tetrazines for Using as High Energy Density Materials (HEDMs)
by: Sebastian Górecki, et al.
Published: (2025-01-01)

Design, synthesis and anti-oxidant activities of novel 1,2,3,4-tetrazine, 1,2,3-triazoles and coumarin derivatives and their nanoparticular encapsulation
by: Oznur Eyilcim, et al.
Published: (2024-01-01)

Mono- and Binuclear Copper(II) and Nickel(II) Complexes with the 3,6-Bis(picolylamino)-1,2,4,5-Tetrazine Ligand
by: Oleh Stetsiuk, et al.
Published: (2021-04-01)

Hybrid Imaging Agents for Pretargeting Applications Based on Fusarinine C—Proof of Concept
by: Dominik Summer, et al.
Published: (2020-05-01)

Central Nervous System Disorders with Auto-Antibodies in People Living with HIV
by: Giacomo Stroffolini, et al.
Published: (2024-08-01)

MODIFICATION OF [18F]FDG BY THE FORMATION OF A HYDRAZONE BOND
by: Gergana Simeonova, et al.
Published: (2023-02-01)