Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh
Abstract Background To assess the maternal characteristics and nutritional status according to body mass index (BMI) at 6–14 weeks of gestation and to examine the relationship between maternal nutritional status in early pregnancy and its impact on neonatal birth weight. Methods The investigation wa...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | http://link.springer.com/article/10.1186/s12884-019-2571-5 |
| _version_ | 1818116687807905792 |
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| author | Bishwajit Bhowmik Tasnima Siddique Anindita Majumder Ibrahimu Mdala Israt A. Hossain Zahid Hassan Ishrat Jahan Nayla Cristina do V. Moreira Abdul Alim Abdul Basit Graham A. Hitman Abul Kalam A. Khan Akhtar Hussain |
| author_facet | Bishwajit Bhowmik Tasnima Siddique Anindita Majumder Ibrahimu Mdala Israt A. Hossain Zahid Hassan Ishrat Jahan Nayla Cristina do V. Moreira Abdul Alim Abdul Basit Graham A. Hitman Abul Kalam A. Khan Akhtar Hussain |
| author_sort | Bishwajit Bhowmik |
| collection | DOAJ |
| description | Abstract Background To assess the maternal characteristics and nutritional status according to body mass index (BMI) at 6–14 weeks of gestation and to examine the relationship between maternal nutritional status in early pregnancy and its impact on neonatal birth weight. Methods The investigation was conducted from April 2011 to June 2012 in Dhaka, Bangladesh. A total of 498 primigravida pregnant women participated in the study; women with known diabetes or previous gestational diabetes (GDM) were excluded. Maternal demographic details, pregnancy history and anthropometric measurements were obtained from the mother at the recruitment (6–14 weeks), 2nd visit between 24 and 28 week of gestation and 3rd visit at delivery. Cord venous blood samples of newborns (n = 138) were collected immediately after delivery for blood glucose, insulin, lipid profile, leptin and micronutrients including serum folate, ferritin, homocysteine, vitamin D, and vitamin B12. Results The prevalence at 6–14 weeks of pregnancy of anemia (Hb, < 11 g/dl), vitamin D deficiency (< 30 nmol/l), vitamin B12 deficiency (< 200 pg/ml), high homocysteine level (> 15 μmol/l), folate deficiency (< 3 ng/ml) and iron deficiency (ferritin < 13 ng/ml) were 19.5, 46.4, 15.1, 1.2, 0.4, and 12.7% respectively. GDM was found in 18.4% women. The prevalence of GDM was higher in overweight women (28.1%) than underweight (16.7%) and normal weight women (16.0%: p < 0.05). The incidence of low birth weight (LBW) and preterm delivery were 11.6 and 5.8% respectively and was not related to maternal BMI at 6–14 weeks of pregnancy. Maternal height was positively (p = 0.02), and homocysteine was negatively associated with neonatal birth weight (p = 0.02). In addition, the newborn’s cord serum folate was positively (p = 0.03) and cord triglyceride was negatively (p = 0.03) associated with neonatal birth weight. Conclusion Multiple maternal micronutrient deficiencies were present in early pregnancy. Maternal BMI in early pregnancy was not related to preterm deliveries or LBW. LBW was associated with lower folate, elevated cord triglyceride concentrations of the neonates and mother’s height and increase in maternal homocysteine levels. The data has important implications for pregnancy care in Bangladesh and other similar communities. |
| first_indexed | 2024-12-11T04:26:29Z |
| format | Article |
| id | doaj.art-172d3889078547de8b40ee3e594ac89c |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-11T04:26:29Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-172d3889078547de8b40ee3e594ac89c2022-12-22T01:20:58ZengBMCBMC Pregnancy and Childbirth1471-23932019-11-0119111410.1186/s12884-019-2571-5Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in BangladeshBishwajit Bhowmik0Tasnima Siddique1Anindita Majumder2Ibrahimu Mdala3Israt A. Hossain4Zahid Hassan5Ishrat Jahan6Nayla Cristina do V. Moreira7Abdul Alim8Abdul Basit9Graham A. Hitman10Abul Kalam A. Khan11Akhtar Hussain12Centre of Global Health Research, Diabetic Association of BangladeshCentre of Global Health Research, Diabetic Association of BangladeshDepartment of Pathology, Ibrahim Medical