Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011)
In the present work, a total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to the IDU-A genetic variant were analyzed. The variants were obtained from the viruses circulating among IDUs and heterosexuals in the Perm region at different periods. It was shown that the rate of the divergence of th...
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Central Research Institute for Epidemiology
2016-10-01
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| Series: | Вопросы вирусологии |
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| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/92/31 |
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| author | A. V. Lebedev E. V. Kazennova S. Ya. Zverev Yu. I. Nistratova V. Yu. Laga A. S. Tumanov N. V. Glushchenko E. I. Yarygina M. R. Bobkova |
| author_facet | A. V. Lebedev E. V. Kazennova S. Ya. Zverev Yu. I. Nistratova V. Yu. Laga A. S. Tumanov N. V. Glushchenko E. I. Yarygina M. R. Bobkova |
| author_sort | A. V. Lebedev |
| collection | DOAJ |
| description | In the present work, a total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to the IDU-A genetic variant were analyzed. The variants were obtained from the viruses circulating among IDUs and heterosexuals in the Perm region at different periods. It was shown that the rate of the divergence of the IDU-A HIV-1 viruses from a common ancestor increased 4.3 times (p < 0.001) in 2011 as compared with the onset of the epidemics. The rate of the HIV-1 evolution was different in the two risk groups of the infection. The mean genetic distance of HIV-1 variants circulating among heterosexuals was 1.3 times longer (p = 0.008) than that among IDUs. The accumulation rate of the nucleotide (including nonsynonymous) substitutions in the C2-V3-C3 HIV-1 env gene region among individuals infected by heterosexual contacts was 1.7 times higher than that among IDUs. The differences in the positions of the codons subjected to positive selection were demonstrated depending on the infection risk group tested. |
| first_indexed | 2024-03-13T00:07:27Z |
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| id | doaj.art-1734cdb6d4d24df1a82154af9b6265db |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:07:27Z |
| publishDate | 2016-10-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-1734cdb6d4d24df1a82154af9b6265db2023-07-12T20:03:31ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972016-10-0161522222910.18821/0507-4088-2016-61-5-222-22973Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011)A. V. Lebedev0E. V. Kazennova1S. Ya. Zverev2Yu. I. Nistratova3V. Yu. Laga4A. S. Tumanov5N. V. Glushchenko6E. I. Yarygina7M. R. Bobkova8«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»Perm Regional Center for Prevention and Control of AIDS and Infectious DiseasesPerm Regional Center for Prevention and Control of AIDS and Infectious Diseases«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»K.I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»In the present work, a total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to the IDU-A genetic variant were analyzed. The variants were obtained from the viruses circulating among IDUs and heterosexuals in the Perm region at different periods. It was shown that the rate of the divergence of the IDU-A HIV-1 viruses from a common ancestor increased 4.3 times (p < 0.001) in 2011 as compared with the onset of the epidemics. The rate of the HIV-1 evolution was different in the two risk groups of the infection. The mean genetic distance of HIV-1 variants circulating among heterosexuals was 1.3 times longer (p = 0.008) than that among IDUs. The accumulation rate of the nucleotide (including nonsynonymous) substitutions in the C2-V3-C3 HIV-1 env gene region among individuals infected by heterosexual contacts was 1.7 times higher than that among IDUs. The differences in the positions of the codons subjected to positive selection were demonstrated depending on the infection risk group tested.https://virusjour.crie.ru/jour/article/viewFile/92/31hiv-1idu-a variantgroup riskevolution |
| spellingShingle | A. V. Lebedev E. V. Kazennova S. Ya. Zverev Yu. I. Nistratova V. Yu. Laga A. S. Tumanov N. V. Glushchenko E. I. Yarygina M. R. Bobkova Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011) Вопросы вирусологии hiv-1 idu-a variant group risk evolution |
| title | Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011) |
| title_full | Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011) |
| title_fullStr | Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011) |
| title_full_unstemmed | Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011) |
| title_short | Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011) |
| title_sort | analysis of the env gene variability of the idu a hiv 1 variant in the outbreak of the hiv infection epidemic in perm region of russia 1996 2011 |
| topic | hiv-1 idu-a variant group risk evolution |
| url | https://virusjour.crie.ru/jour/article/viewFile/92/31 |
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