A clinico-immunohistopathological study of urothelial neoplasms with an expression of HER2/Neu and Ki-67 in malignant lesions presenting to a tertiary centre
Background: HER2/neu is associated with increased tumor grade, and Ki-67 is related to tumor recurrence and stage progression. This study aims to evaluate the clinical profile in patients with urothelial neoplasms and correlate the expression of HER2/neu and Ki-67 in urothelial carcinomas. Methods:...
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| Format: | Article |
| Language: | English |
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Golestan University Of Medical Sciences
2023-09-01
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| Series: | Journal of Clinical and Basic Research |
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| Online Access: | http://jcbr.goums.ac.ir/article-1-422-en.pdf |
| _version_ | 1797220379366785024 |
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| author | Fatima Rasheed Shilpa Karamchedu Venkata Hari Charan Bagadi Tabassum Misbah Manisha Goud Punjala Florence Nightingale Karamchedu Suresh |
| author_facet | Fatima Rasheed Shilpa Karamchedu Venkata Hari Charan Bagadi Tabassum Misbah Manisha Goud Punjala Florence Nightingale Karamchedu Suresh |
| author_sort | Fatima Rasheed |
| collection | DOAJ |
| description | Background: HER2/neu is associated with increased tumor grade, and Ki-67 is related to tumor recurrence and stage progression. This study aims to evaluate the clinical profile in patients with urothelial neoplasms and correlate the expression of HER2/neu and Ki-67 in urothelial carcinomas.
Methods: This is a five-year retrospective study from June 2017 to May 2022 with forty cases from the Department of Pathology. A microscopic examination was done to assess the tumor stage and histological grade. Immunohistochemistry was performed with HER2/neu and Ki-67.
Results: 65% (26/40) of the cases were diagnosed as infiltrating urothelial carcinoma, 30% (12) of the cases as low-grade non-invasive urothelial carcinoma, one case as a papillary urothelial neoplasm of low malignant potential (PUNLMP), and one case as urothelial papilloma. 95.5% of infiltrating carcinomas and 84.5% of low-grade non-invasive carcinomas were Ki-67-positive. A significant correlation was observed between the expression of Her-2/neu and Ki-67 and the 2016 World Health Organization (WHO) grading system of urothelial carcinoma. Moderate-to-strong HER2/neu overexpression (2+ or 3+) was observed in only 18% of cases.
Conclusion: The expression of ki-67 increased with an increase in the grade of tumor, which shows its prognostic importance. The relation between Ki-67 expression and the histologic grade of the tumor and the presence of lymphovascular invasion was significant. A significant correlation was observed between the grade of the carcinoma and the immunohistochemical expression of HER2/neu, in which 19.3% of high-grade carcinoma cases showed immunohistochemical expression of the HER2/neu marker. Further studies with a larger population group are required to establish the role of HER2/neu as a prognostic marker. |
| first_indexed | 2024-04-24T12:48:36Z |
| format | Article |
| id | doaj.art-1732a4a556bd4f5182a973805854964b |
| institution | Directory Open Access Journal |
| issn | 2538-3736 |
| language | English |
| last_indexed | 2024-04-24T12:48:36Z |
| publishDate | 2023-09-01 |
| publisher | Golestan University Of Medical Sciences |
| record_format | Article |
| series | Journal of Clinical and Basic Research |
| spelling | doaj.art-1732a4a556bd4f5182a973805854964b2024-04-06T10:55:07ZengGolestan University Of Medical SciencesJournal of Clinical and Basic Research2538-37362023-09-017257A clinico-immunohistopathological study of urothelial neoplasms with an expression of HER2/Neu and Ki-67 in malignant lesions presenting to a tertiary centreFatima Rasheed0Shilpa Karamchedu1Venkata Hari Charan Bagadi2Tabassum Misbah3Manisha Goud Punjala4Florence Nightingale5Karamchedu Suresh6 Department of Pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telangana-509001, India. Department of Pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telangana-509001, India. Department of Pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telangana-509001, India. Department of Pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telangana-509001, India. Department of Pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telangana-509001, India. Department of Pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telangana-509001, India. Department of Pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telangana-509001, India. Background: HER2/neu is associated with increased tumor grade, and Ki-67 is related to tumor recurrence and stage progression. This study aims to evaluate the clinical profile in patients with urothelial neoplasms and correlate the expression of HER2/neu and Ki-67 in urothelial carcinomas. Methods: This is a five-year retrospective study from June 2017 to May 2022 with forty cases from the Department of Pathology. A microscopic examination was done to assess the tumor stage and histological grade. Immunohistochemistry was performed with HER2/neu and Ki-67. Results: 65% (26/40) of the cases were diagnosed as infiltrating urothelial carcinoma, 30% (12) of the cases as low-grade non-invasive urothelial carcinoma, one case as a papillary urothelial neoplasm of low malignant potential (PUNLMP), and one case as urothelial papilloma. 95.5% of infiltrating carcinomas and 84.5% of low-grade non-invasive carcinomas were Ki-67-positive. A significant correlation was observed between the expression of Her-2/neu and Ki-67 and the 2016 World Health Organization (WHO) grading system of urothelial carcinoma. Moderate-to-strong HER2/neu overexpression (2+ or 3+) was observed in only 18% of cases. Conclusion: The expression of ki-67 increased with an increase in the grade of tumor, which shows its prognostic importance. The relation between Ki-67 expression and the histologic grade of the tumor and the presence of lymphovascular invasion was significant. A significant correlation was observed between the grade of the carcinoma and the immunohistochemical expression of HER2/neu, in which 19.3% of high-grade carcinoma cases showed immunohistochemical expression of the HER2/neu marker. Further studies with a larger population group are required to establish the role of HER2/neu as a prognostic marker.http://jcbr.goums.ac.ir/article-1-422-en.pdfher2/neuki- 67urothelial neoplasmsnon-muscle invasive bladder neoplasms |
| spellingShingle | Fatima Rasheed Shilpa Karamchedu Venkata Hari Charan Bagadi Tabassum Misbah Manisha Goud Punjala Florence Nightingale Karamchedu Suresh A clinico-immunohistopathological study of urothelial neoplasms with an expression of HER2/Neu and Ki-67 in malignant lesions presenting to a tertiary centre Journal of Clinical and Basic Research her2/neu ki- 67 urothelial neoplasms non-muscle invasive bladder neoplasms |
| title | A clinico-immunohistopathological study of urothelial neoplasms with an expression of HER2/Neu and Ki-67 in malignant lesions presenting to a tertiary centre |
| title_full | A clinico-immunohistopathological study of urothelial neoplasms with an expression of HER2/Neu and Ki-67 in malignant lesions presenting to a tertiary centre |
| title_fullStr | A clinico-immunohistopathological study of urothelial neoplasms with an expression of HER2/Neu and Ki-67 in malignant lesions presenting to a tertiary centre |
| title_full_unstemmed | A clinico-immunohistopathological study of urothelial neoplasms with an expression of HER2/Neu and Ki-67 in malignant lesions presenting to a tertiary centre |
| title_short | A clinico-immunohistopathological study of urothelial neoplasms with an expression of HER2/Neu and Ki-67 in malignant lesions presenting to a tertiary centre |
| title_sort | clinico immunohistopathological study of urothelial neoplasms with an expression of her2 neu and ki 67 in malignant lesions presenting to a tertiary centre |
| topic | her2/neu ki- 67 urothelial neoplasms non-muscle invasive bladder neoplasms |
| url | http://jcbr.goums.ac.ir/article-1-422-en.pdf |
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