Transmembrane Protein 100 Inhibits the Progression of Colorectal Cancer by Promoting the Ubiquitin/Proteasome Degradation of HIF-1α

Transmembrane Protein 100 Inhibits the Progression of Colorectal Cancer by Promoting the Ubiquitin/Proteasome Degradation of HIF-1α

Transmembrane protein 100 (TMEM100) is involved in embryonic cardiovascular system development. However, the biological role of TMEM100 in human cancers, particularly colorectal cancer (CRC), is unclear. In this study, tissue microarrays were stained using immunohistochemistry methods to evaluate th...

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Bibliographic Details
Main Authors: Ying Zheng, Yitong Zhao, Jiong Jiang, Baicang Zou, Lei Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
TMEM100
HIF-1α
ubiquitination/proteasome pathway
angiogenesis
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.899385/full

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