College, Diabetic Association of BangladeshInstitute of Health and Society, Faculty of Medicine, University of OsloDepartment of Biochemistry & Cell Biology, Bangladesh University of Health SciencesDept of Physiology and Molecular Biology, Bangladesh University of Health SciencesMaternal and Child Health Training InstituteInstitute of Health and Society, Faculty of Medicine, University of OsloCentre of Global Health Research, Diabetic Association of BangladeshBaquai Institute of Diabetology and Endocrinology, Baquai Medical UniversityBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonCentre of Global Health Research, Diabetic Association of BangladeshCentre of Global Health Research, Diabetic Association of BangladeshAbstract Background To assess the maternal characteristics and nutritional status according to body mass index (BMI) at 6–14 weeks of gestation and to examine the relationship between maternal nutritional status in early pregnancy and its impact on neonatal birth weight. Methods The investigation was conducted from April 2011 to June 2012 in Dhaka, Bangladesh. A total of 498 primigravida pregnant women participated in the study; women with known diabetes or previous gestational diabetes (GDM) were excluded. Maternal demographic details, pregnancy history and anthropometric measurements were obtained from the mother at the recruitment (6–14 weeks), 2nd visit between 24 and 28 week of gestation and 3rd visit at delivery. Cord venous blood samples of newborns (n = 138) were collected immediately after delivery for blood glucose, insulin, lipid profile, leptin and micronutrients including serum folate, ferritin, homocysteine, vitamin D, and vitamin B12. Results The prevalence at 6–14 weeks of pregnancy of anemia (Hb, < 11 g/dl), vitamin D deficiency (< 30 nmol/l), vitamin B12 deficiency (< 200 pg/ml), high homocysteine level (> 15 μmol/l), folate deficiency (< 3 ng/ml) and iron deficiency (ferritin < 13 ng/ml) were 19.5, 46.4, 15.1, 1.2, 0.4, and 12.7% respectively. GDM was found in 18.4% women. The prevalence of GDM was higher in overweight women (28.1%) than underweight (16.7%) and normal weight women (16.0%: p < 0.05). The incidence of low birth weight (LBW) and preterm delivery were 11.6 and 5.8% respectively and was not related to maternal BMI at 6–14 weeks of pregnancy. Maternal height was positively (p = 0.02), and homocysteine was negatively associated with neonatal birth weight (p = 0.02). In addition, the newborn’s cord serum folate was positively (p = 0.03) and cord triglyceride was negatively (p = 0.03) associated with neonatal birth weight. Conclusion Multiple maternal micronutrient deficiencies were present in early pregnancy. Maternal BMI in early pregnancy was not related to preterm deliveries or LBW. LBW was associated with lower folate, elevated cord triglyceride concentrations of the neonates and mother’s height and increase in maternal homocysteine levels. The data has important implications for pregnancy care in Bangladesh and other similar communities.http://link.springer.com/article/10.1186/s12884-019-2571-5Maternal nutritionEarly pregnancyCardio-metabolic statusNewborns at birth |
| spellingShingle | Bishwajit Bhowmik Tasnima Siddique Anindita Majumder Ibrahimu Mdala Israt A. Hossain Zahid Hassan Ishrat Jahan Nayla Cristina do V. Moreira Abdul Alim Abdul Basit Graham A. Hitman Abul Kalam A. Khan Akhtar Hussain Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh BMC Pregnancy and Childbirth Maternal nutrition Early pregnancy Cardio-metabolic status Newborns at birth |
| title | Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh |
| title_full | Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh |
| title_fullStr | Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh |
| title_full_unstemmed | Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh |
| title_short | Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh |
| title_sort | maternal bmi and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in bangladesh |
| topic | Maternal nutrition Early pregnancy Cardio-metabolic status Newborns at birth |
| url | http://link.springer.com/article/10.1186/s12884-019-2571-5 |
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