The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia
Background: Hyperuricemia has been associated with the development of high blood pressure (BP). We studied the effects of allopurinol therapy in hyperuricemic hemodialysis (HD) patients with high BP. Materials and Methods: This single-blind, randomized cross-over clinical study involved 55 HD patien...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=11;spage=1039;epage=1046;aulast=Jalalzadeh |
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| author | Mojgan Jalalzadeh Zeinalabedin Nurcheshmeh Ramin Mohammadi Nouraddin Mousavinasab Mohammad Hassan Ghadiani |
| author_facet | Mojgan Jalalzadeh Zeinalabedin Nurcheshmeh Ramin Mohammadi Nouraddin Mousavinasab Mohammad Hassan Ghadiani |
| author_sort | Mojgan Jalalzadeh |
| collection | DOAJ |
| description | Background: Hyperuricemia has been associated with the development of high blood pressure (BP). We studied the effects of allopurinol therapy in hyperuricemic hemodialysis (HD) patients with high BP. Materials and Methods: This single-blind, randomized cross-over clinical study involved 55 HD patients with serum uric acid level > 6.5 (men) and > 5.5 mg/dL (women). They were randomly divided in two groups, each of which went through two phases. Group-1 in phase-1 received 100 mg/day orally of allopurinol for three months; while Group-2 was given whatever medication they received prior to the study. After two months of washing period, the groups were crossed-over. The BP levels were measured before and after HD during the eight months study period. Results: Fifty-three patients completed the study (33 men and 20 women, with mean age of 55.8 years). Uric acid levels decreased significantly during the12 weeks of allopurinol therapy (7.71 ± 1.53 to 5.2 ± 1.2 P < 0.005). Overall, after the 12 weeks of allopurinol therapy, systolic and diastolic BP also significantly decreased in allopurinol group, 15.8% (139 to 117, P < 0.0005) and 8.6% (81 to 74, P < .0005), respectively. There were not significant changes in body mass index, blood urea nitrogen, creatinine, albumin, cholesterol, triglyceride, hemoglobin, liver enzymes and serum electrolytes level after treatment. Patients treated with allopurinol had a significant increase in the quality of dialysis (KT/V) (P: 0.043). Conclusions: In HD patients, allopurinol treatment reduced BP. The results indicate a new potential therapeutic approach for controlling BP in HD patients. |
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| format | Article |
| id | doaj.art-1735693273164673958ef76ce6bee3f1 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-13T07:28:49Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-1735693273164673958ef76ce6bee3f12022-12-22T02:56:24ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362012-01-01171110391046The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemiaMojgan JalalzadehZeinalabedin NurcheshmehRamin MohammadiNouraddin MousavinasabMohammad Hassan GhadianiBackground: Hyperuricemia has been associated with the development of high blood pressure (BP). We studied the effects of allopurinol therapy in hyperuricemic hemodialysis (HD) patients with high BP. Materials and Methods: This single-blind, randomized cross-over clinical study involved 55 HD patients with serum uric acid level > 6.5 (men) and > 5.5 mg/dL (women). They were randomly divided in two groups, each of which went through two phases. Group-1 in phase-1 received 100 mg/day orally of allopurinol for three months; while Group-2 was given whatever medication they received prior to the study. After two months of washing period, the groups were crossed-over. The BP levels were measured before and after HD during the eight months study period. Results: Fifty-three patients completed the study (33 men and 20 women, with mean age of 55.8 years). Uric acid levels decreased significantly during the12 weeks of allopurinol therapy (7.71 ± 1.53 to 5.2 ± 1.2 P < 0.005). Overall, after the 12 weeks of allopurinol therapy, systolic and diastolic BP also significantly decreased in allopurinol group, 15.8% (139 to 117, P < 0.0005) and 8.6% (81 to 74, P < .0005), respectively. There were not significant changes in body mass index, blood urea nitrogen, creatinine, albumin, cholesterol, triglyceride, hemoglobin, liver enzymes and serum electrolytes level after treatment. Patients treated with allopurinol had a significant increase in the quality of dialysis (KT/V) (P: 0.043). Conclusions: In HD patients, allopurinol treatment reduced BP. The results indicate a new potential therapeutic approach for controlling BP in HD patients.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=11;spage=1039;epage=1046;aulast=JalalzadehAllopurinolend stage renal diseasehigh blood pressureuric acid |
| spellingShingle | Mojgan Jalalzadeh Zeinalabedin Nurcheshmeh Ramin Mohammadi Nouraddin Mousavinasab Mohammad Hassan Ghadiani The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia Journal of Research in Medical Sciences Allopurinol end stage renal disease high blood pressure uric acid |
| title | The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia |
| title_full | The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia |
| title_fullStr | The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia |
| title_full_unstemmed | The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia |
| title_short | The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia |
| title_sort | effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia |
| topic | Allopurinol end stage renal disease high blood pressure uric acid |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=11;spage=1039;epage=1046;aulast=Jalalzadeh |
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