Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27
BackgroundNerve compression disorders, such as carpal tunnel syndrome (CTS) and ulnar entrapment at the elbow (UNE), may be associated with apoptosis and neuroprotective mechanisms in the peripheral nerve that may be detected by biomarkers in the blood. The relationships between CTS and UNE and two...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.809537/full |
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| author | Elin Bergsten Elin Bergsten Mattias Rydberg Mattias Rydberg Lars B. Dahlin Lars B. Dahlin Lars B. Dahlin Malin Zimmerman Malin Zimmerman |
| author_facet | Elin Bergsten Elin Bergsten Mattias Rydberg Mattias Rydberg Lars B. Dahlin Lars B. Dahlin Lars B. Dahlin Malin Zimmerman Malin Zimmerman |
| author_sort | Elin Bergsten |
| collection | DOAJ |
| description | BackgroundNerve compression disorders, such as carpal tunnel syndrome (CTS) and ulnar entrapment at the elbow (UNE), may be associated with apoptosis and neuroprotective mechanisms in the peripheral nerve that may be detected by biomarkers in the blood. The relationships between CTS and UNE and two biomarkers of apoptosis, i.e., caspase-3 and caspase-8, and the neuroprotective factor Heat Shock Protein 27 (HSP27) in plasma were examined in a population-based cohort.MethodThe biomarkers caspase-3, caspase-8 and HSP27 were measured in plasma at inclusion of 4,284 study participants aged 46–68 years in the population-based Malmö Diet and Cancer study (MDCS). End-point retrieval was made from national registers concerning CTS and UNE. Independent t-test was used to examine the association between caspase-3, caspase-8 and HSP27 plasma levels and incidence of CTS and UNE. Cox proportional hazards regression was used to investigate if plasma levels of caspase-3, caspase-8 and HSP27 affected time to diagnosis of CTS or UNE.ResultsDuring the mean follow-up time of 22 years, 189/4,284 (4%) participants were diagnosed with CTS and 42/4,284 (1%) were diagnosed with UNE. No associations were found between incident CTS or UNE and the biomarkers caspase-3, caspase-8 and HSP27 in plasma.ConclusionThe apoptotic biomarkers caspase-3 and caspase-8 and the neuroprotective factor HSP27 in plasma, factors conceivably related to a nerve injury, are not associated with the nerve compression disorders CTS and UNE in a general population. |
| first_indexed | 2024-12-19T22:12:23Z |
| format | Article |
| id | doaj.art-1734c5f48d374eb9816d75e565b113ae |
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| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T22:12:23Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-1734c5f48d374eb9816d75e565b113ae2022-12-21T20:03:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-03-011610.3389/fnins.2022.809537809537Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27Elin Bergsten0Elin Bergsten1Mattias Rydberg2Mattias Rydberg3Lars B. Dahlin4Lars B. Dahlin5Lars B. Dahlin6Malin Zimmerman7Malin Zimmerman8Department of Orthopedics, Helsingborg Hospital, Helsingborg, SwedenDepartment of Translational Medicine—Hand Surgery, Lund University, Lund, SwedenDepartment of Translational Medicine—Hand Surgery, Lund University, Lund, SwedenDepartment of Hand Surgery, Skåne University Hospital, Malmö, SwedenDepartment of Translational Medicine—Hand Surgery, Lund University, Lund, SwedenDepartment of Hand Surgery, Skåne University Hospital, Malmö, SwedenDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenDepartment of Orthopedics, Helsingborg Hospital, Helsingborg, SwedenDepartment of Translational Medicine—Hand Surgery, Lund University, Lund, SwedenBackgroundNerve compression disorders, such as carpal tunnel syndrome (CTS) and ulnar entrapment at the elbow (UNE), may be associated with apoptosis and neuroprotective mechanisms in the peripheral nerve that may be detected by biomarkers in the blood. The relationships between CTS and UNE and two biomarkers of apoptosis, i.e., caspase-3 and caspase-8, and the neuroprotective factor Heat Shock Protein 27 (HSP27) in plasma were examined in a population-based cohort.MethodThe biomarkers caspase-3, caspase-8 and HSP27 were measured in plasma at inclusion of 4,284 study participants aged 46–68 years in the population-based Malmö Diet and Cancer study (MDCS). End-point retrieval was made from national registers concerning CTS and UNE. Independent t-test was used to examine the association between caspase-3, caspase-8 and HSP27 plasma levels and incidence of CTS and UNE. Cox proportional hazards regression was used to investigate if plasma levels of caspase-3, caspase-8 and HSP27 affected time to diagnosis of CTS or UNE.ResultsDuring the mean follow-up time of 22 years, 189/4,284 (4%) participants were diagnosed with CTS and 42/4,284 (1%) were diagnosed with UNE. No associations were found between incident CTS or UNE and the biomarkers caspase-3, caspase-8 and HSP27 in plasma.ConclusionThe apoptotic biomarkers caspase-3 and caspase-8 and the neuroprotective factor HSP27 in plasma, factors conceivably related to a nerve injury, are not associated with the nerve compression disorders CTS and UNE in a general population.https://www.frontiersin.org/articles/10.3389/fnins.2022.809537/fullcarpal tunnel syndromeulnar nerve compression syndromescaspase-3caspase-8HSP27heat-shock proteins |
| spellingShingle | Elin Bergsten Elin Bergsten Mattias Rydberg Mattias Rydberg Lars B. Dahlin Lars B. Dahlin Lars B. Dahlin Malin Zimmerman Malin Zimmerman Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27 Frontiers in Neuroscience carpal tunnel syndrome ulnar nerve compression syndromes caspase-3 caspase-8 HSP27 heat-shock proteins |
| title | Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27 |
| title_full | Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27 |
| title_fullStr | Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27 |
| title_full_unstemmed | Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27 |
| title_short | Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27 |
| title_sort | carpal tunnel syndrome and ulnar nerve entrapment at the elbow are not associated with plasma levels of caspase 3 caspase 8 or hsp27 |
| topic | carpal tunnel syndrome ulnar nerve compression syndromes caspase-3 caspase-8 HSP27 heat-shock proteins |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.809537/full |
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