Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis
Abstract Background Syphilis remained a major cause of reproductive morbidity and poor pregnancy outcomes in developing countries. Previously, studies showed inconsistent results and failed to show the actual picture of the diseases in Ethiopia. Thus, the aim of this meta-analysis was, first, to det...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Systematic Reviews |
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| Online Access: | https://doi.org/10.1186/s13643-021-01786-3 |
| _version_ | 1818600063178375168 |
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| author | Habtamu Geremew Demeke Geremew |
| author_facet | Habtamu Geremew Demeke Geremew |
| author_sort | Habtamu Geremew |
| collection | DOAJ |
| description | Abstract Background Syphilis remained a major cause of reproductive morbidity and poor pregnancy outcomes in developing countries. Previously, studies showed inconsistent results and failed to show the actual picture of the diseases in Ethiopia. Thus, the aim of this meta-analysis was, first, to determine the updated pooled prevalence of syphilis among pregnant women in Ethiopia and, second, to assess its associated factors. Methods A comprehensive search was made on PubMed, Google scholar, Science Direct, and African Journals Online databases to identify relevant articles. A random effects model was used to estimate pooled syphilis prevalence and odds ratio (OR) with the respective 95% confidence intervals (CIs) using STATA 14 statistical software. I 2 statistics and Egger’s regression test in conjunction with funnel plot was used to determine heterogeneity and publication bias among included studies respectively. Result We identified 13 suitable studies in this analysis. Accordingly, the pooled prevalence of syphilis among pregnant women in Ethiopia was 2.32% (95% CI, 1.68–2.97). Specifically, syphilis prevalence was 2.53% (95% CI, 1.92–3.14%) and 1.90% (95% CI, 0.40–3.40%) as per the treponemal and non-ytreponemal diagnostic test, respectively. On the other hand, regional analysis indicated that 4.06% (95% CI, 2.86–5.26) in Southern Nations Nationalities and Peoples (SNNP), 2.16% (95% CI, 1.57–2.75) in Amhara and 1.46% (95% CI, 0.69–2.23) in Oromia region. Being married (OR, 0.37 (95% CI, 0.12–0.91%)) was less likely to develop syphilis. On the other hand, women with history of multiple sexual partner (OR, 2.98 (95% CI, 1.15–7.70)) and women with history of previous sexually transmitted infection (STI) (OR, 4.88 (95% CI, 1.35–17.62)) have higher risk to develop syphilis. Besides, the pooled syphilis-HIV coinfection was 0.80% (95% CI, 0.60–1.01%). Conclusion This study provides evidence of relatively high prevalence of syphilis among pregnant women in Ethiopia. Therefore, it is recommended to further ramping up of current intervention measures to prevent future generations. Systematic review registration PROSPERO CRD42020211650 |
| first_indexed | 2024-12-16T12:29:32Z |
| format | Article |
| id | doaj.art-1735a6f63e5d4b06a609cc05f4f37699 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-12-16T12:29:32Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-1735a6f63e5d4b06a609cc05f4f376992022-12-21T22:31:43ZengBMCSystematic Reviews2046-40532021-08-011011910.1186/s13643-021-01786-3Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysisHabtamu Geremew0Demeke Geremew1Department of Public Health, College of Health Sciences, Debre Markos UniversityDepartment of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, University of GondarAbstract Background Syphilis remained a major cause of reproductive morbidity and poor pregnancy outcomes in developing countries. Previously, studies showed inconsistent results and failed to show the actual picture of the diseases in Ethiopia. Thus, the aim of this meta-analysis was, first, to determine the updated pooled prevalence of syphilis among pregnant women in Ethiopia and, second, to assess its associated factors. Methods A comprehensive search was made on PubMed, Google scholar, Science Direct, and African Journals Online databases to identify relevant articles. A random effects model was used to estimate pooled syphilis prevalence and odds ratio (OR) with the respective 95% confidence intervals (CIs) using STATA 14 statistical software. I 2 statistics and Egger’s regression test in conjunction with funnel plot was used to determine heterogeneity and publication bias among included studies respectively. Result We identified 13 suitable studies in this analysis. Accordingly, the pooled prevalence of syphilis among pregnant women in Ethiopia was 2.32% (95% CI, 1.68–2.97). Specifically, syphilis prevalence was 2.53% (95% CI, 1.92–3.14%) and 1.90% (95% CI, 0.40–3.40%) as per the treponemal and non-ytreponemal diagnostic test, respectively. On the other hand, regional analysis indicated that 4.06% (95% CI, 2.86–5.26) in Southern Nations Nationalities and Peoples (SNNP), 2.16% (95% CI, 1.57–2.75) in Amhara and 1.46% (95% CI, 0.69–2.23) in Oromia region. Being married (OR, 0.37 (95% CI, 0.12–0.91%)) was less likely to develop syphilis. On the other hand, women with history of multiple sexual partner (OR, 2.98 (95% CI, 1.15–7.70)) and women with history of previous sexually transmitted infection (STI) (OR, 4.88 (95% CI, 1.35–17.62)) have higher risk to develop syphilis. Besides, the pooled syphilis-HIV coinfection was 0.80% (95% CI, 0.60–1.01%). Conclusion This study provides evidence of relatively high prevalence of syphilis among pregnant women in Ethiopia. Therefore, it is recommended to further ramping up of current intervention measures to prevent future generations. Systematic review registration PROSPERO CRD42020211650https://doi.org/10.1186/s13643-021-01786-3SyphilisAero-prevalencePregnant womenMeta-analysisEthiopia |
| spellingShingle | Habtamu Geremew Demeke Geremew Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis Systematic Reviews Syphilis Aero-prevalence Pregnant women Meta-analysis Ethiopia |
| title | Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis |
| title_full | Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis |
| title_fullStr | Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis |
| title_full_unstemmed | Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis |
| title_short | Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis |
| title_sort | sero prevalence of syphilis and associated factors among pregnant women in ethiopia a systematic review and meta analysis |
| topic | Syphilis Aero-prevalence Pregnant women Meta-analysis Ethiopia |
| url | https://doi.org/10.1186/s13643-021-01786-3 |
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